57 research outputs found
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A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT
Boron-neutron capture therapy (BNCT) is an experimental radiation treatment modality used for highly malignant tumor treatments. Prior to irradiation with low energetic neutrons, a 10B compound is located selectively in the tumor cells. The effect of the treatment is based on the high LET radiation released in the {sup 10}B(n,{alpha}){sup 7}Li reaction with thermal neutrons. BNCT has been used experimentally for brain tumor and melanoma treatments. Lately applications of other severe tumor type treatments have been introduced. Results have shown that liver tumors can also be treated by BNCT. At Lawrence Berkeley National Laboratory, various compact neutron generators based on D-D or D-T fusion reactions are being developed. The earlier theoretical studies of the D-D or D-T fusion reaction based neutron generators have shown that the optimal moderator and reflector configuration for brain tumor BNCT can be created. In this work, the applicability of 2.5 MeV neutrons for liver tumor BNCT application was studied. The optimal neutron energy for external liver treatments is not known. Neutron beams of different energies (1eV < E < 100 keV) were simulated and the dose distribution in the liver was calculated with the MCNP simulation code. In order to obtain the optimal neutron energy spectrum with the D-D neutrons, various moderator designs were performed using MCNP simulations. In this article the neutron spectrum and the optimized beam shaping assembly for liver tumor treatments is presented
The comparison of four neutron sources for Prompt Gamma Neutron Activation Analysis (PGNAA) in vivo detections of boron
Therapeutic application of CCK2R-targeting PP-F11: influence of particle range, activity and peptide amount
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A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT
Genotypic variation in growth and resistance to insect herbivory in silver birch (Betula pendula) seedlings
Mortality in seedlings populations of Silver Birch: genotypic variation and herbivore effects
Resistance, growth and mortality in populations of silver birch seedlings: genotypic variation and herbivore effects
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