Uniaxial Tensile Stress-Strain Relationships of RC Elements Strengthened with FRP Sheets

The shear behavior of fiber-reinforced-polymer–strengthened reinforced concrete (FRP-strengthened RC) members is not fully developed and accurately predicted because of the lack of accurate constitutive laws for the components of the composite members. This paper presents experimental and analytical investigations of tensile stress-strain relationships of concrete and steel in FRP-strengthened RC members. These stress-strain relationships are required in formulations of softened truss models to predict the shear behavior of the FRP-strengthened RC element. Thirteen full-scale FRP-strengthened RC prismatic specimens with different FRP reinforcement ratios, steel reinforcement ratios, and FRP wrapping schemes were tested under uniaxial tension loading. The results show that the tensile behavior of the concrete and steel is altered because of the externally bonded FRP sheets. Modified constitutive laws are proposed and incorporated in the softened membrane model (SMM) to demonstrate through two tests the behavior of FRP-strengthened RC element subjected to pure shear. Moreover, crack spacing and crack width were studied and compared with existing code provisions

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

Abstract Background Chronic neuroinflammation is a hallmark of several neurological disorders associated with cognitive loss. Activated microglia and secreted factors such as tumor necrosis factor (TNF)-α are key mediators of neuroinflammation and may contribute to neuronal dysfunction. Our study was aimed to evaluate the therapeutic potential of a novel analog of thalidomide, 3,6'-dithiothalidomide (DT), an agent with anti-TNF-α activity, in a model of chronic neuroinflammation. Methods Lipopolysaccharide or artificial cerebrospinal fluid was infused into the fourth ventricle of three-month-old rats for 28 days. Starting on day 29, animals received daily intraperitoneal injections of DT (56 mg/kg/day) or vehicle for 14 days. Thereafter, cognitive function was assessed by novel object recognition, novel place recognition and Morris water maze, and animals were euthanized 25 min following water maze probe test evaluation. Results Chronic LPS-infusion was characterized by increased gene expression of the proinflammatory cytokines TNF-α and IL-1β in the hippocampus. Treatment with DT normalized TNF-α levels back to control levels but not IL-1β. Treatment with DT attenuated the expression of TLR2, TLR4, IRAK1 and Hmgb1, all genes involved in the TLR-mediated signaling pathway associated with classical microglia activation. However DT did not impact the numbers of MHC Class II immunoreactive cells. Chronic neuroinflammation impaired novel place recognition, spatial learning and memory function; but it did not impact novel object recognition. Importantly, treatment with DT restored cognitive function in LPS-infused animals and normalized the fraction of hippocampal neurons expressing the plasticity-related immediate-early gene Arc. Conclusion Our data demonstrate that the TNF-α synthesis inhibitor DT can significantly reverse hippocampus-dependent cognitive deficits induced by chronic neuroinflammation. These results suggest that TNF-α is a critical mediator of chronic neuroinflammation-induced neuronal dysfunction and cognitive impairment and targeting its synthesis could provide an effective therapeutic approach to several human neurodegenerative diseases

Interdisciplinary Graduate Experience: Lessons Learned

Engineers interact in the workplace with technical peers in other disciplines at all stages of design, development, and application. Awareness of the constraints and needs of the other disciplines can be key in many situations. Such interdisciplinary activity and the associated communication are facilitated if the all participants have a solid knowledge of discipline-specific terminology and an understanding of connecting concepts. Consequently, experience relating to interdisciplinary teamwork is a necessary component of engineering education. The Smart Engineering Group at the University of Missouri-Rolla was established to conduct interdisciplinary research and to create interdisciplinary educational resources. The topical interest area is smart structures which requires the integration of materials, structures, sensing, signal processing, manufacturing, etc. The interdisciplinary research and educational activities of the group, the assessment of those activities, and the experiences of several graduate students will be described. The effectiveness of collaborative student work was tied to the students- understanding of the needed synergy and their comfort with cross-disciplinary communication. Also, an interdisciplinary course, which grew out of the group-s experiences, provided systematic preparation for graduate research projects. The role of this course will be discussed as it relates to the quality of collaborative experiences from both student and faculty perspectives

Rubble Pile Characterization Model

Rubble piles created following the collapse of a building in a combat situation can significantly impact mission accomplishment, particularly in the area of movement and maneuver. Rubble characteristics must be known, for example, in order to predict the ability of a vehicle to override the collateral damage from weapon effects in urban areas. Two types of models are developed: a first-order model and a first-principles-based model. In both models, we assume complete rubblization of the building and develop a rubble profile model using the size and composition of the collapsed structure to predict the rubble volume. In both cases, this profile model includes the size of the footprint area surrounding the original building assuming that the rubble is free to expand horizontally as well as the resulting height of such a rubble pile. Empirical data is now needed to verify the predictive capabilities of these models

Continuous Concrete Beams Reinforced With CFRP Bars.

yesThis paper reports the testing of three continuously and two simply supported concrete beams reinforced with carbon fibre reinforced polymer (CFRP) bars. The amount of CFRP reinforcement in beams tested was the main parameter investigated. A continuous concrete beam reinforced with steel bars was also tested for comparison purposes. The ACI 440.1R-06 equations are validated against the beam test results. Test results show that increasing the CFRP reinforcement ratio of the bottom layer of simply and continuously supported concrete beams is a key factor in enhancing the load capacity and controlling deflection. Continuous concrete beams reinforced with CFRP bars exhibited a remarkable wide crack over the middle support that significantly influenced their behaviour. The load capacity and deflection of CFRP simply supported concrete beams are reasonably predicted using the ACI 440.1R-06 equations. However, the potential capabilities of these equations for predicting the load capacity and deflection of continuous CFRP reinforced concrete beams have been adversely affected by the de-bonding of top CFRP bars from concrete

The African Network for Improved Diagnostics, Epidemiology and Management of common infectious Agents

In sub-Saharan Africa, acute respiratory infections (ARI), acute gastrointestinal infections (GI) and acute febrile disease of unknown cause (AFDUC) have a large disease burden, especially among children, while respective aetiologies often remain unresolved. The need for robust infectious disease surveillance to detect emerging pathogens along with common human pathogens has been highlighted by the ongoing novel coronavirus disease2019 (COVID-19) pandemic. The African Network for Improved Diagnostics, Epidemiology and Management of Common Infectious Agents (ANDEMIA) is a sentinel surveillance study on the aetiology and clinical characteristics of ARI, GI and AFDUC in sub-Saharan Africa.Peer Reviewe

The status of hepatitis C virus infection among people who inject drugs in the Middle East and North Africa.

BACKGROUND AND AIMS: People who inject drugs (PWID) are a key population at high risk of hepatitis C virus (HCV) infection. The aim of this study was to delineate the epidemiology of HCV in PWID in the Middle East and North Africa (MENA). METHODS: Syntheses of data were conducted on the standardized and systematically assembled databases of the MENA HCV Epidemiology Synthesis Project, 1989-2018. Random-effects meta-analyses and meta-regressions were performed. Meta-regression variables included country, study site, year of data collection and year of publication [to assess trends in HCV antibody prevalence over time], sample size and sampling methodology. Numbers of chronically infected PWID across MENA were estimated. The Shannon Diversity Index was calculated to assess genotype diversity. RESULTS: Based on 118 HCV antibody prevalence measures, the pooled mean prevalence in PWID for all MENA was 49.3% [95% confidence interval (CI) = 44.4-54.1%]. The country-specific pooled mean ranged from 21.7% (95% CI = 4.9-38.6%) in Tunisia to 94.2% (95% CI = 90.8-96.7%) in Libya. An estimated 221 704 PWID were chronically infected, with the largest numbers found in Iran at 68 526 and in Pakistan at 46 554. There was no statistically significant evidence for a decline in HCV antibody prevalence over time. Genotype diversity was moderate (Shannon Diversity Index of 1.01 out of 1.95; 52.1%). The pooled mean percentage for each HCV genotype was highest in genotype 3 (42.7%) and in genotype 1 (35.9%). CONCLUSION: Half of people who inject drugs in the Middle East and North Africa appear to have ever been infected with hepatitis C virus, but there are large variations in antibody prevalence among countries. In addition to > 200 000 chronically infected current people who inject drugs, there is an unknown number of people who no longer inject drugs who may have acquired hepatitis C virus during past injecting drug use. Harm reduction services must be expanded, and innovative strategies need to be employed to ensure accessibility to hepatitis C virus testing and treatment