Denosumab Experience in a Patient with End-Stage Renal Disease and Paget’s Disease of the Bone

Paget’s disease of the bone (PDB) is a chronic bone disease which is characterized by accelerated bone turnover and disorganized bone remodeling. Diagnosis and treatment of PDB is particularly challenging in patients with chronic kidney disease (CKD). Denosumab administered subcutaneously at a single dose of 60 mg every 3 months reduced both serum total and bone-specific alkaline phosphatase (ALP) levels to near normal range in a 47-year-old male with CKD was suspected of having PDB due to very high serum total ALP levels and imaging findings suggestive of poliostotic involvement. Elevated serum total ALP levels detected at 3 months after denosumab suggests that serum total ALP starts to increase after 60 days of treatment but it is difficult to exactly determine the day when serum total ALP started to increase. It seems wise to administer denosumab at an interval of 60-120 days to maintain serum total ALP level within normal limits

A case with Parkinsonism secondary to bilateral subdural hematoma

Subdural hematoma is a rare cause of secondary Parkinsonism. In this study, we presented a case of Parkinsonian syndrome caused by a bilateral subdural hematoma. The patient’s Parkinsonism completely healed following successful surgical removal of the hematomas without any anti-parkinson drug

Çoklu Zekâ Kuramı Tabanlı Etkin Öğrenme Yaklaşımının Öğrenci Başarısına Ve Tutumuna Etkisi

The purpose of this study is to determine the effect of an active learning approach based on multiple intelligence theory on students' science achivement and science attitudes in first year elementary school pupils. An experimental method was used in this research. The research was carried out on two groups; the experimental group (n=36) and a control group (n=36) The data were obtained by administering the Science Achievement Test, an Attitude Scale, Questionnaires, the Students' Files and Expression with Picture & Writing Test and by using an Observation Record Form. The findings demonstrated that, in regard to the students' science achievement and science attitudes, there were significant differences among the groups in favour of the experimental group.Araştırmanın temel amacı, ilköğretim birinci sınıf düzeyinde çoklu zekâ kuramı tabanlı etkin öğrenme yaklaşımının öğrencilerin fen başarısına ve tutumuna etkisini belirlemektir. Çalışmada deneysel yöntem kullanılmıştır. Araştırma deney (n=36) ve kontrol (n=36) grubu olmak üzere iki grup üzerinde yürütülmüştür. Araştırmanın verileri Fen Başarı Testi, Tutum Ölçeği, Anketler, Öğrenci Dosyaları ve Gözlem Kayıt Formları kullanılarak elde edilmiştir. Bulgular, öğrenci tutumları ve fen başarısı açısından gruplar arasında deney grubu lehine anlamlı farklar olduğunu ortaya koymuştur

Gelirin Optimal Vergilendirilmesi: Teori ve Politika

Optimal vergi politikasında gelirin düz oranlı vergilendirilmesi, yüksek gelire sıfır marjinal vergi oranı uygulanması ve vergilendirmenin dolaylı vergilere kaydırılması gibi üç eğilim gözlenmektedir. Bu eğilimlere paralel olarak, optimal vergiden optimal vergi politikasına doğru bir kayma söz konusudur ve son dönemde optimal vergi oranları tartışılmaktadır. 1980 sonrasında, OECD ülkeleri gelir vergisi dilimlerini azaltmış, marjinal gelir vergisi oranlarında indirime gitmiş ve vergiyi tabana yaymışlardır. Türkiye'de de benzer eğilimler görülmekle birlikte vergilendirme ücretlilerden kesilen gelir vergisi ve dolaylı vergilere kaymaktadır. Vergi tarifesinin üst dilimine sıfır marjinal vergi oranı uygulanması ve alt gelir grupları için negatif gelir vergisinin dikkate alınması düşük ve yüksek ücretlerde adalet ve etkinlik dengesini sağlarken orta gelir grupları ihmal edilmektedir. Bundan dolayı, özellikle, orta gelir grubundaki evli ve çocuklu ailelere yönelik vergi ve sosyal transferlerle dolaylı vergilerin adalet açısından gözden geçirilmesi gerekmektedir

A mobile ammunition distribution system design on the battlefield

Ankara : The Department of Industrial Engineering and the Institute of Engineering and Science of Bilkent University, 2010.Thesis (Ph.D.) -- Bilkent University, 2010.Includes bibliographical references leaves 150-158.Ammunition has been the most prominent factor in determining the outcome of combat. In this dissertation we study a military logistics problem in which ammunition requirements of the combat units, which are located on the battle- field, are to be satisfied in the right amount when and where they are needed. Our main objective is to provide a decision support tool that can help plan ammunition distribution on the battlefield. We demonstrate through an extensive literature review that the existing models are not capable of handling the specifics of our problem. Hence, we propose a mathematical programming model considering arc-based product-flow with O(n 4 ) decision variables and constraints. The model is a three-layer commodity-flow location routing formulation that distributes multiple products, respects hard time windows, allows demand points to be supplied by more than one vehicle or depot, and locates facilities at two different layers. We then develop a new mathematical programming model with only O(n 3 ) decision variables and constraints by considering node-based product-flow. We derive several valid inequalities to speed up the solution time of our models, illustrate the performance of the models in several realistically sized scenarios, and report encouraging results. Based on these mathematical models we propose two three-phase heuristic methods: a routing-first location-second and a location- first routing-second heuristic. The computational results show that complex real world problems can effectively be solved in reasonable times with the proposed heuristics. Finally, we introduce a dynamic model that designs the distribution system in consecutive time periods for the entire combat duration, and show how the static model can be utilized in dynamic environments.Toyoğlu, HünkarPh.D

STUDENTS’ OPINIONS ABOUT SCIENCE AND TECHNOLOGY IN TURKEY AND THE UNITED STATES: A CROSS-CULTURAL STUDY

The aim of this study is to determine the thoughts of Turkish and American middle school students on science and technology. One intact school was assigned randomly for this study from both countries. The sampling of the study contains 479 students (363 Turkish students, 116 American students) from two countries aged between 11 and 13. The data for the study were obtained by using ROSE Survey. The results of the study revealed similarities and dissimilarities on science and technology between the students of the two countries. The findings of the study are thought to improve the education of universal science and technology and to contribute to the researchers doing research on comparative education and cultural diversity and to the literature of international science education.Keywords: curriculum and instruction, science education, middle school

Fatty Acid Profiles of Fish Oil Derived by Different Techniques from By-products of Cultured Black Sea Salmon, Oncorhynchus mykiss

The fatty acid profiles of fish oil extracted from by-products of cultured Black Sea salmon, Oncorhynchus mykiss, using conventional (CFO) and dry freezing oil (DFO) techniques were investigated. In the CFO and DFO groups, MUFA+PUFA comprised 74.00% and 72.68% of total fatty acids, respectively. The highest PUFA was linoleic acid (CFO = 14.22%, DFO = 13.15%). Docosahexaenoic acid (DHA, C22:6n3) was the second most concentrated fatty acid for PUFA in the CFO (8.12%) and DFO (8.02%) groups, followed by eicosapentaenoic acid (EPA, C20:5n3) (CFO = 4.39%, DFO = 2.87%). Similarly, the difference between groups in omega-3 was statistically significant (P<0.05) and the CFO ratio was higher in the DFO. The PI, AI, TI, h/H, and UI percentages in the CFO group were 0.99, 0.37, 0.26, 2.98, and 1.73, respectively, while in the DFO group they were 0.80, 0.35, 0.31, 2.83, and 1.61, respectively. It was concluded that the oils obtained from Black Sea salmon by-products were rich in omega-3 fatty acids and had good lipid quality indexes

İsveç ve Türkiye’de erken çocukluk dönemi eğitim politikalarının eğitim programlarına yansımaları

The purpose of the study is to investigate the reflections of early childhood education (ECE) policies on the curricula in Sweden and Turkey. In this study holistic multiple case design was conducted using data collected from documents. The primary documents reviewed for the study are ECE curricula and policy documents on the official websites of Sweden and Turkey. Secondary documents reviewed are UNESCO, OECD, Eurydice reports and international publications. The findings of the study indicated that in Sweden and Turkey ECE policies were mainly based different aims. The social and economic arguments of these aforementioned policies in Turkey were not clarified as satisfactorily as in Sweden. The policy differences between these two countries have been influential in the historical development of the curricula and structures. The goals/objectives of the curricula are influenced by countries’ own socio-political contexts and the policy tools which promote developmental processes of the curricula varied across countries.Bu araştırma İsveç ve Türkiye’de erken çocukluk dönemi (EÇD) eğitim politikalarının eğitim programlarına yansımalarının incelenmesi amacıyla yürütülmüştür. Nitel araştırma desenlerinden bütüncül çoklu durum desenine uygun olarak yürütülen çalışmanın verileri doküman inceleme yöntemiyle elde edilmiştir. Araştırmanın birincil kaynaklarını her iki ülkenin EÇD hizmetlerinin yürütülmesinden sorumlu bakanlıkları ile diğer resmi internet adreslerinde yer alan EÇD eğitim programları ve politika belgeleri oluşturmuştur. Araştırma konusu ile ilgili olan UNESCO, OECD, Eurydice raporları ve kitap, makale vb. belgeler ise araştırmanın ikincil kaynakları arasında yer almıştır. Elde edilen bulgular doğrultusunda İsveç ve Türkiye’de EÇD politikalarının geliştirilmesinde temele alınan amaçların birbirinden farklı olduğu ve Türkiye’de geliştirilen politikaların; toplumsal ve ekonomik temellerinin İsveç’teki kadar güçlü bir şekilde ifade edilemediği sonucuna ulaşılmıştır. Ayrıca ülkeler arasındaki politika farklılıklarının programların tarihi gelişiminde ve programların yapısında etkili olduğu, her iki ülkede programların genel ve özel hedeflerinin ülkelerin sosyo-politik bağlamlarından etkilendiği ve eğitim programlarının geliştirilmesini sağlayan politika araçlarının genellikle birbirinden farklı olduğu görülmüştür