738 research outputs found
General technique of calculating drift velocity and diffusion coefficient in arbitrary periodic systems
We develop a practical method of computing the stationary drift velocity V
and the diffusion coefficient D of a particle (or a few particles) in a
periodic system with arbitrary transition rates. We solve this problem both in
a physically relevant continuous-time approach as well as for models with
discrete-time kinetics, which are often used in computer simulations. We show
that both approaches yield the same value of the drift, but the difference
between the diffusion coefficients obtained in each of them equals V*V/2.
Generalization to spaces of arbitrary dimension and several applications of the
method are also presented.Comment: 12 pages + 2 figures, RevTeX. Submitted to J. Phys. A: Math. Ge
The Performance of Alfalfa Synthetics in the First and Advanced Generations
During alfalfa breeding investigations conducted at the Nebraska Agricultural Experiment Station, numerous superior clones were selected and tested as clones, and in polycross progeny tests. Information was needed on the performance of synthetic varieties in the first and advanced generations, on the optimum number of clones to include in a synthetic variety, and on parent-progeny relationships. Clones with high general combining ability for forage yield as measured by polycross progeny tests, and in certain instances specific combining ability based on single-cross tests, were intercrossed in various ways to produce synthetic varieties. A group of synthetics varying in number of parents from 2 to 6 clones, having in some instances certain clones as common parents, was tested initially in the first generation of synthesis (referred to as Syn-1 from here on), later in the Syn-1 versus the Syn-2, and in some instances in the Syn-1, Syn-2, and Syn-3, and ultimately in the Syn-1,-2,-3, and -4 generations. The purposes of this bulletin are to report (1) comparative results obtained in yield trials involving the Syn-1,-2,-3, and -4 generations of 5 two-clone and 14 multiple-clone synthetics at Lincoln, Nebraska, and Ithaca, New York, and (2) parent-progeny relationships
Identification and characterization of small RNAs from the phloem of Brassica napus
Systemic signalling is indispensable for the coordination of diverse physiological processes during development, defence and nutrient allocation. Indirect evidence suggests that plant small RNAs (smRNAs) could be involved in long-distance information transfer via the vasculature of the plant. Analyses of the smRNA complements of vascular exudates from oilseed rape (Brassica napus) showed that xylem sap is devoid of RNA, whereas phloem sap contained a large number of smRNAs. In addition to 32 annotated microRNAs (miRNAs) from 18 different families that could be identified and approved, a set of unknown smRNAs, predominantly of 21 and 24 nucleotides in length, was obtained, and selected candidates were found to be highly abundant in phloem sap. Moreover, we could demonstrate that the levels of three miRNAs known to respond to nutrient deprivation in non-vascular tissue, miR395 (sulphate), miR398 (copper) and miR399 (phosphate), were increased in phloem sap during the growth of plants under the respective starvation conditions. Interestingly, only mature miRNA molecules were found to be stress responsive, demonstrating that single-stranded sense miRNAs are most likely to represent the physiologically relevant molecules. The strong responses in the phloem suggest a role of miRNAs in systemic information transfer via this long-distance transport system
Critical dimensions for random walks on random-walk chains
The probability distribution of random walks on linear structures generated
by random walks in -dimensional space, , is analytically studied
for the case . It is shown to obey the scaling form
, where is
the density of the chain. Expanding in powers of , we find that
there exists an infinite hierarchy of critical dimensions, ,
each one characterized by a logarithmic correction in . Namely, for
, ; for ,
; for , ; for , ; for , , {\it etc.\/} In particular, for
, this implies that the temporal dependence of the probability density of
being close to the origin .Comment: LATeX, 10 pages, no figures submitted for publication in PR
Continuum theory of vacancy-mediated diffusion
We present and solve a continuum theory of vacancy-mediated diffusion (as
evidenced, for example, in the vacancy driven motion of tracers in crystals).
Results are obtained for all spatial dimensions, and reveal the strongly
non-gaussian nature of the tracer fluctuations. In integer dimensions, our
results are in complete agreement with those from previous exact lattice
calculations. We also extend our model to describe the vacancy-driven
fluctuations of a slaved flux line.Comment: 25 Latex pages, subm. to Physical Review
Lattice gas model in random medium and open boundaries: hydrodynamic and relaxation to the steady state
We consider a lattice gas interacting by the exclusion rule in the presence
of a random field given by i.i.d. bounded random variables in a bounded domain
in contact with particles reservoir at different densities. We show, in
dimensions , that the rescaled empirical density field almost surely,
with respect to the random field, converges to the unique weak solution of a
non linear parabolic equation having the diffusion matrix determined by the
statistical properties of the external random field and boundary conditions
determined by the density of the reservoir. Further we show that the rescaled
empirical density field, in the stationary regime, almost surely with respect
to the random field, converges to the solution of the associated stationary
transport equation
Phospholipid Scramblase 4 (PLSCR4) Regulates Adipocyte Differentiation via PIP3-Mediated AKT Activation
Phospholipid scramblase 4 (PLSCR4) is a member of a conserved enzyme family with high relevance for the remodeling of phospholipid distribution in the plasma membrane and the regulation of cellular signaling. While PLSCR1 and -3 are involved in the regulation of adipose-tissue expansion, the role of PLSCR4 is so far unknown. PLSCR4 is significantly downregulated in an adipose-progenitor-cell model of deficiency for phosphatase and tensin homolog (PTEN). PTEN acts as a tumor suppressor and antagonist of the growth and survival signaling phosphoinositide 3-kinase (PI3K)/AKT cascade by dephosphorylating phosphatidylinositol-3,4,5-trisphosphate (PIP3). Patients with PTEN germline deletion frequently develop lipomas. The underlying mechanism for this aberrant adipose-tissue growth is incompletely understood. PLSCR4 is most highly expressed in human adipose tissue, compared with other phospholipid scramblases, suggesting a specific role of PLSCR4 in adipose-tissue biology. In cell and mouse models of lipid accumulation, we found PLSCR4 to be downregulated. We observed increased adipogenesis in PLSCR4-knockdown adipose progenitor cells, while PLSCR4 overexpression attenuated lipid accumulation. PLSCR4 knockdown was associated with increased PIP3 levels and the activation of AKT. Our results indicated that PLSCR4 is a regulator of PI3K/AKT signaling and adipogenesis and may play a role in PTEN-associated adipose-tissue overgrowth and lipoma formation
Motion of a driven tracer particle in a one-dimensional symmetric lattice gas
We study the dynamics of a tracer particle subject to a constant driving
force in a one-dimensional lattice gas of hard-core particles whose
transition rates are symmetric. We show that the mean displacement of the
driven tracer grows in time, , as , rather than the linear
time dependence found for driven diffusion in the bath of non-interacting
(ghost) particles. The prefactor is determined implicitly, as the
solution of a transcendental equation, for an arbitrary magnitude of the
driving force and an arbitrary concentration of the lattice gas particles. In
limiting cases the prefactor is obtained explicitly. Analytical predictions are
seen to be in a good agreement with the results of numerical simulations.Comment: 21 pages, LaTeX, 4 Postscript fugures, to be published in Phys. Rev.
E, (01Sep, 1996
Control of Tungiasis through Intermittent Application of a Plant-Based Repellent: An Intervention Study in a Resource-Poor Community in Brazil
Tungiasis is a parasitic skin disease caused by the female sand flea Tunga penetrans. The disease is frequent in resource-poor communities in South America and sub-Saharan Africa and affects the poorest of the poor. Sand flea disease is associated with a considerable morbidity and may lead to tetanus in non-vaccinated individuals. The degree of morbidity depends on the intensity of infestation, i.e., the number of embedded sand fleas a person has. Since tungiasis is a zoonosis involving a host of animal reservoirs, and because an effective treatment is not at hand, in resource-poor settings elimination is not feasible. Preventing morbidity to develop is therefore the only means to protect exposed individuals from sand flea disease. Similar to other arthropods, sand fleas can be repelled before they penetrate into the skin. In this study we show that the intermittent application of a plant-based repellent, of which the major component is coconut oil, reduces the intensity of infestation dramatically during the whole transmission season and prevents tungiasis-associated morbidity from developing. The prevention can be performed at the household level by the affected individuals themselves with minimal input from the health sector
Hopping Transport in the Presence of Site Energy Disorder: Temperature and Concentration Scaling of Conductivity Spectra
Recent measurements on ion conducting glasses have revealed that conductivity
spectra for various temperatures and ionic concentrations can be superimposed
onto a common master curve by an appropriate rescaling of the conductivity and
frequency. In order to understand the origin of the observed scaling behavior,
we investigate by Monte Carlo simulations the diffusion of particles in a
lattice with site energy disorder for a wide range of both temperatures and
concentrations. While the model can account for the changes in ionic activation
energies upon changing the concentration, it in general yields conductivity
spectra that exhibit no scaling behavior. However, for typical concentrations
and sufficiently low temperatures, a fairly good data collapse is obtained
analogous to that found in experiment.Comment: 6 pages, 4 figure
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