The MS Symptom and Impact Diary (MSSID): psychometric evaluation of a new instrument to measure the day to day impact of multiple sclerosis

OBJECTIVES: This study aimed to develop further a diary originally devised to measure the impact of multiple sclerosis (MS) as part of a cost utility study of beta interferon, and to evaluate its reliability, validity, and responsiveness in an outpatient sample of people with MS. METHODS: The original diary was further developed using qualitative and quantitative methods to ensure that it addressed the views of people with MS. The psychometric properties of the MS Symptom and Impact Diary (MSSID) were evaluated in a sample of 77 people who completed the MSSID daily for 12 weeks. Internal and test–retest reliability, discriminant and convergent validity, and responsiveness were assessed using traditional psychometric methods. RESULTS: The MSSID formed three, internally consistent scales that measured mobility, fatigue, and the overall impact of MS. The test–retest reliability of the mobility scale was adequate for individual comparisons (ICC.0.90) and the fatigue and overall impact scales were adequate for group comparisons (ICC.0.70). The MSSID was able to distinguish between clinical groups depending on clinical course, indoor ambulation status, and relapse status. It demonstrated associations with other single point instruments in the expected direction. Compared with single point instruments, its responsiveness was similar or better, especially in detecting short term improvements in functioning. CONCLUSIONS: The MSSID may provide a useful complement to currently available instruments to measure the outcomes of MS within clinical trials. Further research is needed to explore its feasibility in the context of a randomised controlled trial and its utility for clinicians

Exceptional Points of Degeneracy Induced by Linear Time-Periodic Variation

We present a general theory of exceptional points of degeneracy (EPD) in periodically time-variant systems. We show that even a single resonator with a time-periodic component is able to develop EPDs, contrary to parity-time- (PT) symmetric systems that require two coupled resonators. An EPD is a special point in a system parameter space at which two or more eigenmodes coalesce in both their eigenvalues and eigenvectors into a single degenerate eigenmode. We demonstrate the conditions for EPDs to exist when they are directly induced by time-periodic variation of a system without loss and gain elements. We also show that a single resonator system with zero time-average loss-gain exhibits EPDs with purely real resonance frequencies, yet the resonator energy grows algebraically in time since energy is injected into the system from the time-variation mechanism. Although the introduced concept and formalism are general for any time-periodic system, here, we focus on the occurrence of EPDs in a single LC resonator with time-periodic modulation. These findings have significant importance in various electromagnetic and photonic systems and pave the way for many applications, such as sensors, amplifiers, and modulators. We show a potential application of this time-varying EPD as a highly sensitive sensor

Gender discourse, awareness, and alternative responses for men in everyday living

In this paper, the authors use examples from their experiences to explore the nuances and complexities of contemporary gender practices. They draw on discourse and positioning theories to identify the ways in which culturally dominant, and difficult to notice, gender constructions help shape everyday experiences. In addition, the authors share their view that there are benefits in developing skills in noticing contemporary practices made available by dominant gender constructions. Such noticing expands possibilities for ways of responding and relating that might produce outcomes for men and women that fit with their hopes for living

Substance use disorder and posttraumatic stress disorder symptomology on behavioral outcomes among juvenile justice youth

BACKGROUND AND OBJECTIVES: Substance use behaviors have been identified as a risk factor that places juveniles at greater risk for engaging in delinquent behaviors and continual contact with the juvenile justice system. Currently, there is lack of research that explores comorbid factors associated with substance use, such as post-traumatic stress disorder (PTSD) symptoms, that could help identify youth who are at greatest risk. The aim of the present study was to examine if PTSD symptomology moderated the relationship between substance use disorder (SUD) symptoms and externalizing behaviors and commission of a violent crime; hypothesizing that risk would be heightened among youth with elevated SUD and PTSD symptomology compared to those with elevated SUD symptoms but lower PTSD symptoms. METHOD: The study included 194 predominantly male (78.4%), non-White (74.2%) juvenile justice youth between the ages of 9-18 (M = 15.36). Youth provided responses to assess PTSD symptoms, SUD symptoms, and externalizing behaviors. Commission of a violent crime was based on parole officer report. RESULTS: Findings indicated that SUD symptomology was associated with greater externalizing behaviors at high levels of PTSD symptomology. At low levels of PTSD symptomology, SUD symptoms were inversely associated with externalizing behaviors. An interactive relationship was not observed for commission of violent crimes. CONCLUSIONS: Findings suggest that the association between SUD symptoms and externalizing behaviors among juvenile offenders may be best explained by the presence of PTSD symptomology. SCIENTIFIC SIGNIFICANCE: Addressing PTSD rather than SUD symptoms may be a better target for reducing risk for externalizing behaviors among this population of youth (Am J Addict 2019;28:29-35)

Collaborative project delivery models in infrastructure construction

When projects grow into megaprojects, their management becomes more complex due to an increasing number of inter-organisational interfaces within the project organisation. Spurred on by both the growing size of projects but also the adversity and conflict-prone culture characteristic of construction, the infrastructure industry has turned to collaborative project delivery models based on relational governance. However, little is known of this new phenomenon and as literature thus far mainly focused on the procurement phase and governance, researchers have called for further insight into the delivery phase and how projects using collaborative delivery models work in practice. This thesis aims to investigate the application of CPDM in infrastructure delivery projects and analyse changes introduced thereby for project actors. The aim is examined through three research questions: (1) How do social network dynamics explain the implementation of CPDM in the delivery phase of infrastructure projects; (2) How does using a CPDM impact project delivery; and (3) How does using a CPDM influence the interaction between the project network and its institutional environment?Collaborative project delivery models are said to support trust-building, quicker decision-making, information flow and project quality through the interaction of informal relationships and formal contractual frameworks, emphasizing the social dimension of the project organisation. With these aspects in mind, I follow the recent stream of applying social network analysis and network theories to better understand these inter-organisational relations. To create deeper insight into the changing industry, I also study the interaction of the project with its environment through an institutional lens. This thesis builds on a qualitative research design based on four main case studies. The empirical data consists of interviews, observations and document analysis. I have also mapped the social networks in three projects and approach them through a qualitative lens, focusing on the interaction between the project network and its institutional framing.For megaproject research, this thesis adds rich data regarding project delivery and social networks created in large-scale project organisations. The research also identifies mechanics enabling the creation of collaborative organisations, but also the challenges of too well-connected networks. With respect to institutional change and institutional logics, this thesis adds insight and empirical examples of how logics interact and develop within project organisations. The contrasting results from the case studies show how the project network can either enable or constrain the development of new institutions and logics and how the project acts as an arena for change. As for social network theory, this thesis adds insight into the development of networks and the importance of the ties between actors as conduits of flows within the network, both pertaining to resources and change. Through empirical examples of three project networks, this thesis explains how the ‘snapshots’ of project networks have come to be and how they might develop. Finally, for practitioners, this thesis highlights the need for a collaborative mindset from the get-go and the importance of the formal framework as an enabler of informal social ties. For those working in the field of collaborative megaprojects, the findings acknowledge the importance of the project network and social dynamics within the project. It also highlights the necessary changes in roles and behaviours, especially in early project phases, as actors need to align their understanding of the project in unaccustomed ways

If you want to go far, go with others – How using a collaborative project delivery model affects the project network in infrastructure construction projects

The growth of projects has elicited much interest in the last decades, both in academia and amongst practitioners. The increase in scale and complexity has further brought attention to the particulars of interorganisational collaboration: as projects grow, the relevance and impact of interdependencies between participating organisations rise to the surface. No organisation is an island and so a project becomes an archipelago of interconnected networks. Current literature on interorganisational collaboration focuses on contract and procurement, both important aspects of project management. There is, however, less research pertaining to project realisation and how these changes in interorganisational collaboration shape the project process.A field where this change has been especially noticeable is the infrastructure construction industry, where collaborative project management models have been introduced to reduce adversity and improve project outcomes. These new models necessitate a study of changes these new models bring with them to the conventional ways of work within the field, as they call for new processes and roles in the projects, thus changing how the actors engage with the project network. As such models are based on collaboration, the role of social ties within the project become an especially interesting question.In this work, I expand on the theory pertaining to project networks in the empirical setting of infrastructure projects applying a collaborative project management model, with the aim of examining and gaining a deeper understanding of the collaboration between interorganisational project actors in a collaborative project delivery model. The methods used in this thesis are based in the qualitative research tradition and emphasise interviewing and observation. During this work, 44 interviews were completed in a pre-study and two case projects and observation of both project’s shared office space was carried out. I also analysed project documents and analysed the social network between respondents in the case projects.My results show the importance of social relations as enablers of the realisation of expected benefits of collaborative models. They moreover illustrate the changes necessary for the models to be effective, as well as study how the use of such project models affect the actors’ engagement in the project network

Feature extraction techniques for abandoned object classification in video surveillance

We address the problem of abandoned object classification in video surveillance. Our aim is to determine (i) which feature extraction technique proves more useful for accurate object classification in a video surveillance context (scale invariant image transform (SIFT) keypoints vs. geometric primitive features), and (ii) how the resulting features affect classification accuracy and false positive rates for different classification schemes used. Objects are classified into four different categories: bag (s), person (s), trolley (s), and group (s) of people. Our experimental results show that the highest recognition accuracy and the lowest false alarm rate are achieved by building a classifier based on our proposed set of statistics of geometric primitives' features. Moreover, classification performance based on this set of features proves to be more invariant across different learning algorithms. © 2008 IEEE

Data Descriptor: A genome-scale RNAi screen for genetic interactors of the dynein co-factor nud-2 in Caenorhabditis elegans

Cytoplasmic dynein 1 (dynein) is the predominant microtubule minus end-directed motor in animals and participates in a wide range of cellular processes, including membrane trafficking, nuclear migration, and cell division. Dynein's functional diversity depends on co-factors that regulate its subcellular localization, interaction with cargo, and motor activity. The ubiquitous co-factor nuclear distribution gene E (NudE) is implicated in many of dynein's functions, and mutations in NudE cause the brain developmental disease microcephaly. To identify genetic interactors of the Caenorhabditis elegans NudE homolog nud-2, we performed a genome-wide RNAi screen with the null allele nud-2(ok949), which compromises dynein function but leaves animals viable and fertile. Using bacterial feeding to deliver dsRNAs in a 96-well liquid format and a semi-automated fluorescence microscopy approach for counting parents and progeny, we screened 19762 bacterial clones and identified 38 genes whose inhibition caused enhanced lethality in nud-2(ok949) relative to the nud-2(+) control. Further study of these genes, many of which participate in cell division, promises to provide insight into the function and regulation of dynein.The authors acknowledge the support of the BioSciences Screening i3S Scientific Platform. Funding for this project was provided by the European Research Council under the European Union's Seventh Framework Programme (ERC grant agreement n o ERC-2013-StG-338410-DYNEINOME to R.G.), by the European Molecular Biology Organization (EMBO Installation Grant 2545 to R.G.), by the Fundacao para a Ciencia e a Tecnologia (IF/01015/2013/CP1157/CT0006 to R.G. and SFRH/BD/103495/2014 to H. R.), and by 'Norte-01-0145-FEDER-000029-Advancing cancer research: from basic knowledge to application', supported by the Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement through the European Regional Development Fund (FEDER