Digging Deeper: James Connolly in America

This project continued research into James Connolly\u27s time in America from 1902-1910. It focused on primary sources in the hopes to unearth things not found in the secondary writing on Connolly’s activities during this influential time. The O’Brien papers are an eclectic collection of primary documents from Connolly’s life, including letters between James Connolly and his friend John Matheson, correspondence with other socialists, and some of Connolly’s own writing. The New York Call was a daily socialist newspaper that contains ads for Connolly’s lectures and his magazine, The Harp, as well as meetings of his organization, the Irish Socialist Federation. Through these primary sources and others, more of James Connolly’s activities and perspectives during his time in America come to light

A Silk-Spinning Cave Larva

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Windows in the Milky Way

The objectives were twofold: (1) to study the IRAS emission levels in the vicinity of Baade's Window and in other optically transparent regions near the Galactic Center; and (2) to study the IRAS emission levels along sightlines in the Milky Way that exhibit very little CO emission. Tests were attempted to see whether the optically transparent 'windows' near the Galactic center can be identified (as FIR-weak regions) in the IRAS data base; and if so, whether the CO weak regions found elsewhere in the Milky Way represent similarly FIR weak and thus optically transparent sightlines through the Galaxy. The CO weak regions were also targeted in an effort to study the diffuse intercloud dust and its warming by the interstellar radiation field

Fall 1969

Massachusetts Lawn and Turf Grass CouncilBetter Turf Through Research and Education Artificial Turf Faces Credibility Gab by Dr. Gene C. Nutter (page 1) Nitrogen Facts and Fallacies by W.H. Garman (2) DDT Opponents by Charles Wurster, Jr. (10) DDT Defenders by Charles Wurster, Jr. (11) What Type 2,4-D to Use? by J.S. Coartney and A.H. Kates (21) Irrigation Circuit Break Pinpointed in One Hour (24

Progress in rational methods of cryoprotection in macromolecular crystallography

Measurements of the average thermal contractions (294→72 K) of 26 different cryosolutions are presented and discussed in conjunction with other recent advances in the rational design of protocols for cryogenic cooling in macromolecular crystallography

Haemophilus influenzae type b and Streptococcus pneumoniae as causes of pneumonia among children in Beijing, China.

To determine if Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae could be identified more often from the nasopharynx of patients with pneumonia than from control patients, we obtained nasopharyngeal swab specimens from 96 patients with chest x-ray-confirmed pneumonia and 214 age-matched control patients with diarrhea or dermatitis from the outpatient department at Beijing Children's Hospital. Pneumonia patients were more likely to be colonized with Hib and S. pneumoniae than control patients, even after the data were adjusted for possible confounding factors such as day-care attendance, the presence of other children in the household, and recent antibiotic use. In China, where blood cultures from pneumonia patients are rarely positive, the results of these nasopharyngeal cultures provide supporting evidence for the role of Hib and S. pneumoniae as causes of childhood pneumonia

A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding

BACKGROUND: The C-terminal tetratricopeptide (TPR) repeat domain of Pex5p recognises proteins carrying a peroxisomal targeting signal type 1 (PTS1) tripeptide in their C-terminus. Previously, structural data have been obtained from the TPR domain of Pex5p in both the liganded and unliganded states, indicating a conformational change taking place upon cargo protein binding. Such a conformational change would be expected to play a major role both during PTS1 protein recognition as well as in cargo release into the peroxisomal lumen. However, little information is available on the factors that may regulate such structural changes. RESULTS: We have used a range of biophysical and computational methods to further analyse the conformational flexibility and ligand binding of Pex5p. A new crystal form for the human Pex5p C-terminal domain (Pex5p(C)) was obtained in the presence of Sr(2+ )ions, and the structure presents a novel conformation, distinct from all previous liganded and apo crystal structures for Pex5p(C). The difference relates to a near-rigid body movement of two halves of the molecule, and this movement is different from that required to reach a ring-like conformation upon PTS1 ligand binding. The bound Sr(2+ )ion changes the dynamic properties of Pex5p(C) affecting its conformation, possibly by making the Sr(2+)-binding loop – located near the hinge region for the observed domain motions – more rigid. CONCLUSION: The current data indicate that Pex5p(C) is able to sample a range of conformational states in the absence of bound PTS1 ligand. The domain movements between various apo conformations are distinct from those involved in ligand binding, although the differences between all observed conformations so far can be characterised by the movement of the two halves of Pex5p(C) as near-rigid bodies with respect to each other

Assessment of Critical Habitats for Recovering the Chesapeake Bay Atlantic Sturgeon Distinct Population Segment

The states of Virginia and Maryland along with Virginia Commonwealth University (VCU), Virginia Institute of Marine Science (VIMS) and University of Maryland Center for Environmental Science (UMCES) partnered to assess critical habitat for recovering the Chesapeake Bay Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus) distinct population segment. The primary objectives were to assess reproductive habitat in the James River, nursery habitat in the James and York Rivers and the degree of dependence of those populations to habitat in the Chesapeake Bay