AMINO ACID SEQUENCES OF MOUSE COMPLEMENT C3 DERIVED FROM NUCLEOTIDE SEQUENCES OF CLONED cDNA a

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73374/1/j.1749-6632.1983.tb18118.x.pd

Experimental Studies of Hadronization and Parton Propagation in the Space-Time Domain

Over the past decade, new data have become available from DESY, Jefferson Lab, Fermilab, and RHIC that connect to parton propagation and hadron formation. Semi-inclusive DIS on nuclei, the Drell-Yan reaction, and heavy-ion collisions all bring different kinds of information on parton propagation within a medium, while the most direct information on hadron formation comes from the DIS data. Over the next decade one can hope to begin to understand these data within a unified picture. We briefly survey the most relevant data and the common elements of the physics picture, then highlight the new Jefferson Lab data from CLAS, and close with prospects for the future.Comment: 8 pages, 6 figures - To appear in the conference proceedings for Quark Matter 2009, March 30 - April 4, Knoxville, Tennesse

Structure and expression of the C3 gene

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46939/1/281_2004_Article_BF00205869.pd

Consecutive dosing of UVB irradiation induces loss of ABCB5 expression and activation of EMT and fibrosis proteins in limbal epithelial cells similar to pterygium epithelium

Pterygium pathogenesis is often attributed to a population of altered limbal stem cells, which initiate corneal invasion and drive the hyperproliferation and fibrosis associated with the disease. These cells are thought to undergo epithelial to mesenchymal transition (EMT) and to contribute to subepithelial stromal fibrosis. In this study, the presence of the novel limbal stem cell marker ABCB5 in clusters of basal epithelial pterygium cells co-expressing with P63α and P40 is reported. ABCB5-positive pterygium cells also express EMT-associated fibrosis markers including vimentin and α-SMA while their β-catenin expression is reduced. By using a novel in vitro model of two-dose UV-induced EMT activation on limbal epithelial cells, we could observe the dysregulation of EMT-related proteins including an increase of vimentin and α-SMA as well as downregulation of β-catenin in epithelial cells correlating to downregulation of ABCB5. The sequential irradiation of limbal fibroblasts also induced an increase in vimentin and α-SMA. Taken together, these data demonstrate for the first time the expression of ABCB5 in pterygium stem cell activity and EMT-related events while the involvement of limbal stem cells in pterygium pathogenesis is exhibited via sequential irradiation of limbal epithelial cells. The later in vitro approach can be used to further study the involvement of limbal epithelium UV-induced EMT in pterygium pathogenesis and help identify novel treatments against pterygium growth and recurrence

Multiple Parton Interactions in Z+4j, W\pm W\pm +0/2j and W+ W- +2j production at the LHC

The expected rate for Multiple Parton Interactions (MPI) at the LHC is large. This requires an estimate of their impact on all measurement foreseen at the LHC. Conversely it provides new means of studying MPI at the LHC. In this paper we examine the role of MPI at the LHC, with the design energy of 14 TeV, in - Z production in association with four jets, - W\pm W\pm in association with zero or two jets. -W+ W- in association with two jets. In all cases the vector bosons are assumed to decay leptonically. The MPI contribution to Z+4j is dominated by events with two jets with balancing transverse momentum. It is possible to achieve a good signal to background ratio, close to 20%, for MPI compared to Single Interaction processes by selecting events with two jets with large separation in the transverse plane. The corresponding statistical significance for a luminosity of 1 inverse fb is about 6.9 for the mu+mu- channel alone. The final state channel in which only two same-sign high transverse momentum charged leptons are required and additional hard jets are vetoed is dominated by MPI, with an expected yield of 2500 events with the full LHC luminosity.Comment: Accepted for publication in JHE

Forward Jets and Energy Flow in Hadronic Collisions

We observe that at the Large Hadron Collider, using forward + central detectors, it becomes possible for the first time to carry out calorimetric measurements of the transverse energy flow due to "minijets" accompanying production of two jets separated by a large rapidity interval. We present parton-shower calculations of energy flow observables in a high-energy factorized Monte Carlo framework, designed to take into account QCD logarithmic corrections both in the large rapidity interval and in the hard transverse momentum. Considering events with a forward and a central jet, we examine the energy flow in the interjet region and in the region away from the jets. We discuss the role of these observables to analyze multiple parton collision effects.Comment: 9 pages, 5 figures. Version2: added results on azimuthal distributions and more discussion of energy flow definition using jet clusterin

A Heavy Quark-Antiquark Pair in Hot QCD

Thermodynamics of a heavy quark-antiquark pair in SU(3)-QCD is studied both below and above the deconfinement critical temperature $T_c$. In the quenched case, a model of the string passing through heavy valence gluons yields a correct estimate of $T_c$ and the critical behavior of the string tension below $T_c$. For two light flavors, entropy and internal energy below $T_c$ can be obtained from the partition function of heavy-light mesons and baryons. To calculate the free energy of the system above $T_c$, we apply second-order perturbation theory in the interaction of the quark-gluon plasma constituents with the static quark-antiquark pair. The results for the entropy and internal energy, obtained both below and above $T_c$, are compared with recent lattice data.Comment: 27 pages, 16 figures; minor comments and references are added; version to appear in Nuclear Physics

Parton fragmentation in the vacuum and in the medium

We present the mini-proceedings of the workshop on ``Parton fragmentation in the vacuum and in the medium'' held at the European Centre for Theoretical Studies in Nuclear Physics and Related Areas (ECT*, Trento) in February 2008. The workshop gathered both theorists and experimentalists to discuss the current status of investigations of quark and gluon fragmentation into hadrons at different accelerator facilities (LEP, B-factories, JLab, HERA, RHIC, and Tevatron) as well as preparations for extension of these studies at the LHC. The main physics topics covered were: (i) light-quark and gluon fragmentation in the vacuum including theoretical (global fits analyses and MLLA) and experimental (data from e+e-, p-p, e-p collisions) aspects, (ii) strange and heavy-quark fragmentation, (iii) parton fragmentation in cold QCD matter (nuclear DIS), and (iv) medium-modified fragmentation in hot and dense QCD matter (high-energy nucleus-nucleus collisions). These mini-proceedings consist of an introduction and short summaries of the talks presented at the meeting.Comment: 43 pages, mini-proceedings Workshop ECT*, Trento, Feb. 25 - 29, 200