Characterisation of human glioma resections by Fast Field-Cycling NMR

abstract 58Peer reviewedPublisher PD

Analysis of human glioma by FFC NMR

Non peer reviewedPublisher PD

Synchronous Primary Tumors of the Kidney and Pancreas: Case Report

The simultaneous presence of primary carcinomas in the same patient is uncommon and synchronous primary tumors involving the kidney and pancreas are extremely rare. There are a few reports in the English literature of synchronous primary malignancies of the kidney and pancreas. We present a 62-year-old man who had weight loss of 9 kg and epigastric pain. Findings showed a Furhman grade II renal papillary carcinoma confined to the kidney and a synchronous well differentiated pancreatic ductal adenocarcinoma.Key Words: Synchronous double cancer, renal cell carcinoma, pancreatic carcinom

Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth.

Structural microtubule associated proteins (MAPs) stabilize microtubules, a property that was thought to be essential for development, maintenance and function of neuronal circuits. However, deletion of the structural MAPs in mice does not lead to major neurodevelopment defects. Here we demonstrate a role for MAP6 in brain wiring that is independent of microtubule binding. We find that MAP6 deletion disrupts brain connectivity and is associated with a lack of post-commissural fornix fibres. MAP6 contributes to fornix development by regulating axonal elongation induced by Semaphorin 3E. We show that MAP6 acts downstream of receptor activation through a mechanism that requires a proline-rich domain distinct from its microtubule-stabilizing domains. We also show that MAP6 directly binds to SH3 domain proteins known to be involved in neurite extension and semaphorin function. We conclude that MAP6 is critical to interface guidance molecules with intracellular signalling effectors during the development of cerebral axon tracts

Taurine: a potential marker of apoptosis in gliomas

New cancer therapies are being developed that trigger tumour apoptosis and an in vivo method of apoptotic detection and early treatment response would be of great value. Magnetic resonance spectroscopy (MRS) can determine the tumour biochemical profile in vivo, and we have investigated whether a specific spectroscopic signature exists for apoptosis in human astrocytomas. High-resolution magic angle spinning (HRMAS) 1H MRS provided detailed 1H spectra of brain tumour biopsies for direct correlation with histopathology. Metabolites, mobile lipids and macromolecules were quantified from presaturation HRMAS 1H spectra acquired from 41 biopsies of grades II (n=8), III (n=3) and IV (n=30) astrocytomas. Subsequently, TUNEL and H&E staining provided quantification of apoptosis, cell density and necrosis. Taurine was found to significantly correlate with apoptotic cell density (TUNEL) in both non-necrotic (R=0.727, P=0.003) and necrotic (R=0.626, P=0.0005) biopsies. However, the ca 2.8 p.p.m. polyunsaturated fatty acid peak, observed in other studies as a marker of apoptosis, correlated only in non-necrotic biopsies (R=0.705, P<0.005). We suggest that the taurine 1H MRS signal in astrocytomas may be a robust apoptotic biomarker that is independent of tumour necrotic status

Evaluation of Trivalent and Hexavalent Chromium Retention on Ain Oussera Soil by the Batch Method and Radiotracer Technique.

Major toxicology studies have concluded that Cr (VI) is a highly toxic carcinogen to living organisms, and cause deaths if ingested in large doses. The trivalent form plays an important role in glucose and lipid metabolism for human and animal diets. Industrial activities present in the study area investigated in this paper, such as tanning, production of paints, and cement, are the main sources of chromium in the soil and air, causing chromium pollution. The aim of this study is to investigate the behavior of Cr (III) and Cr (VI) in soil samples from the Ain Oussera area, using the batch method and radiotracer technique. This assessment of chromium adsorption in the soil allows us to examine its impact. The pH effects of initial concentration, adsorbent dose and temperature were investigated. Particle size, X-ray diffraction and neutron activation analysis methods were used to characterize the soil samples. Results of the Freundlich, and Langmuir isotherm models were compared to the obtained experimental data. The thermodynamic parameters ∆H°, ∆S° and ∆G° for the adsorption were determined by using four temperatures, 10, 30, 40 and 60°C. The adsorption process was spontaneous and favoured at a low temperature. The maximum adsorption percentage reached for Cr (III) and Cr (VI) in soil was 90 and 24, respectively, with a spontaneous reaction (∆H°< 0). These results show that hexavalent chromium seeps through soil layers, and reaches the groundwater easily

Evaluation of Trivalent and Hexavalent Chromium Retention on Ain Oussera Soil by the Batch Method and Radiotracer Technique.

Major toxicology studies have concluded that Cr (VI) is a highly toxic carcinogen to living organisms, and cause deaths if ingested in large doses. The trivalent form plays an important role in glucose and lipid metabolism for human and animal diets. Industrial activities present in the study area investigated in this paper, such as tanning, production of paints, and cement, are the main sources of chromium in the soil and air, causing chromium pollution. The aim of this study is to investigate the behavior of Cr (III) and Cr (VI) in soil samples from the Ain Oussera area, using the batch method and radiotracer technique. This assessment of chromium adsorption in the soil allows us to examine its impact. The pH effects of initial concentration, adsorbent dose and temperature were investigated. Particle size, X-ray diffraction and neutron activation analysis methods were used to characterize the soil samples. Results of the Freundlich, and Langmuir isotherm models were compared to the obtained experimental data. The thermodynamic parameters ∆H°, ∆S° and ∆G° for the adsorption were determined by using four temperatures, 10, 30, 40 and 60°C. The adsorption process was spontaneous and favoured at a low temperature. The maximum adsorption percentage reached for Cr (III) and Cr (VI) in soil was 90 and 24, respectively, with a spontaneous reaction (∆H°< 0). These results show that hexavalent chromium seeps through soil layers, and reaches the groundwater easily