An investigation of the SNS Josephson junction as a three-terminal device

A particular phenomenon of the SNS Josephson junction was investigated; i.e., control by a current entering the normal region and leaving through one of the superconducting regions. The effect of the control current on the junction was found to be dependent upon the ration of the resistances of the two halves of the N layer. A low frequency, lumped, nonlinear model was proposed to describe the electrical characteristics of the device, and a method was developed to plot the dynamic junction resistance as a function of junction current. The effective thermal noise temperature of the sample was determined. Small signal linearized analysis of the device suggests its use as an impedance transformer, although geometric limitations must be overcome. Linear approximation indicates that it is reciprocal and no power gain is possible. It is felt that, with suitable metallurgical and geometrical improvements, the device has promise to become a superconducting transistor

Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites

Background information The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system. The parasite, therefore, is entirely responsible for mediating vesicular transport within itself and in the infected erythrocyte cytoplasm, and it does so in part via its family of 11 Rab GTPases. Putative functions have been ascribed to Plasmodium Rabs due to their homology with Rabs of yeast, particularly with Saccharomyces that has an equivalent number of rab/ypt genes and where analyses of Ypt function is well characterized. Results Rabs are important regulators of vesicular traffic due to their capacity to recruit specific effectors. In order to identify P. falciparum Rab (PfRab) effectors, we first built a Ypt-interactome by exploiting genetic and physical binding data available at the Saccharomyces genome database (SGD). We then constructed a PfRab-interactome using putative parasite Rab-effectors identified by homology to Ypt-effectors. We demonstrate its potential by wet-bench testing three predictions; that casein kinase-1 (PfCK1) is a specific Rab5B interacting protein and that the catalytic subunit of cAMP-dependent protein kinase A (PfPKA-C) is a PfRab5A and PfRab7 effector. Conclusions The establishment of a shared set of physical Ypt/PfRab-effector proteins sheds light on a core set Plasmodium Rab-interactants shared with yeast. The PfRab-interactome should benefit vesicular trafficking studies in malaria parasites. The recruitment of PfCK1 to PfRab5B+ and PfPKA-C to PfRab5A+ and PfRab7+ vesicles, respectively, suggests that PfRab-recruited kinases potentially play a role in early and late endosome function in malaria parasites

Nanopype: A modular and scalable nanopore data processing pipeline

Long-read third-generation nanopore sequencing enables researchers to now address a range of questions that are difficult to tackle with short read approaches. The rapidly expanding user base and continuously increasing throughput have sparked the development of a growing number of specialized analysis tools. However, streamlined processing of nanopore datasets using reproducible and transparent workflows is still lacking. Here we present Nanopype, a nanopore data processing pipeline that integrates a diverse set of established bioinformatics software while maintaining consistent and standardized output formats. Seamless integration into compute cluster environments makes the framework suitable for high-throughput applications. As a result, Nanopype facilitates comparability of nanopore data analysis workflows and thereby should enhance the reproducibility of biological insights

Manejo de doenças do mamoeiro.

O mamoeiro é afetado por um grande número de doenças. As de maior importância econômica são citadas a seguir: Viroses ? As viroses constituem o maior entrave à implantação da cultura do mamoeiro, por causa da dificuldade do seu controle e da necessidade de migração que elas impõem à essa cultura. As três mais importantes são: o vírus vírus-da-mancha-anelar do- mamoeiro, no Brasil conhecido como o mosaico-do-mamoeiro; o vírus-da-meleira; e o vírus-do-amarelo mamoeiro; vírus amarelo-letal.Curso

The electric dipole moment of the neutron from 2+1 flavor lattice QCD

We compute the electric dipole moment d_n of the neutron from a fully dynamical simulation of lattice QCD with 2+1 flavors of clover fermions and nonvanishing theta term. The latter is rotated into the pseudoscalar density in the fermionic action using the axial anomaly. To make the action real, the vacuum angle theta is taken to be purely imaginary. The physical value of d_n is obtained by analytic continuation. We find d_n = -3.8(2)(9) x 10^{-16} [theta e cm], which, when combined with the experimental limit on d_n, leads to the upper bound theta < 7.6 x 10^{-11}.Comment: 12 pages, 8 figures, matches PRL published versio

Plasma Magnetohydrodynamics and Energy Conversion

Contains reports on four research projects.United States Air Force, Aeronautical Systems Division (Contract AF33(616)-7624)United States Air Force, Aeronautical Systems Division, Aeronautical Accessories Laboratory, Wright-Patterson Air Force Base (Contract AF33(616)-7624

Impacto potencial das mudanças climáticas sobre as doenças do mamoeiro no Brasil.

Doenças causadas por fungos e oomicetos; Doenças causadas por vírus

O(d,d) invariance at two and three loops

We show that in a two-dimensional sigma-model whose fields only depend on one target space co-ordinate, the O(d,d) invariance of the conformal invariance conditions observed at one loop is preserved at two loops (in the general case with torsion) and at three loops (in the case without torsion).Comment: 21 pages. Plain Tex. Uses Harvmac ("b" option). Revised Version with references added and minor errors correcte

Heating up the cold bounce

Self-dual string cosmological models provide an effective example of bouncing solutions where a phase of accelerated contraction smoothly evolves into an epoch of decelerated Friedmann--Robertson--Walker expansion dominated by the dilaton. While the transition to the expanding regime occurs at sub-Planckian curvature scales, the Universe emerging after the bounce is cold, with sharply growing gauge coupling. However, since massless gauge bosons (as well as other massless fields) are super-adiabatically amplified, the energy density of the maximally amplified modes re-entering the horizon after the bounce can efficiently heat the Universe. As a consequence the gauge coupling reaches a constant value, which can still be perturbative.Comment: 28 pages, 13 figure

Nonsupersymmetric multibrane solutions

Gravity coupled to an arbitrary number of antisymmetric tensors and scalar fields in arbitrary space-time dimensions is studied in a context of general, static, spherically symmetric solutions with many orthogonally intersecting branes. Neither supersymmetry nor harmonic gauge is assumed. It is shown that the system reduces to a Toda-like system after an adequate redefinition of transverse radial coordinate $r$. Duality $r \to 1/r$ in the set of solutions is observed