Childhood asthma and reduced lung function : What comes first?

The associations between early life lung function and obstructive airway disease and lung function development through childhood are still unsettled. The main aim of the thesis was to determine the overall association between lung function and asthma through childhood and it is based upon data from the prospective birth cohort study “the Environment and Childhood Asthma Study” including lung function measurement at birth and follow up until 10 years of age. Children with reduced lung function at birth measured by tidal flow volume loops or passive respiratory mechanics had a doubling risk of asthma at ten years of age. Children who had reduced lung function measured by both methods represented a high risk group with a four doubling risk of asthma. Among the 10 years old children a lifetime prevalence of asthma of 20% and current asthma in 11% was found. Lung function through childhood was highly associated with lung function at birth and found to be independent of atopic disease and lower respiratory tract infections the first two years of life. In contrast to the previous belief that it is the first two years of life that are the most vulnerable in the development of the lungs, the results of the thesis point to pre natal factors as decisive for later obstructive airway disease and lung function development

Dagens Næringsliv: Fra skipsfartsorgan til næringslivsavis − søkelys på en redaksjonell snuoperasjon

Hva skjer når en skipsfartsavis har problemer, når næringen den har som formål å dekke strever i motvind mens andre deler av næringslivet blomstrer? Artikkelen ser nærmere på hvordan'Sjøfarten' ble født på ny. Den belyser utviklingen i det redaksjonelle produktet Dagens Næringsliv fra slutten av 70-tallet og frem til i dag

Helicobacter pylori in early childhood and asthma in adolescence

Objective An inverse effect of Helicobacter pylori (H. pylori) on the occurrence of asthma is debated and early acquisition of H. pylori may be important. We analyzed sera from 197 children from Environment and Childhood Asthma (ECA) study in Oslo for Helicobacter pylori (H. pylori) at 2 and 10 years, and symptoms and signs of asthma at 16 years of age. Results While 16.4% of children who were H. pylori negative at 2 and 10 years had current asthma at 16 years, none of the 12 children who were H. pylori positive at 2 years of age had asthma at the age of 16 years, regardless of H. pylori status at 10 years. This trend for less current asthma in children who were H. pylori positive at 2 years compared to persistent or transient negative status at 10 years was not statistically significant, probably due to low number of H. pylori positive children at 2 years of age. Acquisition of H. pylori in school age did not appear to influence the risk of current asthma. Much larger prospective studies are probably required to document whether or not early H. pylori infection may be involved in the risk of asthma development in later childhood

Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial

acceptedVersio