266 research outputs found
Drift chamber with a c-shaped frame
We present the construction of a planar drift chamber with wires stretched
between two arms of a c-shaped aluminium frame. The special shape of the frame
allows to extendthe momentum acceptance of the COSY-11 detection system towards
lower momenta without suppressing the high momentum particles. The proposed
design allows for construction of tracking detectors covering small angles with
respect to the beam, which can be installed and removed without dismounting the
beam-pipe. For a three-dimensional track reconstruction a computer code was
developed using a simple algorithm of hit preselection.Comment: submitted to Nucl. Instr. & Meth
Features of financing of small business and microenterprises
In this article, we examined the specifics of financing small businesses and microenterprises
Dasatinib preferentially induces apoptosis by inhibiting Lyn kinase in nilotinib-resistant chronic myeloid leukemia cell line
Nilotinib is approved for treatment of newly diagnosed chronic myeloid leukemia (CML) and it is shown superiority over imatinib in first-line treatment for patients of CML. In this study, we established a nilotinib-resistant cell line, K562NR, and evaluated the resistance to nilotinib and efficacy of dasatinib. We found activation of Lyn plays a dominant role in survival of the nilotinib-resistant cell line. We found dasatinib induces the apoptosis of nilotinib-resistant cells and inhibits Lyn kinase activity. This novel nilotinib-resistant CML cell line may help to explore novel therapy for CML
Heavy Meson Production at COSY - 11
The COSY-11 collaboration has measured the total cross section for the pp -->
pp eta-prime and pp --> pp eta reactions in the excess energy range from
Q = 1.5 MeV to Q = 23.6 MeV and from Q = 0.5 MeV to Q = 5.4 MeV,
respectively.
Measurements have been performed with the total luminosity of 73 nb^(-1) for
the pp --> pp eta reaction and 1360 nb^(-1) for the pp --> pp eta-prime one.
Recent results are presented and discussed.Comment: Invited talk at 4th International Conference on Physics at Storage
Rings (STORI 99), Bloomington, Indiana, USA, September 12-16, 199
Monitoring of the accelerator beam distributions for internal target facilities
We describe a direct method for monitoring the geometrical dimensions of a
synchrotron beam at the target position for internal target installations. The
method allows for the observation of the proton beam size as well as the
position of the beam relative to the target. As a first demonstration of the
technique, we present results obtained by means of the COSY-11 detection system
installed at the cooler synchrotron COSY. The influence of the stochastic
cooling on the COSY proton beam dimensions is also investigated.Comment: 7 pages, 8 figures, Submitted to Nucl. Inst. & Meth.
SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines
<p>Abstract</p> <p>Background</p> <p><it>SET-NUP214 </it>fusion resulting from a recurrent cryptic deletion, del(9)(q34.11q34.13) has recently been described in T-cell acute lymphoblastic leukemia (T-ALL) and in one case of acute myeloid leukemia (AML). The fusion protein appears to promote elevated expression of <it>HOXA </it>cluster genes in T-ALL and may contribute to the pathogenesis of the disease. We screened a panel of ALL and AML cell lines for <it>SET-NUP214 </it>expression to find model systems that might help to elucidate the cellular function of this fusion gene.</p> <p>Results</p> <p>Of 141 human leukemia/lymphoma cell lines tested, only the T-ALL cell line LOUCY and the AML cell line MEGAL expressed the <it>SET(TAF-</it>Iβ)-<it>NUP214 </it>fusion gene transcript. RT-PCR analysis specifically recognizing the alternative first exons of the two <it>TAF-</it>I isoforms revealed that the cell lines also expressed <it>TAF-</it>Iα-<it>NUP214 </it>mRNA. Results of fluorescence in situ hybridization (FISH) and array-based copy number analysis were both consistent with del(9)(q34.11q34.13) as described. Quantitative genomic PCR also confirmed loss of genomic material between <it>SET </it>and <it>NUP214 </it>in both cell lines. Genomic sequencing localized the breakpoints of the <it>SET </it>gene to regions downstream of the stop codon and to <it>NUP214 </it>intron 17/18 in both LOUCY and MEGAL cells. Both cell lines expressed the 140 kDa SET-NUP214 fusion protein.</p> <p>Conclusion</p> <p>Cell lines LOUCY and MEGAL express the recently described <it>SET-NUP214 </it>fusion gene. Of special note is that the formation of the <it>SET </it>exon 7/<it>NUP214 </it>exon 18 gene transcript requires alternative splicing as the <it>SET </it>breakpoint is located downstream of the stop codon in exon 8. The cell lines are promising model systems for <it>SET-NUP214 </it>studies and should facilitate investigating cellular functions of the the SET-NUP214 protein.</p
Experimental results on strangeness production in proton-proton collisions at COSY
The production of K+ and K- mesons in elementary proton-proton collision has
been investigated at the Cooler Synchrotron COSY in Juelich. A high quality
proton beam with low emittance and small momentum spread permitted to study the
creation of these mesons very close to the kinematical threshold. The energy
dependence of the total cross section is investigated using internal beam
facilities providing a high accuracy particle momentum determination as well as
an external non-magnetic detection setup with a large geometrical acceptance.
The determination of the four-momentum vectors for all ejectiles of each
registered event gives the complete kinematical information allowing to study
the interaction of the outgoing particles. Results on the performed studies of
the pp --> pp K+ K-, pp --> p Lambda K+ and pp --> p Sigma0 K+ reactions will
be presented and their relevance to the interpretation of heavy ion collisions
will be discussed.Comment: 8 pages, 6 figures, plenary talk at 6th International Conference On
Strange Quarks in Matter: '2001 - A Flavorspace Odyssey' (SQM2001),
Frankfurt, Germany, September 25-29, 2001, to be published in J. Phys. G:
Nucl. Part. Phy
MicroRNA-101 expression is associated with JAK2V617F activity and regulates JAK2/STAT5 signaling.
Philadelphia negative myeloproliferative neopl 28 asms (MPNs) are clonal haematological diseases characterized by excessive production of mature blood cells. Exome sequencing of patient samples have showed a relatively low degree genomic complexity for these diseases1. The majority of MPN patients carry somatic mutations in the JAK2 gene, with the JAK2V617F missense mutation being the most common in poly33
cythemia vera (PV, 95%) and essential thrombocythemia (ET, 60%) 2.FP was supported by Fondazione Umberto Veronesi, and Institute Pasteur - Fondazione Cenci Bolognetti
Total and Differential Cross Sections for the pp-->pp eta-prime Reaction Near Threshold
The eta-prime meson production in the reaction pp-->pp eta-prime has been
studied at excess energies of Q = 26.5, 32.5 and 46.6 MeV using the internal
beam facility COSY-11 at the cooler synchrotron COSY. The total cross sections
as well as one angular distribution for the highest Q-value are presented. The
excitation function of the near threshold data can be described by a pure
s-wave phase space distribution with the inclusion of the proton-proton final
state interaction and Coulomb effects. The obtained angular distribution of the
eta-prime mesons is also consistent with pure s-wave production.Comment: 6 pages, 5 figures, submitted to Eur. Phys. J.
Near-Threshold eta Meson Production in Proton-Proton Collisions
The production of eta mesons has been measured in the proton-proton
interaction close to the reaction threshold using the COSY-11 internal facility
at the cooler synchrotron COSY. Total cross sections were determined for eight
different excess energies in the range from 0.5 MeV to 5.4 MeV. The energy
dependence of the total cross section is well described by the available
phase-space volume weighted by FSI factors for the proton-proton and proton-eta
pairs.Comment: 9 pages, 1 table, 5 figure
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