Tests of Non-Causality Under Markov Assumptions for Qualitative Panel Data

For many years, social scientists have been interested in obtaining testable definitions of causality [C. W. Granger (1969)]. Recent works include those of G. Chamberlain (1982) and J. P. Florens and M. Mouchart (1982). The present paper first clarifies the results of these latter papers by considering a unifying definition of non-causality. Then, log-likelihood ratio (LR) tests for non-causality are derived for qualitative panel data under the minimal assumption that one series is Markov. LR tests for the Markov property are also obtained. Both test statistics have closed forms. These tests thus provide a readily applicable procedure for testing non-causality on qualitative panel data. Finally, the tests are applied to French Business Survey data in order to test the hypothesis that price changes from period to period are strictly exogenous to disequilibria appearing within periods

Tests of noncausality under Markov assumptions for qualitative panel data

For many years, social scientists have been interested in obtaining testable definitions of causality (Granger 1969, Sims 1972). Recent works include those of Chamberlain (1982) and Florens and Mouchart (1982). The present paper first clarifies the results of these latter papers by considering a unifying definition of noncausality. Then, log-likelihood ratio (LR) tests for noncausality are derived for qualitative panel data under the minimal assumption that one series is Markov. LR tests for the Markov property are also obtained. Both test statistics have closed forms. These tests thus provide a readily applicable procedure for testing noncausality on qualitative panel data. Finally, the tests are applied to French Business Survey data in order to test the hypothesis that price changes from period to period are strictly exogenous to disequilibria appearing within periods

Tests of Non-Causality Under Markov Assumptions for Qualitative Panel Data

For many years, social scientists have been interested in obtaining testable definitions of causality [C. W. Granger (1969)]. Recent works include those of G. Chamberlain (1982) and J. P. Florens and M. Mouchart (1982). The present paper first clarifies the results of these latter papers by considering a unifying definition of non-causality. Then, log-likelihood ratio (LR) tests for non-causality are derived for qualitative panel data under the minimal assumption that one series is Markov. LR tests for the Markov property are also obtained. Both test statistics have closed forms. These tests thus provide a readily applicable procedure for testing non-causality on qualitative panel data. Finally, the tests are applied to French Business Survey data in order to test the hypothesis that price changes from period to period are strictly exogenous to disequilibria appearing within periods

Phase Field Model for Three-Dimensional Dendritic Growth with Fluid Flow

We study the effect of fluid flow on three-dimensional (3D) dendrite growth using a phase-field model on an adaptive finite element grid. In order to simulate 3D fluid flow, we use an averaging method for the flow problem coupled to the phase-field method and the Semi-Implicit Approximated Projection Method (SIAPM). We describe a parallel implementation for the algorithm, using Charm++ FEM framework, and demonstrate its efficiency. We introduce an improved method for extracting dendrite tip position and tip radius, facilitating accurate comparison to theory. We benchmark our results for two-dimensional (2D) dendrite growth with solvability theory and previous results, finding them to be in good agreement. The physics of dendritic growth with fluid flow in three dimensions is very different from that in two dimensions, and we discuss the origin of this behavior

Interphase chromosome positioning in in vitro porcine cells and ex vivo porcine tissues

Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source are credited. The article was made available through the Brunel University Open Access Publishing Fund.BACKGROUND: In interphase nuclei of a wide range of species chromosomes are organised into their own specific locations termed territories. These chromosome territories are non-randomly positioned in nuclei which is believed to be related to a spatial aspect of regulatory control over gene expression. In this study we have adopted the pig as a model in which to study interphase chromosome positioning and follows on from other studies from our group of using pig cells and tissues to study interphase genome re-positioning during differentiation. The pig is an important model organism both economically and as a closely related species to study human disease models. This is why great efforts have been made to accomplish the full genome sequence in the last decade. RESULTS: This study has positioned most of the porcine chromosomes in in vitro cultured adult and embryonic fibroblasts, early passage stromal derived mesenchymal stem cells and lymphocytes. The study is further expanded to position four chromosomes in ex vivo tissue derived from pig kidney, lung and brain. CONCLUSIONS: It was concluded that porcine chromosomes are also non-randomly positioned within interphase nuclei with few major differences in chromosome position in interphase nuclei between different cell and tissue types. There were also no differences between preferred nuclear location of chromosomes in in vitro cultured cells as compared to cells in tissue sections. Using a number of analyses to ascertain by what criteria porcine chromosomes were positioned in interphase nuclei; we found a correlation with DNA content.This study is partly supported by Sygen International PLC

Rapid Sampling of Molecules via Skin for Diagnostic and Forensic Applications

Skin provides an excellent portal for diagnostic monitoring of a variety of entities; however, there is a dearth of reliable methods for patient-friendly sampling of skin constituents. This study describes the use of low-frequency ultrasound as a one-step methodology for rapid sampling of molecules from the skin. Sampling was performed using a brief exposure of 20 kHz ultrasound to skin in the presence of a sampling fluid. In vitro sampling from porcine skin was performed to assess the effectiveness of the method and its ability to sample drugs and endogenous epidermal biomolecules from the skin. Dermal presence of an antifungal drug—fluconazole and an abused substance, cocaine—was assessed in rats. Ultrasonic sampling captured the native profile of various naturally occurring moisturizing factors in skin. A high sampling efficiency (79 ± 13%) of topically delivered drug was achieved. Ultrasound consistently sampled greater amounts of drug from the skin compared to tape stripping. Ultrasonic sampling also detected sustained presence of cocaine in rat skin for up to 7 days as compared to its rapid disappearance from the urine. Ultrasonic sampling provides significant advantages including enhanced sampling from deeper layers of skin and high temporal sampling sensitivity

Characterization and social correlates of fecal testosterone and cortisol excretion in wild male Saguinus mystax

Reproductive success in male primates can be influenced by testosterone (T) and cortisol (C). We examined them in wild Saguinus mystax via fecal hormone analysis. Firstly, we wanted to characterize male hormonal status over the course of the year. Further we tested the influence of the reproductive status of the breeding female, social instability, and intergroup encounter rates on T levels, comparing the results with predictions of the challenge hypothesis (Wingfield et al., 1990). We also tested for interindividual differences in hormonal levels, possibly related to social or breeding status. We collected data during a 12-mo study on 2 groups of moustached tamarins at the Estación Biológica Quebrada Blanco in northeastern Peru. We found fairly similar T and C levels over the course of the year for all males. Yet an elevation of T shortly after the birth of infants, during the phase of ovarian inactivity of the group’s breeding female, was evident. Hormonal levels were not significantly elevated during a phase of social instability, did not correlate with intergroup encounter rates, and did not differ between breeding and nonbreeding males. Our results confirm the challenge hypothesis (Wingfield et al., 1990). The data suggest that reproductive competition inmoustached tamarins is not based on endocrinological, but instead on behavioral mechanisms, possibly combined with sperm competition.Deutsche Forschungsgemeinschaft (HE 1870/10-1,2