1,381 research outputs found

    Defects in SiO2 as the possible origin of near interface traps in the SiC∕SiO2 system: A systematic theoretical study

    Get PDF
    A systematic study of the level positions of intrinsic and carbon defects in SiO2 is presented, based on density functional calculations with a hybrid functional in an alpha-quartz supercell. The results are analyzed from the point of view of the near interface traps (NIT), observed in both SiC/SiO2 and Si/SiO2 systems, and assumed to have their origins in the oxide. It is shown that the vacancies and the oxygen interstitial can be excluded as the origin of such NIT, while the silicon interstitial and carbon dimers give rise to gap levels in the energy range inferred from experiments. The properties of these defects are discussed in light of the knowledge about the SiC/SiO2 interface

    Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

    Get PDF
    Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at sites of infection are incompletely characterized. T-cell death in cultures of peripheral blood mononuclear cells (PBMC) showed 'classic' features of apoptosis following exposure to pneumococci. Conversely, purified CD3(+) T-cells cultured with pneumococci demonstrated necrosis with membrane permeabilization. The death of purified CD3(+) T-cells was not inhibited by necrostatin, but required the bacterial toxin pneumolysin. Apoptosis of CD3(+) T-cells in PBMC cultures required 'classical' CD14(+) monocytes, which enhanced T-cell activation. CD3(+) T-cell death was enhanced in HIV-seropositive individuals. Monocyte-mediated CD3(+) T-cell apoptotic death was Fas-dependent both in vitro and in vivo. In the early stages of the T-cell dependent host response to pneumococci reduced Fas ligand mediated T-cell apoptosis was associated with decreased bacterial clearance in the lung and increased bacteremia. In summary monocytes converted pathogen-associated necrosis into Fas-dependent apoptosis and regulated levels of activated T-cells at sites of acute bacterial infection. These changes were associated with enhanced bacterial clearance in the lung and reduced levels of invasive pneumococcal disease

    Luminescence spectra of germanosilicate optical fibres I - radioluminescence and cathodoluminescence

    No full text
    Data are reported on the luminescence spectra generated by X-ray and electron irradiation of optical fibres, fibre preforms and silica. The impurities and imperfections in the fibre core have a higher luminescence efficiency than those in the substrate material. The core luminescence provides a major fraction of the total light emission, despite the fact that the core is a small fraction of the total fibre volume. A wide variety of overlapping emission bands are reported. The spectra are strongly temperature dependent but the component emission bands can generally be linked to either Ge impurities, giving the 400 nm band, exciton emission near 460 nm or other blue/UV bands linked to E'-type defects. Overall, the study of the fibre luminescence provides a sensitive technique for analysis d changes and repeatability of fibre fabrication

    A Brief History of Self-determination Referendums Before 1920

    Get PDF
    The article presents an account of the history of the discourses of self-determination referendums from 1552 to 1920. The referendum has played an important part in the discourse of self-determination since it was first pioneered by the French King Henry II in the sixteenth century. While the principle of self-determination expressed through plebiscites was mentioned en passant by Erasmus of Rotterdam, Grotius and Pufendorf, it was only after the French Revolution that the doctrine gained wider practical recognition. In the mid-nineteenth century the referendum was much debated and practised in Italy during the Risorgimento in the early twentieth century the doctrine was once again revived by Woodrow Wilson. But generally the principle was being used by statesmen in pursuit of narrow self-interest idealistic goals. This is an Accepted Manuscript of an article published by Taylor & Francis in Ethnopolitics on 2015, available online: http://www.tandfonline.com/ 10.1080/17449057.2015.105182

    Note and Comment

    Get PDF
    Freedom of Press and Use of the Mails - Strangely enough, the First Amendment to the Federal Constitution, although it guarantees against federal attack highly important and fundamental rights, has received very little authoritative interpretation by our courts. It remained for the Gr&t War and conditions following in its train to bring before that tribunal almost the first really important controversies relating to freedom of press and of speech. The case of U. S. ex rel. Milwaukee Social Democratic Publishing Company, Plaintiff in Error, v. Postmaster-General Albert S. Burleson, decided March 7, 192i, is the- latest of a series of notable cases concerning this important matter. The case, however, adds little to the development bf the subject by the court in the preceding cases in this group, which have been reviewed in an article by Professor Goodrich, I9 MICHIGAN LAw REvIEw, pages 487-501
    corecore