Study of free surface flows in rectangular channel over rough beds.

This paper presents the results of an experimental and umerical study of fully developed flow in a straight rectangular open channel over rough beds. Conical ribs were placed on the flume bottom to simulate different bed roughness conditions. Acoustic Doppler Velocimetry (ADV) measurements were made to obtain the velocity components profiles as well as the Reynolds stress profiles, at various locations. The experimental results are validated by simulations using an algebraic stress model. These investigations could be useful for researches in the field of sediment transport, bank protection, etc

Flow over Flexible Vegetated Bed: Evaluation of Analytical Models

The development of vegetation in the river bed and in the banks can affect the hydrodynamic conditions and the flow behavior of a watercourse. This can increase the risk of flooding and sediment transport. Therefore, it is important to develop analytical approaches to predict the resistance caused by vegetation and model its effect on the flow. This is the objective of this work which investigates the ability of different analytical models to predict the vertical velocity profile as well as the resistance induced by flexible submerged vegetation in open channels. Then it is possible to select the appropriate model that will be applied in the real case of rivers. The model validation is determined after a comparison between the data measured in the different experiments carried out and those from literature. For dense vegetation, the role of the Reynolds number is emphasized in particular with a model using the Darcy-Brinkman equation in the canopy. With a simple permeability, this model is relevant to estimate friction. However, for larger Reynolds number, models based on the fully turbulent flow assumption provide better results

Study of Free Surface Flows in Rectangular Channel over Rough Beds

This paper presents the results of an experimental and numerical study of fully developed flow in a straight rectangular open channel over rough beds. Conical ribs were placed on the flume bottom to simulate different bed roughness conditions. Acoustic Doppler Velocimetry (ADV) measurements were made to obtain the velocity components profiles as well as the Reynolds stress profiles, at various locations. The experimental results are validated by simulations using an algebraic stress model. These investigations could be useful for researches in the field of sediment transport, bank protection, etc

Quantitative structure anti-proliferative activity against HEPG2 and SW1116 relationships in a series of Pyrazine Derivatives

International audienceQuantitative structure activity relationship (QSAR) methods have been applied in several scientific studies including chemistry, biology and toxicology and drug discovery to predict and classify biological activities of virtual or newly-synthesized compounds. QSAR models can also be used in designing new chemical entities and are now regarded as essential tools in pharmaceutical industries to identify promising hits and generate high quality leads in the early stages of drug discovery. QSAR studies were performed on a series of pyrazine as anti-proliferative agents. A multiple linear regression (MLR) procedure was used to envisage the relationships between molecular descriptors and the activity of pyrazine derivatives. The predictivity of the model was estimated by cross-validation with the leave-one-out method. Our results suggest a QSAR model based of the following descriptors: logP, HE, SAG, Pol, qC3 for the anti-proliferative activity against the HEPG2 (human liver cancer cell) and logP, HE, MR, SAG, Vol, qC2, qC5, qC6, LUMO for the anti-proliferative activity against the SW1116 (human colorectal carcinoma cell). To confirm the predictive power of the models, an external set of molecules was used. High correlation between experimental and predicted activity values was observed, indicating the validation and the good quality of the derived QSAR models. Copyright © 2017 American Scientific Publishers All rights reserved

Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis

Kallikrein-related peptidases (KLKs) are implicated in many cancer-related processes. KLK6, one of the 15 KLK family members, is a promising biomarker for diagnosis of many cancers and has been associated with poor prognosis of colorectal cancer (CRC) patients. Herein, we evaluated the expression and cellular functions of KLK6 in colon cancer-derived cell lines and in clinical samples from CRC patients. We showed that, although many KLKs transcripts are upregulated in colon cancer-derived cell lines, KLK6, KLK10, and KLK11 are the most highly secreted proteins. KLK6 induced calcium flux in HT29 cells by activation and internalization of protease-activated receptor 2 (PAR2). Furthermore, KLK6 induced extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. KLK6 suppression in HCT-116 colon cancer cells decreased the colony formation, increased cell adhesion to extracellular matrix proteins, and reduced spheroid formation and compaction. Immunohistochemistry (IHC) analysis demonstrated ectopic expression of KLK6 in human colon adenocarcinomas but not in normal epithelia. Importantly, high levels of KLK6 protein were detected in the ascites of CRC patients with peritoneal metastasis, but not in benign ascites. These data indicate that KLK6 overexpression is associated with aggressive CRC, and may be applied to differentiate between benign and malignant ascites.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

On Contributing to the Progress of Medical Informatics as Publisher

May 1st, 2017, will mark Dieter Bergemann's 80th birthday. As Chief Executive Officer and Owner of Schattauer Publishers from 1983 to 2016, the biomedical and health informatics community owes him a great debt of gratitude. The past and present editors of Methods of Information in Medicine, the IMIA Yearbook of Medical Informatics, and Applied Clinical Informatics want to honour and thank Dieter Bergemann by providing a brief biography that emphasizes his contributions, by reviewing his critical role as an exceptionally supportive publisher for Schattauer's three biomedical and health informatics periodicals, and by sharing some personal anecdotes. Over the past 40 years, Dieter Bergemann has been an influential, if behind-the-scenes, driving force in biomedical and health informatics publications, helping to ensure success in the dissemination of our field's research and practice