Writing Apprehension and Academic Achievement Among Undergraduate Honors Students

College students face many challenges upon their arrival to campus. One growing concern is the writing level of students, praticularly when issues of technologically-mediated writing are considered. This study examines writing apprehension among honors students at one university. Results indicated that moderate levels of writing apprehension do exist among these honors students, and that some relationship between fear of writing and poor academic performance does exist

Transmission Imaging With Axially Overlapping Cone-Beams

We have shown that cone-beam transmission imaging of medium-energy photons that penetrate the parallel-hole collimators can be used to rapidly estimate attenuation maps for use in reconstruction of cardiac SPECT images. Such a transmission imaging geometry offers the advantages of eliminating the need to mechanically move the point-sources during imaging, and minimizes cross-talk between emission and transmission imaging. The axial extent over which artifact-free attenuation maps can be reconstructed is limited by the cone-beam geometry and source collimation. We investigated irradiation of a single head by multiple point-sources such that their asymmetric cone-beam fields overlap in the axial direction as a method of extending the axial coverage of the patient. This study reports on testing of a penalized-likelihood algorithm for transmission reconstruction of overlapping cone-beams. This algorithm was evaluated through MCAT simulations and applied to transmission measurements of an anthropomorphic phantom. The experimental work consisted of performing a series of flood and transmission measurements on the anthropomorphic phantom with shifted axial locations of point-sources. We summed the projection data from individual measurements to simulate the projection data for a multiple point-source system. With the proposed penalized-Iikelihood algorithm, the full axial extent (20.5 cm) of the anthropomorphic phantom was reconstructed for the overlapping cone-beam geometry with 2 point-sources per camera head.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/85904/1/Fessler202.pd

Microstructure Formation and Resistivity Change in CuCr during Rapid Solidification

The formation of the surface-near microstructure after a current interruption of CuCr contact materials in a vacuum interrupter is characterized by a fast heating and subsequently rapid solidification process. In the present article, we reveal and analyse the formation of two distinct microstructural regions that result from the heat, which is generated and dissipated during interruption. In the topmost region, local and global texture, as well as the resulting microstructure, indicate that both Cu and Cr were melted during rapid heating and solidification whereas in the region underneath, only Cu was melted and elongated Cu-grains solidified with the <001>-direction perpendicularly aligned to the surface. By analysing the lattice parameter of the Cu solid solution, a supersaturation of the solid solution with about 2.25 at % Cr was found independent if Cu was melted solely or together with the Cr. The according reduction of electrical conductivity in the topmost region subsequent to current interruption and the resulting heat distribution are discussed based on these experimental results

Microstructure Formation and Resistivity Change in CuCr during Rapid Solidification

The formation of the surface-near microstructure after a current interruption of CuCr contact materials in a vacuum interrupter is characterized by a fast heating and subsequently rapid solidification process. In the present article, we reveal and analyse the formation of two distinct microstructural regions that result from the heat, which is generated and dissipated during interruption. In the topmost region, local and global texture, as well as the resulting microstructure, indicate that both Cu and Cr were melted during rapid heating and solidification whereas in the region underneath, only Cu was melted and elongated Cu-grains solidified with the -direction perpendicularly aligned to the surface. By analysing the lattice parameter of the Cu solid solution, a supersaturation of the solid solution with about 2.25 at % Cr was found independent if Cu was melted solely or together with the Cr. The according reduction of electrical conductivity in the topmost region subsequent to current interruption and the resulting heat distribution are discussed based on these experimental results

Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging

Objective: In preclinical research, the use of [F-18]Fluorodesoxyglucose (FDG) as a biomarker for neuro-degeneration may induce bias due to enhanced glucose uptake by immune cells. In this study, we sought to investigate synaptic vesicle glycoprotein 2A (SV2A) PET with [F-18]UCB-H as an alternative preclinical biomarker for neurodegenerative processes in two mouse models representing the pathological hallmarks of Alzheimer's disease (AD). Methods: A total of 29 PS2APP, 20 P301S and 12 wild-type mice aged 4.4 to 19.8 months received a dynamic [F-18]UCB-H SV2A-PET scan (14.7 +/- 1.5 MBq) 0-60 min post injection. Quantification of tracer uptake in cortical, cerebellar and brainstem target regions was implemented by calculating relative volumes of distribution (V-T) from an image-derived-input-function (IDIF). [F-18]UCB-H binding was compared across all target regions between transgenic and wild-type mice. Additional static scans were performed in a subset of mice to compare [F-18]FDG and [F-18]GE180 (18 kDa translocator protein tracer as a surrogate for microglial activation) standardized uptake values (SUV) with [F-18]UCB-H binding at different ages. Following the final scan, a subset of mouse brains was immunohistochemically stained with synaptic markers for gold standard validation of the PET results. Results: [F-18]UCB-H binding in all target regions was significantly reduced in 8-months old P301S transgenic mice when compared to wild-type controls (temporal lobe: p = 0.014;cerebellum: p = 0.0018;brainstem: p = 0.0014). Significantly lower SV2A tracer uptake was also observed in 13-months (temporal lobe: p = 0.0080;cerebellum: p = 0.006) and 19-months old (temporal lobe: p = 0.0042;cerebellum: p = 0.011) PS2APP transgenic versus wild-type mice, whereas the brainstem revealed no significantly altered [F-18]UCB-H binding. Immunohistochemical analyses of post-mortem mouse brain tissue confirmed the SV2A PET findings. Correlational analyses of [F-18]UCB-H and [F-18]FDG using Pearson's correlation coefficient revealed a significant negative association in the PS2APP mouse model (R = -0.26, p = 0.018). Exploratory analyses further stressed microglial activation as a potential reason for this inverse relationship, since [F-18]FDG and [F-18]GE180 quantification were positively correlated in this cohort (R = 0.36, p = 0.0076). Conclusion: [F-18]UCB-H reliably depicts progressive synaptic loss in PS2APP and P301S transgenic mice, potentially qualifying as a more reliable alternative to [F-18]FDG as a biomarker for assessment of neuro-degeneration in preclinical research

A practical indicator for surface ocean heat and freshwater buoyancy fluxes and its application to the NCEP reanalysis data

The buoyancy flux at the air/sea interface plays a key role in water mass transformation and mixing as it modifies surface water density and in turn drives overturning and enhances stratification. It is the interplay of these two independent heat and freshwater buoyancy flux components that is of central importance when analysing mechanisms of the ocean/atmosphere interaction. Here, a diagnostic quantity (ΘB) is presented that allows to capture the relative contribution of both components on the buoyancy flux in one single quantity. Using NCEP reanalysis of heat and freshwater fluxes (1948–2009) demonstrates that ΘB is a convenient tool to analyse both the temporal and spatial variability of their corresponding buoyancy fluxes. For the global ocean the areal extent of buoyancy gain and loss regions changed by 10%, with the largest extent of buoyancy gain during the 1970–1990 period. In the subpolar North Atlantic, and likewise in the South Pacific, decadal variability in freshwater flux is pronounced and, for the latter region, takes control over the total buoyancy flux since the 1980s. Some of the areal extent time series show a significant correlation with large-scale climate indices

Exploration of Antarctic Ice Sheet 100-year contribution to sea level rise and associated model uncertainties using the ISSM framework

Estimating the future evolution of the Antarctic Ice Sheet (AIS) is critical for improving future sea level rise (SLR) projections. Numerical ice sheet models are invaluable tools for bounding Antarctic vulnerability; yet, few continental-scale projections of century-scale AIS SLR contribution exist, and those that do vary by up to an order of magnitude. This is partly because model projections of future sea level are inherently uncertain and depend largely on the model's boundary conditions and climate forcing, which themselves are unknown due to the uncertainty in the projections of future anthropogenic emissions and subsequent climate response. Here, we aim to improve the understanding of how uncertainties in model forcing and boundary conditions affect ice sheet model simulations. With use of sampling techniques embedded within the Ice Sheet System Model (ISSM) framework, we assess how uncertainties in snow accumulation, ocean-induced melting, ice viscosity, basal friction, bedrock elevation, and the presence of ice shelves impact continental-scale 100-year model simulations of AIS future sea level contribution. Overall, we find that AIS sea level contribution is strongly affected by grounding line retreat, which is driven by the magnitude of ice shelf basal melt rates and by variations in bedrock topography. In addition, we find that over 1.2&thinsp;m of AIS global mean sea level contribution over the next century is achievable, but not likely, as it is tenable only in response to unrealistically large melt rates and continental ice shelf collapse. Regionally, we find that under our most extreme 100-year warming experiment generalized for the entire ice sheet, the Amundsen Sea sector is the most significant source of model uncertainty (1032&thinsp;mm 6σ spread) and the region with the largest potential for future sea level contribution (297&thinsp;mm). In contrast, under a more plausible forcing informed regionally by literature and model sensitivity studies, the Ronne basin has a greater potential for local increases in ice shelf basal melt rates. As a result, under this more likely realization, where warm waters reach the continental shelf under the Ronne ice shelf, it is the Ronne basin, particularly the Evans and Rutford ice streams, that are the greatest contributors to potential SLR (161&thinsp;mm) and to simulation uncertainty (420&thinsp;mm 6σ spread).</p

Impact of the solar cycle and the QBO on the atmosphere and the ocean

The Solar Cycle and the Quasi-Biennial Oscillation are two major components of natural climate variability. Their direct and indirect influences in the stratosphere and troposphere are subject of a number of studies. The so-called ``top-down' mechanism describes how solar UV changes can lead to a significant enhancement of the small initial signal and corresponding changes in stratospheric dynamics. How the signal then propagates to the surface is still under investigation. We continue the ``top-down' analysis further down to the ocean and show the dynamical ocean response with respect to the solar cycle and the QBO. For this we use two 110-year chemistry climate model experiments from NCAR's Whole Atmosphere Community Climate Model (WACCM), one with a time varying solar cycle only and one with an additionally nudged QBO, to force an ocean general circulation model, GFZ's Ocean Model for Circulation and Tides (OMCT). We find a significant ocean response to the solar cycle only in combination with a prescribed QBO. Especially in the Southern Hemisphere we find the tendency to positive Southern Annular Mode (SAM) like pattern in the surface pressure and associated wind anomalies during solar maximum conditions. These atmospheric anomalies propagate into the ocean and induce deviations in ocean currents down into deeper layers, inducing an integrated sea surface height signal. Finally, limitations of this study are discussed and it is concluded that comprehensive climate model studies require a middle atmosphere as well as a coupled ocean to investigate and understand natural climate variability. Key Points: - Modeled oceanic solar cycle response depends on realistically modeled stratosphe - A realistically modeled stratospheric solar cycle response requires a QB