Phase diagram of turbulence in superfluid 3He-B

In superfluid 3He-B mutual-friction damping of vortex-line motion decreases roughly exponentially with temperature. We record as a function of temperature and pressure the transition from regular vortex motion at high temperatures to turbulence at low temperatures. The measurements are performed with non-invasive NMR techniques, by injecting vortex loops into a long column in vortex-free rotation. The results display the phase diagram of turbulence at high flow velocities where the transition from regular to turbulent dynamics is velocity independent. At the three measured pressures 10.2, 29.0, and 34 bar, the transition is centered at 0.52--0.59Tc and has a narrow width of 0.06Tc while at zero pressure turbulence is not observed above 0.45Tc.Comment: To be published in J. Low Temp. Phys. (QFS2004 proceedings

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention