A new method for experimental characterisation of scattered radiation in 64-slice CT scanner

PURPOSE: The consummate 64-slice CT scanner that spawns a new generation of non-invasive diagnostic tool, however revolutionary, brings with it the incidental by-product that is scattered radiation. The extended detector aperture capability in the 64-slcie CT scanner allows the effects of scattered radiation to be more pronounced and therefore demands that the magnitude and spatial distribution of scatter component be addressed during the imaging process. To this end, corrective algorithms need to be formulated on a basis of a precise understanding of scatter distribution. Relative to a 64-slice CT scanner, here now a unique solution is based upon dedicated blockers operative within various detector rows, calculating scatter profiles and scatter to primary ratios (SPR). MATERIALS AND METHODS: A single dimension blocker array was installed beneath the collimator, and the extrapolated shadow area on the detectors revealed the scatter radiation after exposure. The experiment was conducted using a 64-slice CT scanner manufactured by GE Healthcare Technologies. RESULTS: Variables such as tube voltage, phantom size and phantom-off centring on the scatter profile and the SPR was measured using the dedicated blocker method introduced above. When tube voltage is increased from 80kVp to 140kVp in a 21.5 cm water phantom, the SPR is found to reduce from 219.9 to 39.9 respectively. CONCLUSION: The method developed within this study is applicable to any measurement and is direct with minimal complexity

The detection of single electrons by means of a Micromegas-covered MediPix2 pixel CMOS readout circuit

A small drift chamber was read out by means of a MediPix2 readout chip as direct anode. A Micromegas foil was placed 50 $\mu$m above the chip, and electron multiplication occurred in the gap. With a He/Isobutane 80/20 mixture, gas multiplication factors up to tens of thousands were achieved, resulting in an efficiency for detecting single electrons of better than 90% . We recorded many frames containing 2D images with tracks from cosmic muons. Along these tracks, electron clusters were observed, as well as delta-rays.Comment: 15 pages, 9 included postscript figures, 5 separate jpeg figures, submitted to Nucl. Instr. and Meth. A. A complete postscript version with high resolution figures 1, 3, 11, 12 and 14 can be found at http://www.nikhef.nl/~i06/RandD/final/letter4.p

Transmission analysis of a large tuberculosis outbreak in London: a mathematical modelling study using genomic data

Outbreaks of tuberculosis (TB) - such as the large isoniazid-resistant outbreak centred on London, UK, which originated in 1995 - provide excellent opportunities to model transmission of this devastating disease. Transmission chains for TB are notoriously difficult to ascertain, but mathematical modelling approaches, combined with whole-genome sequencing data, have strong potential to contribute to transmission analyses. Using such data, we aimed to reconstruct transmission histories for the outbreak using a Bayesian approach, and to use machine-learning techniques with patient-level data to identify the key covariates associated with transmission. By using our transmission reconstruction method that accounts for phylogenetic uncertainty, we are able to identify 21 transmission events with reasonable confidence, 9 of which have zero SNP distance, and a maximum distance of 3. Patient age, alcohol abuse and history of homelessness were found to be the most important predictors of being credible TB transmitters

Method of plant tissue culture and regeneration

Plants may be regenerated from stomatal cells or protoplasts of such cells. Prior to regeneration the cells or protoplasts may be genetically transformed by the introduction of hereditary material most preferably by a DNA construct which is free of genes which specify resistance to antibiotics. The regeneration step may include callus formation on a hormone-free medium. The method is particularly suitable for sugar beet

GridPix application to dual phase TPC

GridPix is a gas-filled detector with an aluminium mesh stretched 50 μm above the Timepix CMOS pixel chip. This defines a high electric field where gas amplification occurs. A feasibility study is ongoing at Nikhef for the application of the GridPix technology as a charge sensitive device in a dual phase noble gas Time Projection Chamber (TPC), within the framework of the DARWIN design study for next generation dark matter experiments. The smallness of the device and well defined materials allow for high radio-purity and low outgassing. The high granularity of a pixel readout and the high detection efficiency of single electrons of GridPix bring benefits especially in terms of energy resolution for small energy deposits. This feature is interesting also for the measurement of the scintillation yield and the ionisation yield of noble liquids. The accurate measurements of such quantities have a direct impact on the data interpretation of dark matter experiments. The application in dual phase argon or xenon TPCs implies several technological challenges, such as the survival of the device at cryogenic temperature as well as the operation in a pure noble gas atmosphere without discharges. We describe here the recent developments of the project

Mathematical modelling long-term effects of replacing Prevnar7 with Prevnar13 on invasive pneumococcal diseases in England and Wales

England and Wales recently replaced the 7-valent pneumococcal conjugate vaccine (PCV7) with its 13-valent equivalent (PCV13), partly based on projections from mathematical models of the long-term impact of such a switch compared to ceasing pneumococcal conjugate vaccination altogether. A compartmental deterministic model was used to estimate parameters governing transmission of infection and competition between different groups of pneumococcal serotypes prior to the introduction of PCV13. The best-fitting parameters were used in an individual based model to describe pneumococcal transmission dynamics and effects of various options for the vaccination programme change in England and Wales. A number of scenarios were conducted using (i) different assumptions about the number of invasive pneumococcal disease cases adjusted for the increasing trend in disease incidence prior to PCV7 introduction in England and Wales, and (ii) a range of values representing serotype replacement induced by vaccination of the additional six serotypes in PCV13. Most of the scenarios considered suggest that ceasing pneumococcal conjugate vaccine use would cause an increase in invasive pneumococcal disease incidence, while replacing PCV7 with PCV13 would cause an overall decrease. However, the size of this reduction largely depends on the level of competition induced by the additional serotypes in PCV13. The model estimates that over 20 years of PCV13 vaccination, around 5000–62000 IPD cases could be prevented compared to stopping pneumococcal conjugate vaccination altogether. Despite inevitable uncertainty around serotype replacement effects following introduction of PCV13, the model suggests a reduction in overall invasive pneumococcal disease incidence in all cases. Our results provide useful evidence on the benefits of PCV13 to countries replacing or considering replacing PCV7 with PCV13, as well as data that can be used to evaluate the cost-effectiveness of such a switch

Annual variability in the seasonal cycles of chlorophyll, nutrients and zooplankton on the North-West European continental shelf

Seasonal cycles of salinity, nutrients, chlorophyll and zooplankton at 8 locations on the West-European shelf were analysed with respect to their timing and magnitude in the period 1980-1984. A late spring bloom with low chlorophyll values (2-4 mg.m-³) is observed in the Irish Sea, off the Scottish east coast and the Channel entrance. An early spring bloom and relatively high chlorophyll values (7-12 mg.m-³) are found in the southern Bight and the Skagerrak, whereas a late spring bloom with high chlorophyll concentrations (24 mg.m-³) is found along the Dutch and Belgian coast. In contrast to the other regions, the peak of the phytoplankton cycle in the German Bight (Helgoland) occurs in the summer period instead of the spring period. The peak in the yearly abundance of copepods shifts from May-June in the south to July-August in the north of the shelf. In the Irish Sea and the Channel entrance two seasonal copepods peaks are observed. The January nitrate values in Irish Sea, the southern Bight and the Skagerrak are about 20 % higher than those in the Atlantic input signal in the Channel entrance and east off Scotland. The January DIP values in these regions are comparable to those of the input signal, but the Irish Sea forms an exception here the level is increased by 10-20%. If compared with the Atlantic input signal the January values for nitrate and DIP at the Dutch and Belgium coast are about 10 and 4, and in the German Bight (Helgoland) 4 and 3 times higher, respectively. At most sites changes in the seasonal cycles of chorophyll coincide with changes in nutrient concentrations, wheras the maximum level of the seasonal signal is related to the nutrient levels

The evaluation of an intervention based on the application of patient self-completion concordance forms in Dutch community pharmacies and the effect on adherence to chronic medication

Objective: To evaluate the use of patient self-completion concordance forms and to determine the effect of patient counselling by using concordance forms on adherence to chronic medication. Methods: Patients with a prescription for new chronic treatment were randomised in an intervention or control group. The intervention group received a concordance form to fill in at home and to discuss during a consultation 2 weeks later in the pharmacy. The control group received the Usual information and instruction on how to use the medicine. Afterwards, all patients were asked to fill in a questionnaire about their use of medicines and contact with the pharmacy employees. Adherence to the medicine was determined using rates of prescription refills after 6 months of use. Results: The questionnaires showed that patients were satisfied about the concordance model. After 6 months of use, 79% of the patients from both intervention and control group were defined as adherent. Conclusions: There was no significant difference found in adherence between intervention and control group. Practice implications: Use five selected questions from the concordance form which provided most answers. Focus on one drug group and have more consultation moments. (C) 2009 Elsevier Ireland Ltd. All rights reserved

Timing measurements with a 3D silicon sensor on Timepix3 in a 180 GeV/<i>c</i> hadron beam

Test beam measurements have been carried out with a 3D sensor on a Timepix3 ASIC and the time measurements are presented. The measurements are compared to those of a thin planar sensor on Timepix3. It is shown that for a perpendicularly incident beam the time resolution of both detectors is dominated by the Timepix3 front-end. The 3D detector is dominated by the time-to-digital conversion whereas the analog front-end jitter also gives a significant contribution for the thin planar detector. The 3D detector reaches an overall time resolution of 567 ± 6 ps compared to 683 ± 8 ps for the thin planar detector. For a grazing angle beam, however, the thin planar detector achieves a better time resolution because it has a lower pixel capacitance, and therefore suffers less from jitter in the analog front-end for the low charge signals that mainly occur in this type of measurement. Finally, it is also shown that the 3D and thin planar detector can achieve time resolutions for large clusters of about 100 ps and 250 ps, respectively, by combining many single hit measurements