Author Correction:Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article

“Man får nog vara kunnig själv” : En kvalitativ studie om lärarstudenters synsätt på skolbiblioteket i sitt kommande yrke.

The central theme of this study is the school library and how teacher students' view the integration of the library in teaching. Previous research has shown that the teacher programs lack education and knowledge on how to practically make us of the library. The purpose of this study is to investigate what perceptions and experiences future teachers have about the library's function and how they view the integration of the library in their teaching after graduation. To investigate the teacher students' perceptions and experiences, a qualitative analysis was made using semi-structured interviews at one university in Sweden including five primary school teachers and five subject teachers. This study is based on Loertscher's Teacher Taxonomy. One conclusion drawn was that the parents' approach to the library is more decisive than the informants' experiences from their schooling. The teacher students with parents that would read and often bring them to the library are more likely to make use of the library themselves in their future profession. The results show that most teacher students will use the library mainly in the Swedish subject. Furthermore, the results also concluded that the subject teachers in the study more frequently would use the library as a second classroom, a place for the pupil to study individually, or a place for having meetings. Many of the teacher students have good opportunities for future collaboration with the library, what tends to affect the usage is ignorance, the workplace, and the teacher students' previous experiences

“Man får nog vara kunnig själv” : En kvalitativ studie om lärarstudenters synsätt på skolbiblioteket i sitt kommande yrke.

The central theme of this study is the school library and how teacher students' view the integration of the library in teaching. Previous research has shown that the teacher programs lack education and knowledge on how to practically make us of the library. The purpose of this study is to investigate what perceptions and experiences future teachers have about the library's function and how they view the integration of the library in their teaching after graduation. To investigate the teacher students' perceptions and experiences, a qualitative analysis was made using semi-structured interviews at one university in Sweden including five primary school teachers and five subject teachers. This study is based on Loertscher's Teacher Taxonomy. One conclusion drawn was that the parents' approach to the library is more decisive than the informants' experiences from their schooling. The teacher students with parents that would read and often bring them to the library are more likely to make use of the library themselves in their future profession. The results show that most teacher students will use the library mainly in the Swedish subject. Furthermore, the results also concluded that the subject teachers in the study more frequently would use the library as a second classroom, a place for the pupil to study individually, or a place for having meetings. Many of the teacher students have good opportunities for future collaboration with the library, what tends to affect the usage is ignorance, the workplace, and the teacher students' previous experiences

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function

Sex-specific cardiovascular comorbidities with associations in dermatologic and rheumatic disorders

Cardiology, dermatology, and rheumatology form a fascinating triad. Many skin and joint disorders are associated with cardiovascular comorbidities because they share etiologic elements. Female predominance is often remarkable and likely related to autoimmune pathology. Although studies have shown that X-encoded genes may be involved in the differences in immunity between males and females, other studies have also shown that sex chromosomes are irrelevant and that estrogens and androgens are responsible for the differences. The elevated immune activity in females provides a beneficial position in coping with a pathogenic stimulus but may also enhance their susceptibility to autoimmunity. The complexity of the immune system and its role as a defensive force against infection requires an armamentarium to precisely identify and selectively control inflammatory processes or cells which promote atherosclerosis. On the other hand, the inflammation in skin diseases seems to be an active source of diverse proinflammatory cytokines and chemokines which can predispose to cardiovascular comorbidities. Also, it has been shown that comorbidity disproportionately accelerates risk in women. The skin offers a readily available window to facilitate detection of risk factors or even to assist the diagnostic process regarding a variety of disorders, including those with cardiovascular involvement. Current imaging techniques provide exquisite capabilities for diagnosing and possibly even counteracting atherosclerotic plaque formation, before serious cardiovascular events occur. Combining imaging approaches (such as videocapillaroscopy, intravascular ultrasound, and FDG positron emission tomography) with insights based on immunology will likely accelerate advances in this area. We review major dermatologic manifestations and rheumatologic disorders which are associated with cardiac and vascular abnormalities. In particular we discuss sex-specific aspects concerning incidence and severity of cardiovascular disease associated with systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, atopic dermatitis, and hidradenitis suppurativa

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P &amp;lt; 5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function