Timing the Nearby Isolated Neutron Star RX J1856.5-3754

RX J1856.5-3754 is the X-ray brightest among the nearby isolated neutron stars. Its X-ray spectrum is thermal, and is reproduced remarkably well by a black-body, but its interpretation has remained puzzling. One reason is that the source did not exhibit pulsations, and hence a magnetic field strength--vital input to atmosphere models--could not be estimated. Recently, however, very weak pulsations were discovered. Here, we analyze these in detail, using all available data from the XMM-Newton and Chandra X-ray observatories. From frequency measurements, we set a 2-sigma upper limit to the frequency derivative of \dot\nu<1.3e-14 Hz/s. Trying possible phase-connected timing solutions, we find that one solution is far more likely than the others, and we infer a most probable value of \dot\nu=(-5.98+/-0.14)e-16 Hz/s. The inferred magnetic field strength is 1.5e13 G, comparable to what was found for similar neutron stars. From models, the field seems too strong to be consistent with the absence of spectral features for non-condensed atmospheres. It is sufficiently strong, however, that the surface could be condensed, but only if it is consists of heavy elements like iron. Our measurements imply a characteristic age of about 4 Myr. This is longer than the cooling and kinematic ages, as was found for similar objects, but at almost a factor ten, the discrepancy is more extreme. A puzzle raised by our measurement is that the implied rotational energy loss rate of about 3e30 erg/s is orders of magnitude smaller than what was inferred from the H-alpha nebula surrounding the source.Comment: 4 pages, 2 figures, 2 tables; accepted for publication in Astrophysical Journal (Letters

Electrodynamics of Magnetars III: Pair Creation Processes in an Ultrastrong Magnetic Field and Particle Heating in a Dynamic Magnetosphere

We consider the details of the QED processes that create electron-positron pairs in magnetic fields approaching and exceeding 10^{14} G. The formation of free and bound pairs is addressed, and the importance of positronium dissociation by thermal X-rays is noted. We calculate the collision cross section between an X-ray and a gamma ray, and point out a resonance in the cross section when the gamma ray is close to the threshold for pair conversion. We also discuss how the pair creation rate in the open-field circuit and the outer magnetosphere can be strongly enhanced by instabilities near the light cylinder. When the current has a strong fluctuating component, a cascade develops. We examine the details of particle heating, and show that a high rate of pair creation can be sustained close to the star, but only if the spin period is shorter than several seconds. The dissipation rate in this turbulent state can easily accommodate the observed radio output of the transient radio-emitting magnetars, and even their infrared emission. Finally, we outline how a very high rate of pair creation on the open magnetic field lines can help to stabilize a static twist in the closed magnetosphere and to regulate the loss of magnetic helicity by reconnection at the light cylinder.Comment: 25 pages, submitted to the Astrophysical Journa

Multimodal transcriptional control of pattern formation in embryonic development

Predicting how interactions between transcription factors and regulatory DNA sequence dictate rates of transcription and, ultimately, drive developmental outcomes remains an open challenge in physical biology. Using stripe 2 of the even-skipped gene in Drosophila embryos as a case study, we dissect the regulatory forces underpinning a key step along the developmental decision-making cascade: the generation of cytoplasmic mRNA patterns via the control of transcription in individual cells. Using live imaging and computational approaches, we found that the transcriptional burst frequency is modulated across the stripe to control the mRNA production rate. However, we discovered that bursting alone cannot quantitatively recapitulate the formation of the stripe and that control of the window of time over which each nucleus transcribes even-skipped plays a critical role in stripe formation. Theoretical modeling revealed that these regulatory strategies (bursting and the time window) respond in different ways to input transcription factor concentrations, suggesting that the stripe is shaped by the interplay of 2 distinct underlying molecular processes

Technologies for Interoperable Internet of Medical Things Platforms to Manage Medical Emergencies in Home and Prehospital Care: Protocol for a Scoping Review

Background: Population growth and aging have highlighted the need for more effective home and prehospital care. Interconnected medical devices and applications, which comprise an infrastructure referred to as the Internet of Medical Things (IoMT), have enabled remote patient monitoring and can be important tools to cope with these demographic changes. However, developing IoMT platforms requires profound knowledge of clinical needs and challenges related to interoperability and how these can be managed with suitable technologies. Objective: The purpose of this scoping review is to summarize the best practices and technologies to overcome interoperability concerns in IoMT platform development for medical emergencies in home and prehospital care. Methods: This scoping review will be conducted in accordance with Arksey and O\u27Malley\u27s 5-stage framework and adhere to the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols) guidelines. Only peer-reviewed articles published in English will be considered. The databases/web search engines that will be used are IEEE Xplore, PubMed, Scopus, Google Scholar, National Center for Biotechnology Information, SAGE Journals, and ScienceDirect. The search process for relevant literature will be divided into 4 different steps. This will ensure that a suitable approach is followed in terms of search terms, limitations, and eligibility criteria. Relevant articles that meet the inclusion criteria will be screened in 2 stages: abstract and title screening and full-text screening. To reduce selection bias, the screening process will be performed by 2 reviewers. Results: The results of the preliminary search indicate that there is sufficient literature to form a good foundation for the scoping review. The search was performed in April 2022, and a total of 4579 articles were found. The main clinical focus is the prevention and management of falls, but other medical emergencies, such as heart disease and stroke, are also considered. Preliminary results show that little attention has been given to real-time IoMT platforms that can be deployed in real-world care settings. The final results are expected to be presented in a scoping review in 2023 and will be disseminated through scientific conference presentations, oral presentations, and publication in a peer-reviewed journal. Conclusions: This scoping review will provide insights and recommendations regarding how interoperable real-time IoMT platforms can be developed to handle medical emergencies in home and prehospital care. The findings of this research could be used by researchers, clinicians, and implementation teams to facilitate future development and interdisciplinary discussions

Radiation Hardness of Thin Low Gain Avalanche Detectors

Low Gain Avalanche Detectors (LGAD) are based on a n++-p+-p-p++ structure where an appropriate doping of the multiplication layer (p+) leads to high enough electric fields for impact ionization. Gain factors of few tens in charge significantly improve the resolution of timing measurements, particularly for thin detectors, where the timing performance was shown to be limited by Landau fluctuations. The main obstacle for their operation is the decrease of gain with irradiation, attributed to effective acceptor removal in the gain layer. Sets of thin sensors were produced by two different producers on different substrates, with different gain layer doping profiles and thicknesses (45, 50 and 80 um). Their performance in terms of gain/collected charge and leakage current was compared before and after irradiation with neutrons and pions up to the equivalent fluences of 5e15 cm-2. Transient Current Technique and charge collection measurements with LHC speed electronics were employed to characterize the detectors. The thin LGAD sensors were shown to perform much better than sensors of standard thickness (~300 um) and offer larger charge collection with respect to detectors without gain layer for fluences <2e15 cm-2. Larger initial gain prolongs the beneficial performance of LGADs. Pions were found to be more damaging than neutrons at the same equivalent fluence, while no significant difference was found between different producers. At very high fluences and bias voltages the gain appears due to deep acceptors in the bulk, hence also in thin standard detectors

Feature integration in natural language concepts

Two experiments measured the joint influence of three key sets of semantic features on the frequency with which artifacts (Experiment 1) or plants and creatures (Experiment 2) were categorized in familiar categories. For artifacts, current function outweighed both originally intended function and current appearance. For biological kinds, appearance and behavior, an inner biological function, and appearance and behavior of offspring all had similarly strong effects on categorization. The data were analyzed to determine whether an independent cue model or an interactive model best accounted for how the effects of the three feature sets combined. Feature integration was found to be additive for artifacts but interactive for biological kinds. In keeping with this, membership in contrasting artifact categories tended to be superadditive, indicating overlapping categories, whereas for biological kinds, it was subadditive, indicating conceptual gaps between categories. It is argued that the results underline a key domain difference between artifact and biological concepts

What determines auditory similarity? The effect of stimulus group and methodology.

Two experiments on the internal representation of auditory stimuli compared the pairwise and grouping methodologies as means of deriving similarity judgements. A total of 45 undergraduate students participated in each experiment, judging the similarity of short auditory stimuli, using one of the methodologies. The experiments support and extend Bonebright's (1996) findings, using a further 60 stimuli. Results from both methodologies highlight the importance of category information and acoustic features, such as root mean square (RMS) power and pitch, in similarity judgements. Results showed that the grouping task is a viable alternative to the pairwise task with N > 20 sounds whilst highlighting subtle differences, such as cluster tightness, between the different task results. The grouping task is more likely to yield category information as underlying similarity judgements

Autologous, lentivirus-modified, T-rapa cell “micropharmacies” for lysosomal storage disorders

T cells are the current choice for many cell therapy applications. They are relatively easy to access, expand in culture, and genetically modify. Rapamycin-conditioning ex vivo reprograms T cells, increasing their memory properties and capacity for survival, while reducing inflammatory potential and the amount of preparative conditioning required for engraftment. Rapamycin-conditioned T cells have been tested in patients and deemed to be safe to administer in numerous settings, with reduced occurrence of infusion-related adverse events. We demonstrate that ex vivo lentivirus-modified, rapamycin-conditioned CD4+ T cells can also act as next-generation cellular delivery vehicles—that is, “micropharmacies”—to disseminate corrective enzymes for multiple lysosomal storage disorders. We evaluated the therapeutic potential of this treatment platform for Fabry, Gaucher, Farber, and Pompe diseases in vitro and in vivo. For example, such micropharmacies expressing α-galactosidase A for treatment of Fabry disease were transplanted in mice where they provided functional enzyme in key affected tissues such as kidney and heart, facilitating clearance of pathogenic substrate after a single administration

X-ray spectra from magnetar candidates. I. Monte Carlo simulations in the non-relativistic regime

The anomalous X-ray pulsars and soft gamma-repeaters are peculiar high-energy sources believed to host a magnetar, i.e. an ultra-magnetized neutron star. Their persistent, soft X-ray emission (~1-10 keV)is usually modeled by the superposition of a blackbody and a power-law tail. It has been suggested that this spectrum forms as the thermal photons emitted by the star surface traverse the magnetosphere. Magnetar magnetospheres are likely different from those of ordinary radio-pulsars, since the external magnetic field may acquire a toroidal component as a consequence of the deformation of the star crust induced by the super-strong interior field. In turn, the magnetosphere will be permeated by currents that can boost primary photons through repeated scatterings. Here we present 3D Monte Carlo simulations of photon propagation in a twisted magnetosphere. Our model is based on a simplified treatment of the charge carriers velocity distribution which, however, accounts for the particle collective motion, in addition to the thermal one. Present treatment is restricted to conservative (Thomson) scattering in the electron rest frame. The code, nonetheless, is completely general and inclusion of the relativistic QED resonant cross section, which is required in the modeling of the hard (~20-200 keV) spectral tails observed in the magnetar candidates, is under way. The properties of emerging spectra have been assessed under different conditions, by exploring the model parameter space, including effects arising from the viewing geometry. Monte Carlo runs have been collected into a spectral archive. Two tabulated XSPEC spectral models, with and without viewing angles, have been produced and applied to the 0.1-10 keV XMM-Newton EPIC-pn spectrum of the AXP CXOU J1647-4552.Comment: 37 pages, 14 figures, 1 table; corrected typos; accepted for publication in MNRA