33 research outputs found
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
- Aasvang GM
- Abajobir AA
- Abate KH
- Abbafati C
- Abbas KM
- Abd-Allah F
- Abdulle AM
- Abera SF
- Abraham B
- Abu-Raddad LJ
- Abyu GY
- Adebiyi AO
- Adedeji IA
- Ademi Z
- Adou AK
- Adsuar JC
- Afshin A
- Agardh EE
- Agarwal A
- Agrawal A
- Ajala ON
- Akinyemiju TF
- Al-Aly Z
- Alam K
- Alam NKM
- Aldhahri SF
- Aldridge RW
- Alemu ZA
- Alexander LT
- Ali R
- Alkerwi A
- Alla F
- Allebeck P
- Alsharif U
- Altirkawi KA
- Alvarez Martin E
- Alves Silveira DG
- Alvis-Guzman N
- Amare AT
- Amberbir A
- Amegah AK
- Amini H
- Ammar W
- Amrock SM
- Andersen HH
- Anderson BO
- Anderson HR
- Antonio CAT
- Anwar P
- Aquino Faraon EJ
- Arnlov J
- Artaman A
- Asayesh H
- Asghar RJ
- Assadi R
- Atique S
- Avokpaho EFGA
- Awasthi A
- Azzopardi P
- Bacha U
- Badawi A
- Baernighausen T
- Bahit MC
- Balakrishnan K
- Bans C
- Barac A
- Barber RM
- Barker-Collo SL
- Barquera S
- Barregard L
- Barrero LH
- Basu S
- Bazargan-Hejazi S
- Beardsley J
- Beatriz Heredia-Pi I
- Beatriz Lawrynowicz AE
- Bedi N
- Beghi E
- Bell ML
- Bello AK
- Bennett DA
- Bensenor IM
- Berhane A
- Bernabe E
- Betsu BD
- Beyene AS
- Bhala N
- Bhansali A
- Bhatt S
- Bhutta ZA
- Biadgilign S
- Bicer BK
- Bikbov B
- Biryukov S
- Bisanzio D
- Bjertness E
- Blore JD
- Borschmann R
- Boufous S
- Bourne RRA
- Brainin M
- Brauer M
- Brazinova A
- Breitborde NJK
- Brenner H
- Broday DM
- Brugha TS
- Brunekreef B
- Burnett R
- Butt ZA
- Cahill LE
- Caicedo AJP
- Calabria B
- Cardenas R
- Carmen Gomez-Cabrera M
- Carpenter D
- Casey DC
- Castaneda-Oquela CA
- Castillo Rivas J
- Catala-Lopez F
- Cercy K
- Chang J-C
- Charlson FJ
- Chiang PP-C
- Chibalabala M
- Chimed-Ochir O
- Chisumpa VH
- Chitheer AA
- Choi J-YJ
- Christensen H
- Christopher DJ
- Ciobanu LG
- Coates MM
- Cohen AJ
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- Cooper LT
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- Cornaby L
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- Crump JA
- Cuevas-Nasu L
- Damasceno A
- Dandona L
- Dandona R
- Darby SC
- Dargan PI
- das Neves J
- Davis AC
- Davletov K
- De la Cruz-Gongora V
- De Leo D
- Defo BK
- Degenhardt L
- Del Gobbo LC
- del Pozo-Cruz B
- Dellavalle RP
- Deribew A
- Des Jarlais DC
- Dharmaratne SD
- Dhillon PK
- Diaz-Tome C
- Dicker D
- Dimbuene ZT
- Ding EL
- Dolores Sanchez-Nino M
- Dorsey ER
- Doyle KE
- Driscoll TR
- Duan L
- Dubey M
- Duncan BB
- Elyazar I
- Endries AY
- Ermakov SP
- Erskine HE
- Eshrati B
- Estanislao Castro R
- Esteghamati A
- Estep K
- Factors GBDR
- Fahimi S
- Farid TA
- Faro A
- Farvid MS
- Farzadfar F
- Feigin VL
- Fereshtehnejad S-M
- Fernandes JG
- Ferrari AJ
- Filipa de Castro E
- Fischer F
- Fitchett JRA
- Fleming T
- Foigt N
- Foreman K
- Forouzanfar MH
- Fowkes FGR
- Francisco Hernandez-Llanes N
- Franklin RC
- Frostad JJ
- Fuerst T
- Fullman N
- Futran ND
- Gakidou E
- Garcia-Basteiro AL
- Gebrehiwot TT
- Gebremedhin AT
- Geleijnse JM
- Gessner BD
- Gething PW
- Giref AZ
- Giroud M
- Gishu MD
- Godwin WW
- Goenka S
- Gomez-Dantes H
- Gona P
- Goodridge A
- Gopalani SV
- Gotay CC
- Goto A
- Gouda HN
- Griswold M
- Gugnani HC
- Guillemin F
- Guo Y
- Gupta R
- Gupta R
- Gutierrez RA
- Haagsma JA
- Hafezi-Nejad N
- Haile D
- Hailu GB
- Halasa YA
- Hamadeh RR
- Hamidi S
- Handal AJ
- Hankey GJ
- Hao Y
- Harb HL
- Harikrishnan S
- Hassanvand MS
- Hassen TA
- Havmoeller R
- Heydarpour P
- Hoek HW
- Hoffman HJ
- Horino M
- Horita N
- Hosgood HD
- Hoy DG
- Hsairi M
- Htet AS
- Hu G
- Huang JJ
- Husseini A
- Hutchings SJ
- Huybrechts I
- Iburg KM
- Idrisov BT
- Ileanu BV
- Inoue M
- Jacobs TA
- Jacobsen KH
- Jahanmehr N
- Jakovljevic MB
- Jansen HAFM
- Jassal SK
- Javanbakht M
- Jayatilleke AU
- Jee SH
- Jeemon P
- Jha V
- Jiang Y
- Jibat T
- Jin Y
- Johnson CO
- Jonas JB
- Kabir Z
- Kalkonde Y
- Kamal R
- Kan H
- Karch A
- Karema CK
- Karimkhani C
- Kasaeian A
- Kaul A
- Kawakami N
- Kazi DS
- Keiyoro PN
- Kemp AH
- Kengne AP
- Keren A
- Kesavachandran CN
- Khader YS
- Khan AR
- Khan EA
- Khan G
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- Khatibzadeh S
- Khera S
- Khoja TAM
- Khubchandani J
- Kiadaliri AA
- Kieling C
- Kim C-I
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- Knibbs LD
- Kokubo Y
- Kopec JA
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- Koyanagi A
- Kravchenko M
- Kromhout H
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- Kuipers EJ
- Kumar GA
- Kwan GF
- Kyu HH
- Lal DK
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- Lan Q
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- Larsson A
- Latif AA
- Leasher JL
- Leigh J
- Leung J
- Levi M
- Levy TS
- Li X
- Li Y
- Liang J
- Liang X
- Lim SS
- Liu PY
- Liu S
- Lloyd BK
- Logroscino G
- Lopez AD
- Lotufo PA
- Lozano R
- Lunevicius R
- Maclntyre M
- Mahdavi M
- Mahesh PA
- Majdan M
- Majeed A
- Malekzadeh R
- Malta DC
- Manamo WAA
- Mapoma CC
- Marcenes W
- Marczak L
- Maria Haro J
- Martin RV
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- Masiye F
- Matsushita K
- Matzopoulos R
- Mayosi BM
- McGrath JJ
- McKee M
- Meaney PA
- Medina C
- Mehari A
- Mekonnen AB
- Melaku YA
- Memish ZA
- Mena-Rodriguez F
- Mendoza W
- Mensah GA
- Mensink GBM
- Meretoja A
- Meretoja TJ
- Mesfin YM
- Mhimbira FA
- Miller TR
- Mills EJ
- Mirarefin M
- Misganaw A
- Mock CN
- Mohammadi A
- Mohammed S
- Mokdad AH
- Mola GLD
- Monasta L
- Montanez Hernandez JC
- Montico M
- Moradi-Lakeh M
- Morawska L
- Mori R
- Mozaffarian D
- Mueller UO
- Mullany E
- Mumford JE
- Murray CJL
- Murthy GVS
- Nachega JB
- Naghavi M
- Naheed A
- Nangia V
- Nassiri N
- Neal B
- Newton JN
- Ng M
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- Nisar MI
- Norheim OF
- Norman RE
- Norrving B
- Nyakarahuka L
- Obermeyer CM
- Ogbo FA
- Oh I-H
- Oladimeji O
- Olivares PR
- Olsen H
- Olusanya BO
- Olusanya JO
- Opio JN
- Oren E
- Orozco R
- Ortiz A
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- Pana A
- Park E-K
- Parry CD
- Parsaeian M
- Patel T
- Patil ST
- Patten SB
- Patton GC
- Pearce N
- Pereira DM
- Perico N
- Pesudovs K
- Pete PMN
- Petzold M
- Phillips MR
- Piel FB
- Pillay JD
- Plass D
- Polinder S
- Pond CD
- Pope CA
- Pope D
- Popova S
- Poulton RG
- Pourmalek F
- Prasad NM
- Qorbani M
- Quintanilla BPA
- Rabiee RHS
- Radfar A
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- Rahimi-Movaghar V
- Rahman M
- Rahman MHU
- Rahman SU
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- Refaat AH
- Rehm CD
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- Ricardo Campos-Nonato I
- Rivera JA
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- Santomauro DF
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- Sartorius B
- Satpathy M
- Savic M
- Sawhney M
- Schmidhuber J
- Schmidt MI
- Schneider IJC
- Schoettker B
- Schutte AE
- Schwebel DC
- Scott JG
- Seedat S
- Sepanlou SG
- Servan-Mori EE
- Shaheen A
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- Sigfusdottir ID
- Silva DAS
- Silverberg JI
- Simard EP
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- Singh A
- Singh JA
- Singh PK
- Slepak EL
- Sofia E Sa Farinha C
- Soljak M
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- Sorensen RJD
- Sposato LA
- Sreeramareddy CT
- Stathopoulou V
- Steckling N
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- Stein DJ
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- Sunguya BF
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- Szoeke CEI
- Tabares-Seisdedos R
- Takahashi K
- Talongwa RT
- Tanne D
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- Taylor HR
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- Tegegne TK
- Tekle DY
- Terkawi AS
- Thakur JS
- Thomas BA
- Thomas ML
- Thomson AJ
- Thorne-Lyman AL
- Thrift AG
- Thurston GD
- Tillmann T
- Tobe-Gai R
- Tobollik M
- Topor-Madry R
- Topouzis F
- Towbin JA
- Tran BX
- Tsilimparis N
- Tura AK
- Tuzcu EM
- Tyrovolas S
- Ukwaja KN
- Undurraga EA
- Uneke CJ
- Uthman OA
- van Donkelaar A
- van Os J
- Varakin YY
- Vasankari T
- Veerman JL
- Venketasubramanian N
- Violante FS
- Vollset SE
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- Wagner JA
- Waller SG
- Wang H
- Wang J
- Wang L
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- Weichenthal S
- Weiderpass E
- Weintraub RG
- Werdecker A
- Westerman R
- Whiteford HA
- Wijeratne T
- Wiysonge CS
- Wolfe CDA
- Won S
- Woolf AD
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- Xavier D
- Xu G
- Yadav AK
- Yakob B
- Yalew AZ
- Yano Y
- Yaseri M
- Ye P
- Yip P
- Yonemoto N
- Yoon S-J
- Younis MZ
- Yu C
- Zaidi Z
- Zaki MES
- Zhao Y
- Zhou M
- Zhu J
- Zipkin B
- Zodpey S
- Zuhlke LJ
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation
Humoral and cellular responses to a non-adjuvanted monovalent H1N1 pandemic influenza vaccine in hospital employees
- Author
- AC Boon
- AM Iorio
- BC Schanen
- Carmen Sarabia
- Claudia Carranza
- D Van der Vliet
- E Plennevaux
- Eduardo Sada
- Esmeralda Juárez
- F Roman
- Fernando Hernández-Sánchez
- G Chowell
- GM Air
- GM Li
- H Lagler
- H Singh
- I Stephenson
- J Wu
- JA Greenbaum
- K Scheible
- LE Brown
- LE Wagar
- Lourdes Garcia-Garcia
- Ma Eugenia Manjarrez
- Ma Teresa Herrera
- Marcela Muñoz-Torrico
- Martha Torres
- ME Greenberg
- PG Thomas
- R Falfan-Valencia
- RH Randles
- Silvia Guzman-Beltran
- SK Schwander
- T Nolan
- TM Strutt
- VR Duvvuri
- W Phongsamart
- W Tu
- WHO
- X Ge
- Y Zhou
- YD Mahnke
- Yolanda Gonzalez
- YS Choi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis
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- Zaoui P.
- Zateyshchikova A.
- Zateyshshikov D.
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- Zsom M.
- Zub L.
- Zykova T.
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
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- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
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- Bartos I.
- Basak Soummyadip
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- Bassiri Riccardo
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- Bergamin Fabio
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- Bertolini A.
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- Bhaumik Shubhagata
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- Bolingbroke Georgia
- Bolliand A.
- Bondarescu Ruxandra
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- Brillet A.
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- CHAKRABORTY PRATIK.
- Chalathadka Subrahmanya Shreevathsa
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- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
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- CHASSANDE-MOTTIN Eric
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
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- Chen A.
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- CHIOFALO MARIA. LUISA.
- Chiummo Antonino
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- Christensen Nelson
- Chua Sheon S. Y.
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- Chung K. W.
- Ciani Giacomo
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- Concetta Tringali Maria
- Conti Livia
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- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
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- Corsi Alessandra
- Cortese Stefano
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- Cowart M. J.
- Coyne Dennis
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- Craig K.
- Creed R.
- Creighton Jolien
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- Cremonese Paolo
- Criswell Alexander
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- Croquette Michaël
- Crouch R.
- Crowder S. G.
- Cudell Jean-René
- Cullen T. J.
- Cumming Alan
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- Cusinato Marco
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- D'Angelo Beatrice
- D'Antonio S.
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- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
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- Zeoli M.
- Zerrad M.
- Zevin Michael
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- Zhang Rui
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- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Arnaud Nicolas
- Arogeti M.
- Aronson S. M.
- Arène M.
- Asada Hideki
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae S.
- Bae Y.
- Bagnasco Stefano
- Bai Y.
- Baier J. G.
- Baird J.
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
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- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
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- Chen ChianShu
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- error error
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- Estevez Dimitri
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- Ferrante Isidoro
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- Figura Przemysław
- Fiori Alessio
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- Fishbach Maya
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- GIORGIO CINZIA. DI.
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- Watada K.
- Watarai D.
- Watchi Jennifer
- Wayt K. E.
- Weaver B.
- Weaving C. R.
- Webster S. A.
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- Wu H.
- Wysocki Daniel
- Xiao Liting
- Yadav N.
- Yamada T.
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto Takahiro
- Yamashita K.
- Yamazaki R.
- Yang Fengwei
- Yang Kate Z.
- Yang Le
- Yang Y. -C.
- Yang Yang
- Yang Yi
- Yap M. J.
- Yeeles D. W.
- Yeh S. -W.
- Yelikar A. B.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yoshioka T.
- Yu Hang
- Yu Haocun
- Yuzurihara H.
- Zadrożny A.
- Zahoor Jan Aasim
- Zanolin M.
- Zeidler Simon
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhan M.
- Zhang H.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Y.
- Zhao C.
- Zhao G.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
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- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
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- Yamamura S.
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- Yan S.
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- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- Zadrożny A.
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- Zeeshan M.
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barber J.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Bell Angus
- Benedetto V.
- Beniwal D.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
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- Yu Hang
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- Zimmerman Aaron
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- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
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- Tsujikawa Takahiro
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- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Topology, assembly, and electronics: three pillars for designing supramolecular polymers with emergent optoelectronic behavior
- Publication venue
- Publication date
- 01/01/2015
- Field of study
“Emergence-upon-assembly” – where unique properties arise following the formation of hierarchical superstructures – is a common strategy employed by biology to produce materials that possess advanced optical and electronic properties. Supramolecular polymers are periodic macromolecules, whose monomers are held together by noncovalent bonding, and they display emergence-upon-assembly when sufficient consideration is given to topology, assembly, and orbital interactions. Herein we discuss the criteria to consider when designing supramolecular polymers with emergent optoelectronic properties by placing particular emphasis on the contributions of topology, assembly mechanism, and intramolecular electronic communication in donor–acceptor systems
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Cooperatively Assembling Donor–Acceptor Superstructures Direct Energy Into an Emergent Charge Separated State
- Publication venue
- Publication date
- 04/06/2014
- Field of study