Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging

Silicon nanoparticles are experimentally investigated as a potential hyperpolarized, targetable MRI imaging agent. Nuclear T_1 times at room temperature for a variety of Si nanoparticles are found to be remarkably long (10^2 to 10^4 s) - roughly consistent with predictions of a core-shell diffusion model - allowing them to be transported, administered and imaged on practical time scales without significant loss of polarization. We also report surface functionalization of Si nanoparticles, comparable to approaches used in other biologically targeted nanoparticle systems.Comment: supporting material here: http://marcuslab.harvard.edu/Aptekar_hyper1_sup.pd

Mathematical Methods in Medical Imaging: Analysis of Vascular Structures for Liver Surgery Planning

this paper is to discuss digital image processing methods to analyze the patient's intrahepatic vessel structure and to determine the individual localization and extension of the liver segments from clinical CT or MR volume data. Such a volume is denoted by a matrix

Feasibility study of the polychromatic laser guide star

International audienceWe briefly recall the principle of the polychromatic laser guide star, which aims at providing measurements of the tilt of incoming wavefronts with a 100% sky coverage, We describe the main results of the feasibility study of this concept undertaken within the ELP-OA porgramme. We finally summarize our plans for a full demonstrator at Observatoire de Haute-Provence