Chemokines: structure, receptors and functions. A new target for inflammation and asthma therapy?

Five to 10% of the human population have a disorder of the respiratory tract called ‘asthma’. It has been known as a potentially dangerous disease for over 2000 years, as it was already described by Hippocrates and recognized as a disease entity by Egyptian and Hebrew physicians. At the beginning of this decade, there has been a fundamental change in asthma management. The emphasis has shifted from symptom relief with bronchodilator therapies (e.g. β2-agonists) to a much earlier introduction of anti-inflammatory treatment (e.g. corticosteroids). Asthma is now recognized to be a chronic inflammatory disease of the airways, involving various inflammatory cells and their mediators. Although asthma has been the subject of many investigations, the exact role of the different inflammatory cells has not been elucidated completely. Many suggestions have been made and several cells have been implicated in the pathogenesis of asthma, such as the eosinophils, the mast cells, the basophils and the lymphocytes. To date, however, the relative importance of these cells is not completely understood. The cell type predominantly found in the asthmatic lung is the eosinophil and the recruitment of these eosinophils can be seen as a characteristic of asthma. In recent years much attention is given to the role of the newly identified chemokines in asthma pathology. Chemokines are structurally and functionally related 8–10 kDa peptides that are the products of distinct genes clustered on human chromosomes 4 and 17 and can be found at sites of inflammation. They form a superfamily of proinflammatory mediators that promote the recruitment of various kinds of leukocytes and lymphocytes. The chemokine superfamily can be divided into three subgroups based on overall sequence homology. Although the chemokines have highly conserved amino acid sequences, each of the chemokines binds to and induces the chemotaxis of particular classes of white blood cells. Certain chemokines stimulate the recruitment of multiple cell types including monocytes, lymphocytes, basophils, and eosinophils, which are important cells in asthma. Intervention in this process, by the development of chemokine antagonists, might be the key to new therapy. In this review we present an overview of recent developments in the field of chemokines and their role in inflammations as reported in literature

Evolutions in undirected travel (satisfaction) during the COVID-19 pandemic

The COVID-19 pandemic illustrated that undirected travel (UT), or trips taken for their own sake, can partly compensate for a reduction in destination-based trips due to governmental regulations. Consequently, UT (in general, but particularly during the pandemic) may be especially satisfying and therefore important to subjective well-being. However, through the course of the pandemic, changes in UT were anticipated as individuals adapted to a ‘new normal’. This research – conducted in Flanders, Belgium – first investigates whether the characteristics of and satisfaction with UT persisted after one year into the pandemic (April 2020 to May 2021) using longitudinal panel data from two waves (n = 332). Results of paired sample t-tests indicate that UT satisfaction increased though duration of trips decreased, and results of the Sign test indicate that the frequency of UT generally decreased. Second, this research investigates characteristics of individuals with different UT behavior. Six profiles of UT behavior were identified based on starting or stopping UT, increasing or decreasing UT, maintaining UT frequency, or not participating in UT. Chi2 tests identified differences among profiles based on wave 1 UT frequency, most recent trip mode, socio-demographic, and household characteristics. Results indicate that participation in UT might motivate future UT, one to three UT trips per week is a maintainable frequency, UT might be important to those with smaller living spaces and those living with children or other adults, and suggest that attention should be paid to mobility equity, including how and for whom systems are planned. These findings are important to understanding the effects of long-term governmental regulations in response to the COVID-19 pandemic on travel behavior, and how investigating UT might help to challenge and reimagine traditional mobility systems post-pandemic

On undirected trips, satisfaction, and well-being: Evidence from Flanders (Belgium)

Despite having the potential to improve subjective well-being, satisfaction with undirected travel, or travel for its own sake (e.g. taking a walk, bike ride, or joy ride), has not yet been empirically investigated. Using mean-comparison and generalized linear regression models, this study analyzes 1579 undirected trips made by 852 respondents to a survey in Flanders, Belgium during the COVID-19 pandemic lockdown (18 March – 4 May 2020). Undirected travel was found to be longer in duration and more satisfying than results from directed trips in previous literature, with an indication that higher levels of physical activity are important to satisfaction. Undirected travel satisfaction was found to have a clear positive relationship to well-being. As these trips are often active and were found to imply a positive utility of travel, understanding them can be important to policy goals regarding health, sustainability, and improving individual well-being

Photoemission investigation of the electronic structure of Fe-Pd and Fe-Pt alloys

A photoemission investigation of Fe-Pd and Fe-Pt transition-metal alloys, using ∼50–150-eV synchrotron radiation, is presented. We consider in particular the spectral distribution of Fe states when approaching the dilute limit. By means of the Cooper minimum in the 4d and 5d photoionization cross section, we identify structures that have mainly Fe minority- or Fe majority-spin character. The relative position of these peaks is discussed in terms of the covalent interaction between Fe 3d and Pd or Pt d states. Also, the strong resemblance between the distribution of Fe states in the Pd-based and in the Pt-based alloys is demonstrated. We find a consistent behavior of interacting d states towards the dilute limit. It is concluded that the Fe states that are observed in the photoemission spectra of the dilute alloys have mainly majority-spin character and are, because of the covalent interaction with host states, widely distributed over the energy range of the host d band. The Fe minority-spin band, which is centered near the Fermi level, gradually empties with increasing Fe dilution

Cardiac amyloidosis

The frequency of cardiac involvement varies among other types of amyloidosis. Cardiac amyloidosis leads to systolic and diastolic dysfunction with symptoms of heart failure. Cardiac magnetic resonance (CMR) findings are helpful in supporting the diagnosis of amyloid cardiomyopathy. We report a case of a 73-year-old man who presented with shortness of breath. Echocardiography showed a hypertrophic, diffusely hypocontractile left ventricle with a restrictive filling pattern. The diagnosis of an isolated amyloidosis was made on CMR

Late Gothic altarpieces as sources of information on medieval wood use: A dendrochronological and art historical survey

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Sakurai's Object: characterizing the near-infrared CO ejecta between 2003 and 2007

We present observations of Sakurai's Object obtained at 1–5 μm between 2003 and 2007. By fitting a radiative transfer model to an echelle spectrum of CO fundamental absorption features around 4.7 μm, we determine the excitation conditions in the line-forming region. We find 12C/13C = 3.5+2.0−1.5, consistent with CO originating in ejecta processed by the very late thermal pulse, rather than in the pre-existing planetary nebula. We demonstrate the existence of 2.2 × 10−6≤MCO≤ 2.7 × 10−6 M⊙ of CO ejecta outside the dust, forming a high-velocity wind of 500 ± 80 km s−1. We find evidence for significant weakening of the CO band and cooling of the dust around the central star between 2003 and 2005. The gas and dust temperatures are implausibly high for stellar radiation to be the sole contributor