Neutrino masses, leptogenesis and dark matter in hybrid seesaw

We suggest a hybrid seesaw model where relatively ``light''right-handed neutrinos give no contribution to the neutrino mass matrix due to a special symmetry. This allows their Yukawa couplings to the standard model particles to be relatively strong, so that the standard model Higgs boson can decay dominantly to a left and a right-handed neutrino, leaving another stable right-handed neutrino as cold dark matter. In our model neutrino masses arise via the type-II seesaw mechanism, the Higgs triplet scalars being also responsible for the generation of the matter-antimatter asymmetry via the leptogenesis mechanism.Comment: 4 page

Next-Generation Antibody Therapeutics: Discovery, Development and Beyond: highlights of the third annual conference of the Chinese Antibody Society

The Chinese Antibody Society (CAS) convened the third annual conference in Cambridge, Massachusetts, USA on April 7, 2019. More than 600 global members attended the meeting. The theme of this conference was Next-Generation Antibody Therapeutics: Discovery, Development and Beyond. The meeting covered a vast variety of topics including cancer immunotherapy, single-domain antibodies as well as bispecific antibodies, immunotoxins, transgenic mouse platforms for next-generation monoclonal antibody discovery and antibody chemistry, manufacturing and controls (CMCs). Two hot topics were comprehensively discussed by the prestigious panelists and hosts at the panel discussions during the conferences, i.e., bispecific antibodies and antibody CMC

Constitutive model of AISI 1035 at high temperature

Use Gleeble-1500D thermal simulation test machine to conduct thermal tensile test on AISI 1035 in the deformation temperature range of 1 173,15~1 373,15 K and strain rate range of 0,2 ~ 20 s-1. Using the obtained true stress-strain curves, an intrinsic model of the material was constructed using a model considering strain compensation. The results showed that the correlation coefficient of the Arrhenius model of AISI 1035 considering strain compensation was 0,984 with an average absolute error of 3,550 %, which can accurately predict the flow profitability. The experimental data matched well with the prediction curves obtained from the model calculation, which verified the feasibility of the model

Numerical simulation of welding of intersecting line joints of 6061-T6 aluminum alloy bicycle frame

The joints of aluminum alloy frames are usually welded by manual TIG welding. In order to study the distribution law of welding stress level and welding temperature field of intersecting joints of 6061-T6 aluminum alloy bicycle frames, a intersecting joints model of welding parts was established by Finite Element Model (FEM), Software. Based on ABAQUS software, the welding temperature field and welding stress field were studied and analyzed by using direct thermal coupling method. The accuracy of welding simulation is fully verified, which can meet the simulation requirements required for the subsequent optimization process design, and achieve the purpose of shortening the time required for the accumulation of practical inspection

Granulocyte, granulocyte–macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells

We and other researchers have previously found that colony-stimulating factors (CSFs), which generally include granulocyte colony-stimulating factor (G-CSF), granulocyte–macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF), promote invasion by lung cancer cells. In the present study, we studied the effects of these CSFs on gelatinase production, urokinase plasminogen activator (uPA) production and their activity in human lung cancer cells. Gelatin zymographs of conditioned media derived from human lung adenocarcinoma cell lines revealed two major bands of gelatinase activity at 68 and 92 kDa, which were characterized as matrix metalloproteinase (MMP)-2 and MMP-9 respectively. Treatment with CSFs increased the 68- and 92-kDa activity and converted some of a 92-kDa proenzyme to an 82-kDa enzyme that was consistent with an active form of the MMP-9. Plasminogen activator zymographs of the conditioned media from the cancer cells showed that CSF treatment resulted in an increase in a 48–55 kDa plasminogen-dependent gelatinolytic activity that was characterized as human uPA. The conditioned medium from the cancer cells treated with CSFs stimulated the conversion of plasminogen to plasmin, providing a direct demonstration of the ability of enhanced uPA to increase plasmin-dependent proteolysis. The enhanced invasive behaviour of the cancer cells stimulated by CSFs was well correlated with the increase in MMPs and uPA activities. These data suggest that the enhanced production of extracellular matrix-degrading proteinases by the cancer cells in response to CSF treatment may represent a biochemical mechanism which promotes the invasive behaviour of the cancer cells. © 1999 Cancer Research Campaig

Constitutive model of AISI 1035 at high temperature

Use Gleeble-1500D thermal simulation test machine to conduct thermal tensile test on AISI 1035 in the deformation temperature range of 1 173,15~1 373,15 K and strain rate range of 0,2 ~ 20 s-1. Using the obtained true stress-strain curves, an intrinsic model of the material was constructed using a model considering strain compensation. The results showed that the correlation coefficient of the Arrhenius model of AISI 1035 considering strain compensation was 0,984 with an average absolute error of 3,550 %, which can accurately predict the flow profitability. The experimental data matched well with the prediction curves obtained from the model calculation, which verified the feasibility of the model

Numerical simulation of welding of intersecting line joints of 6061-T6 aluminum alloy bicycle frame

The joints of aluminum alloy frames are usually welded by manual TIG welding. In order to study the distribution law of welding stress level and welding temperature field of intersecting joints of 6061-T6 aluminum alloy bicycle frames, a intersecting joints model of welding parts was established by Finite Element Model (FEM), Software. Based on ABAQUS software, the welding temperature field and welding stress field were studied and analyzed by using direct thermal coupling method. The accuracy of welding simulation is fully verified, which can meet the simulation requirements required for the subsequent optimization process design, and achieve the purpose of shortening the time required for the accumulation of practical inspection

A Heckman selection model for the safety analysis of signalized intersections

published_or_final_versio