Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis

Endometriosis is a common chronic inflammatory condition in which endometrial tissue appears outside the uterine cavity. Because ectopic endometriosis cells express both estrogen and progesterone (P4) receptors, they grow and undergo cyclic proliferation and breakdown similar to the endometrium. This debilitating gynecological disease affects up to 15% of reproductive aged women. Despite many years of research, the etiopathogenesis of endometrial lesions remains unclear. Retrograde transport of the viable menstrual endometrial cells with retained ability for attachment within the pelvic cavity, proliferation, differentiation and subsequent invasion into the surrounding tissue constitutes the rationale for widely accepted implantation theory. Accordingly, the most abundant cells in the endometrium are endometrial stromal cells (EnSCs). These cells constitute a particular population with clonogenic activity that resembles properties of mesenchymal stem/stromal cells (MSCs). Thus, a significant role of stem cell-based dysfunction in formation of the initial endometrial lesions is suspected. There is increasing evidence that the role of epigenetic mechanisms and processes in endometriosis have been underestimated. The importance of excess estrogen exposure and P4 resistance in epigenetic homeostasis failure in the endometrial/endometriotic tissue are crucial. Epigenetic alterations regarding transcription factors of estrogen and P4 signaling pathways in MSCs are robust in endometriotic tissue. Thus, perspectives for the future may include MSCs and EnSCs as the targets of epigenetic therapies in the prevention and treatment of endometriosis. Here, we reviewed the current known changes in the epigenetic background of EnSCs and MSCs due to estrogen/P4 imbalances in the context of etiopathogenesis of endometriosis

Influence of Wearing Ballistic Vests on Physical Performance of Danish Police Officers: A Cross-Over Study

Purpose: We aimed to investigate the influence of wearing a ballistic vest on physical performance in police officers. Methods: We performed a cross-over study to investigate the influence of wearing a ballistic vest on reaction and response time, lumbar muscle endurance and police vehicle entry and exit times. Reaction and response time was based on a perturbation setup where the officers’ pelvises were fixed and EMG of lumbar and abdominal muscles was recorded. We used a modified Biering–Sørensen test to assess the lumbar muscle endurance and measured duration of entry and exit maneuvers in a variety of standard-issue police cars. Results: There was a significant difference of 24% in the lumbar muscle endurance test (no vest: 151 s vs. vest: 117 s), and the police officers experienced higher physical fatigue after the test when wearing a vest. Furthermore, officers took longer to both enter and exit police cars when wearing a vest (range: 0.24–0.56 s) depending on the model of the vehicle. There were no significant differences in reaction and response times between the test conditions (with/without vest). Discussion and Conclusion: Wearing of a ballistic vest significantly influenced the speed of movement in entry and exit of police cars and lumbar muscle endurance, although it does not seem to affect reaction or response times. The ballistic vest seems to impair performance of tasks that require maximal effort, which calls for better designs of such vests

From National to Cross-Border Support of Renewable Electricity in the European Union

The ability to cooperate in the expansion of renewable energies has long been recognized as welfare improving. However, the existing cooperation mechanisms introduced in the European Union appear to be insufficient to facilitate an efficient level of trade across borders. In this chapter we focus on the electricity sector and identify several characteristics of the market for renewable electricity support that contribute to this failure. We then propose a novel mechanism for cross-border support of renewable electricity capacity that addresses these failures in two steps: First, a cross-border impact factor is derived that provides an approximate indication of the spillover of benefits induced from renewable electricity capacity across the member states of the European Union. Second, a cross-border auction in which member states and generators of renewable electricity bid to either buy or supply additional renewable electricity capacity. The auctioneer uses the cross-border impact factor to determine the aggregate cross-border willingness to pay for additional renewable electricity capacity in each member state and selects the set of bids, which maximizes the EU-wide surplus. Inevitably, the design of the mechanism uses a simplified representation of the underlying system ‘reality’ in order to achieve the complexity reduction needed to create a ‘level playing field’, but in our view it would still represent cross-border impacts accurately enough to spur efficiency improvements in the right direction. Moreover, the fact that it could be integrated into the emerging market and regulatory framework in the European Union fairly easily is appealing