P-equilibrium fertilization in an intensive dairy farming system: effects on soil-P status, crop yield and P leaching

In the coming decade, European dairy farms are obliged to realize a balance between phosphor (P) inputs to their farmland (in inorganic fertilizers and manure) and outputs (in crop products), the so-called P-equilibrium fertilization. The objective of the present study is to analyze the long-term effects of P-equilibrium fertilization on soil-P status (total soil-P and available soil-P), crop yield and P leaching on dry sandy soil, using data from experimental dairy farm ‘De Marke’, where P-equilibrium fertilization has been applied since 1989. For grassland, P availability is expressed in P-Al and for arable land in Pw. Total and available P status were monitored in the upper topsoil (layer 0–0.2 m). Total soil-P was also monitored in the lower topsoil (layer 0.2–0.4 m) and in the subsoil (0.4–0.6 m). From 1989 to 2006, Pw and P-Al (means of all farmland) decreased by 26 and 25%, respectively. In the same period, mean total-P content of the farmland decreased by 16%. There was a large variation in initial P status (1989) of the various plots. The rate of decline in all soil-P indicators was positively correlated to their initial values. In plots with the lowest initial values, P status did not change, while in plots with high initial values it tended to stabilize at lower levels. At equilibrium-P fertilization, Pw is estimated to stabilize at 20. This is lower than the recommended P status of Dutch soils used for maize cropping. P-Al is estimated to stabilize at 30–40, which corresponds to the current recommendations for grassland. The data show that at P-equilibrium fertilization, soil available-P status is higher in a maize-ley rotation than in permanent grassland. The decline in total P and available P did not affect crop yield, nor did it affect the P concentration in groundwater, but at ‘De Marke’, P emission to groundwater is generally low. The results obtained suggest that P-equilibrium fertilization can be compatible with efficient crop productio

Kunstmestvervangers onderzocht; Eerste ervaringen met mineralenconcentraat op 'Telen met Toekomst-bedrijf'Van den Berg gunstig

Onderzoek naar praktijkervaringen met kunstmestvervangers. In dit informatieblad staan de ervaringen op "Telen met Toekomst-bedrijf" Van den Berg centraal

Study protocol to investigate the effect of a lifestyle intervention on body weight, psychological health status and risk factors associated with disease recurrence in women recovering from breast cancer treatment

Background Breast cancer survivors often encounter physiological and psychological problems related to their diagnosis and treatment that can influence long-term prognosis. The aim of this research is to investigate the effects of a lifestyle intervention on body weight and psychological well-being in women recovering from breast cancer treatment, and to determine the relationship between changes in these variables and biomarkers associated with disease recurrence and survival. Methods/design Following ethical approval, a total of 100 patients will be randomly assigned to a lifestyle intervention (incorporating dietary energy restriction in conjunction with aerobic exercise training) or normal care control group. Patients randomised to the dietary and exercise intervention will be given individualised healthy eating dietary advice and written information and attend moderate intensity aerobic exercise sessions on three to five days per week for a period of 24 weeks. The aim of this strategy is to induce a steady weight loss of up to 0.5 Kg each week. In addition, the overall quality of the diet will be examined with a view to (i) reducing the dietary intake of fat to ~25% of the total calories, (ii) eating at least 5 portions of fruit and vegetables a day, (iii) increasing the intake of fibre and reducing refined carbohydrates, and (iv) taking moderate amounts of alcohol. Outcome measures will include body weight and body composition, psychological health status (stress and depression), cardiorespiratory fitness and quality of life. In addition, biomarkers associated with disease recurrence, including stress hormones, estrogen status, inflammatory markers and indices of innate and adaptive immune function will be monitored. Discussion This research will provide valuable information on the effectiveness of a practical, easily implemented lifestyle intervention for evoking positive effects on body weight and psychological well-being, two important factors that can influence long-term prognosis in breast cancer survivors. However, the added value of the study is that it will also evaluate the effects of the lifestyle intervention on a range of biomarkers associated with disease recurrence and survival. Considered together, the results should improve our understanding of the potential role that lifestyle-modifiable factors could play in saving or prolonging lives

Do teachers need instructional analogies to teach mother-tongue (L1)? – Teachers’ perceptions and representations of difficult topics in mother-tongue education. L1

Wetensch. publicatieICLO

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Forming a collaborative action research partnership

This article describes the complex nature of collaborative relationships, the difficulties of conducting research with others, and the complications of partnerships in educational research. To create and sustain a communicative space in which participants can collaborate to innovate education and curriculum, time and opportunity to develop trust in the group are needed. We report on a collaborative action research project in the Netherlands in which 14 teachers, three facilitators and an academic researcher formed a partnership, and together designed Language 1 education. We find contextual and the communicative conditions are important in the collaborative action research partnership. We use metaphors of facilitative actions – map, magnifying glass, mirror and compass – formulated by Wadsworth to analyze and describe the collaboration. We show that the participants had to come to terms with their roles and responsibilities and, through dialogue and reflection, evolved and learned to contribute to the collaborative action research partnership by sustaining dialogue and utilizing their unique expertise. Keywords: collaborative action research partnership; communicative space; contextual conditions; communicative conditions; communicative actions; Language 1 education; metaphorsTeaching and Teacher Learning (ICLON

Evaluatie wet bijzondere politieregisters

De Wet Bijzondere Politieregisters vloeit voort uit het onderzoek van de parlementaire enquêtecommissie opsporingsmethoden (commissie Van-Traa). De wet regelt welke gegevens er in de ‘bijzondere registers’ van de politie opgenomen mogen worden, aan wie zij verstrekt mogen worden (binnen de politie en aan derden) en de bewaartermijn. In dit onderzoek wordt nagegaan wat, in de praktijk, de gevolgen zijn van de Wet Bijzondere Politieregisters, welke knelpunten zich daarbij openbaren en wat de doeltreffendheid is van deze wet

Teacher agency within the context of formative teacher assessment:An in-depth analysis

Teachers' agency has an effect on their own learning process at the workplace. In this study we explored the extent to which teachers participating in a formative teacher assessment procedure developed a sense of agency. We investigated not only whether teachers participating in a such an assessment procedure experienced agency and thus felt in control of the learning process and able to pursue their learning objectives, but also whether agency was visible, by looking at decision-making in real time: did teachers take an active role in their own assessment, especially regarding the learning objectives to be pursued, during the assessment meetings? We found that teachers experienced a high level of agency while participating in the assessment procedure, but did not consistently show this during the assessment procedure

Cancer risk in DES daughters

We examined long-term risk of cancer in women exposed to diethylstilbestrol (DES) in utero. A total of 12,091 DES-exposed women in the Netherlands were followed prospectively from December 1992 till June 2008. Cancer incidence was assessed through linkage with the Dutch pathology database (PALGA) and the Netherlands Cancer Registry and compared with the Dutch female population. A total of 348 medically verified cancers occurred; median age at end of follow-up was 44.0 years. No overall increased risk of cancer was found (standardized incidence ratio [SIR] = 1.01; 95% confidence interval [CI] = 0.91, 1.13). The risk of clear cell adenocarcinoma of the vagina and cervix (CCA) was statistically significantly increased (SIR = 24.23; 95% CI = 8.89, 52.74); the elevated risk persisted above 40 years of age. The risk of melanoma diagnosed before age 40 was increased (SIR = 1.59; 95% CI = 1.08, 2.26). No excess risks were found for other sites, including breast cancer. Except for an elevated risk of CCA, persisting at older ages, and an increased risk of melanoma at young ages, we found no increased risk of cancer. Longer follow-up is warranted to examine cancer risk at ages when cancer occurs more frequently