Cardiovascular, respiratory, gastrointestinal and behavioral effects of intravenous lidocaine in healthy, conscious horses and evaluation of the relationship with lidocaine and monoethylglycinexylidide serum concentrations

This study aimed to evaluate the relationship between the serum concentrations of lidocaine/ monoethylglycinexylidide (MEGX) and their effects on several systems in horses. Five healthy, conscious horses received a two-hour placebo intravenous infusion followed by a two-hour lidocaine infusion (bolus of 1.3 mg/kg over ten minutes followed by a continuous rate infusion of 0.05 mg/kg/min). Lidocaine and MEGX serum concentrations were sampled every ten to fifteen minutes during the experiment, and the presence of muscle fasciculations and loss of balance as well as the respiratory, digestive and cardiovascular systems of the five horses were evaluated by means of different non-invasive methods. During the lidocaine infusion, the mean (f SD) lidocaine and MEGX concentrations were respectively 768.88 +/- 93.32ng/ml and 163.08 +/- 108.98 ng/ml. The infusion of lidocaine significantly influenced the presence of fasciculations, caused a statistically but non-clinically significant decrease of systolic and diastolic blood pressures, which were both correlated with lidocaine and MEGX serum concentrations, and it increased the duodenal contractions frequency, which was correlated with the serum lidocaine concentration. In this study, mild hypotensive and prokinetic effects of short-term lidocaine infusion were observed

Decaying Sterile Neutrinos as a Heating Source in the Milky Way Center

Recent Chandra and Newton observations indicate that there are two-temperature components ($T \sim$ 8 keV, 0.8 keV) of the diffuse x-rays emitted from deep inside the center of Milky Way. We show that this can be explained by the existence of sterile neutrinos, which decay to emit photons that can be bound-free absorbed by the isothermal hot gas particles in the center of Milky Way. This model can account for the two-temperature components naturally as well as the energy needed to maintain the $\sim$ 8 keV temperature in the hot gas. The predicted sterile neutrino mass is between 16-18 keV.Comment: Accepted by MNRAS with minor correction

Equivalent layered models for functionally graded plates

Functionally graded plates whose material properties vary continuously through the thickness are modelled as exactly equivalent plates composed of up to four isotropic layers. Separate models are derived for analysis using classical plate theory, first-order and higher-order shear deformation theory. For cases where Poisson’s ratio varies through the thickness, the integrations required to obtain the membrane, coupling and out-of-plane stiffness matrices are performed accurately using a series solution. The model is verified by comparison with well converged solutions from approximate models in which the plate is divided into many isotropic layers. Critical buckling loads and undamped natural frequencies are found for a range of illustrative examples

Two experiments for the price of one? -- The role of the second oscillation maximum in long baseline neutrino experiments

We investigate the quantitative impact that data from the second oscillation maximum has on the performance of wide band beam neutrino oscillation experiments. We present results for the physics sensitivities to standard three flavor oscillation, as well as results for the sensitivity to non-standard interactions. The quantitative study is performed using an experimental setup similar to the Fermilab to DUSEL Long Baseline Neutrino Experiment (LBNE). We find that, with the single exception of sensitivity to the mass hierarchy, the second maximum plays only a marginal role due to the experimental difficulties to obtain a statistically significant and sufficiently background-free event sample at low energies. This conclusion is valid for both water Cherenkov and liquid argon detectors. Moreover, we confirm that non-standard neutrino interactions are very hard to distinguish experimentally from standard three-flavor effects and can lead to a considerable loss of sensitivity to \theta_{13}, the mass hierarchy and CP violation.Comment: RevTex 4.1, 23 pages, 10 figures; v2: Typos corrected, very minor clarifications; matches published version; v3: Fixed a typo in the first equation in sec. III

Preservation of macular structure and function after intravitreal aflibercept for choroidal neovascularization associated with serpiginous choroiditis

Lund Univ, Scane Cty Univ Hosp, Dept Ophthalmol, Clin Sci, Lund, SwedenKing Khalid Eye Specialist Hosp, Vitreoretinal Div, Riyadh, Saudi ArabiaOFTALMOLOGICA, San Miguel De Tucuman, ArgentinaFed Univ Sao Paulo UNIFESP, Dept Ophthalmol, Sao Paulo, BrazilJohns Hopkins Univ, Sch Med, Wilmer Eye Inst, Retina Div, Baltimore, MD 21205 USADepartment of Ophthalmology, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, BrazilWeb of Scienc

MiniBooNE

The physics motivations, design, and status of the Booster Neutrino Experiment at Fermilab, MiniBooNE, are briefly discussed. Particular emphasis is given on the ongoing preparatory work that is needed for the MiniBooNE muon neutrino to electron neutrino oscillation appearance search. This search aims to confirm or refute in a definitive and independent way the evidence for neutrino oscillations reported by the LSND experiment.Comment: 3 pages, no figures, to appear in the proceedings of the 9th International Conference on Astroparticle and Underground Physics (TAUP 2005), Zaragoza, Spain, 10-14 Sep 200

Phenomenology of Quantum Gravity and its Possible Role in Neutrino Anomalies

New phenomenological models of Quantum Gravity have suggested that a Lorentz-Invariant discrete spacetime structure may become manifest through a nonstandard coupling of matter fields and spacetime curvature. On the other hand, there is strong experimental evidence suggesting that neutrino oscillations cannot be described by simply considering neutrinos as massive particles. In this manuscript we motivate and construct one particular phenomenological model of Quantum Gravity that could account for the so-called neutrino anomalies.Comment: For the proceedings of "Relativity and Gravitation: 100 Years after Einstein in Prague" (June 2012, Prague

Seismic-scale petrophysical interpretation and gas-volume estimation from simultaneous impedance inversion

© 2017 by The Society of Exploration Geophysicists. Simultaneous impedance inversion was performed to obtain the seismic-scale P-and S-wave impedances as well as the bulk density volumes from seismic angle stacks at a siliciclastic turbidite offshore gas reservoir. To translate these variables into seismic-scale total porosity (φ), clay content, and water saturation (S w ), we used a deterministic rock-physics model established at the well. A crucial input into this model is the bulk modulus (K f ) of the brine/gas system. We need to link it to S w at the seismic scale. This link can be one of simple mixing laws, such as harmonic and arithmetic. Alternately, it can be derived at the well by using upscaled variables and ensuring that they obey the well-data-driven rock-physics model. These different K f -S w relations produce different interpretations for φ and S w thus allowing one to assess the variability in the estimates of the gas volume in place that is proportional to the product of φ and (1 - S w )

Leptonic CP violation studies at MiniBooNE in the (3+2) sterile neutrino oscillation hypothesis

We investigate the extent to which leptonic CP-violation in (3+2) sterile neutrino models leads to different oscillation probabilities for $\bar{\nu}_{\mu}\to\bar{\nu}_e$ and $\nu_{\mu}\to\nu_e$ oscillations at MiniBooNE. We are using a combined analysis of short-baseline (SBL) oscillation results, including the LSND and null SBL results, to which we impose additional constraints from atmospheric oscillation data. We obtain the favored regions in MiniBooNE oscillation probability space for both (3+2) CP-conserving and (3+2) CP-violating models. We further investigate the allowed CP-violation phase values and the MiniBooNE reach for such a CP violation measurement. The analysis shows that the oscillation probabilities in MiniBooNE neutrino and antineutrino running modes can differ significantly, with the latter possibly being as much as three times larger than the first. In addition, we also show that all possible values of the single CP-violation phase measurable at short baselines in (3+2) models are allowed within 99% CL by existing data.Comment: Fixed a typo following PRD Erratum. 8 pages, 5 figure