448 research outputs found
Extension of SEA model to subsystems with non-uniform modal energy distribution
International audienceIn order to enlarge the application field of Statistical Energy Analysis (SEA), a reformulation is proposed. The model described here, Statistical modal Energy distribution Analysis (SmEdA), does not assume equipartition of modal energies contrary to classical SEA. Theoretical derivations are based on dual modal formulation described in [1,2] for the general case of coupled continuous elastic systems. Basic SEA relations describing power flow exchanged by two oscillators are used to obtain modal energy equations. They permit to determine modal energies of coupled subsystems from the knowledge of modes of uncoupled subsystems. The link between SEA and SmEdA is established and render possible to mix the two approaches: SmEdA for subsystems where equipartition is not verified and SEA for other subsystems. Three typical configurations of structural couplings are described for which SmEdA improves energy prediction compared to SEA: (a) coupling of subsystems with low modal overlap. (b) coupling of heterogeneous subsystems. (c) case of localised excitations. The application of the proposed method is not limited to academic structures, but could easily be applied to complex structures by using finite element method (FEM). In this case, FEM are used to calculate the modes of each uncoupled subsystems; these data are then used in a second step to determine modal coupling factors necessary to SmEdA to modelise the coupling
Detection of confinement and jumps in single molecule membrane trajectories
We propose a novel variant of the algorithm by Simson et al. [R. Simson, E.D.
Sheets, K. Jacobson, Biophys. J. 69, 989 (1995)]. Their algorithm was developed
to detect transient confinement zones in experimental single particle tracking
trajectories of diffusing membrane proteins or lipids. We show that our
algorithm is able to detect confinement in a wider class of confining potential
shapes than Simson et al.'s one. Furthermore it enables to detect not only
temporary confinement but also jumps between confinement zones. Jumps are
predicted by membrane skeleton fence and picket models. In the case of
experimental trajectories of -opioid receptors, which belong to the family
of G-protein-coupled receptors involved in a signal transduction pathway, this
algorithm confirms that confinement cannot be explained solely by rigid fences.Comment: 4 pages, 3 figure
Resonance modes in a 1D medium with two purely resistive boundaries: calculation methods, orthogonality and completeness
Studying the problem of wave propagation in media with resistive boundaries
can be made by searching for "resonance modes" or free oscillations regimes. In
the present article, a simple case is investigated, which allows one to
enlighten the respective interest of different, classical methods, some of them
being rather delicate. This case is the 1D propagation in a homogeneous medium
having two purely resistive terminations, the calculation of the Green function
being done without any approximation using three methods. The first one is the
straightforward use of the closed-form solution in the frequency domain and the
residue calculus. Then the method of separation of variables (space and time)
leads to a solution depending on the initial conditions. The question of the
orthogonality and completeness of the complex-valued resonance modes is
investigated, leading to the expression of a particular scalar product. The
last method is the expansion in biorthogonal modes in the frequency domain, the
modes having eigenfrequencies depending on the frequency. Results of the three
methods generalize or/and correct some results already existing in the
literature, and exhibit the particular difficulty of the treatment of the
constant mode
Stacking order dynamic in the quasi-two-dimensional dichalcogenide 1T-TaS probed with MeV ultrafast electron diffraction
Transitions between different charge density wave (CDW) states in
quasi-two-dimensional materials may be accompanied also by changes in the
inter-layer stacking of the CDW. Using MeV ultrafast electron diffraction, the
out-of-plane stacking order dynamics in the quasi-two-dimensional
dichalcogenide 1T-TaS is investigated for the first time. From the
intensity of the CDW satellites aligned around the commensurate = 1/6
characteristic stacking order, it is found out that this phase disappears with
a 0.5 ps time constant. Simultaneously, in the same experiment, the emergence
of the incommensurate phase, with a slightly slower 2.0 ps time constant, is
determined from the intensity of the CDW satellites aligned around the
incommensurate = 1/3 characteristic stacking order. These results might be
of relevance in understanding the metallic character of the laser-induced
metastable "hidden" state recently discovered in this compound
Spin configurations in Co2FeAl0.4Si0.6 Heusler alloy thin film elements
We determine experimentally the spin structure of half-metallic
Co2FeAl0.4Si0.6 Heusler alloy elements using magnetic microscopy. Following
magnetic saturation, the dominant magnetic states consist of quasi-uniform
configurations, where a strong influence from the magnetocrystalline anisotropy
is visible. Heating experiments show the stability of the spin configuration of
domain walls in confined geometries up to 800 K. The switching temperature for
the transition from transverse to vortex walls in ring elements is found to
increase with ring width, an effect attributed to structural changes and
consequent changes in magnetic anisotropy, which start to occur in the narrower
elements at lower temperatures.Comment: 4 pages, 4 figure
Modeling of micro-perforated panels in a complex vibro-acoustic environment using patch transfer function approach
2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Magnetic switching in granular FePt layers promoted by near-field laser enhancement
Light-matter interaction at the nanoscale in magnetic materials is a topic of
intense research in view of potential applications in next-generation
high-density magnetic recording. Laser-assisted switching provides a pathway
for overcoming the material constraints of high-anisotropy and high-packing
density media, though much about the dynamics of the switching process remains
unexplored. We use ultrafast small-angle x-ray scattering at an x-ray
free-electron laser to probe the magnetic switching dynamics of FePt
nanoparticles embedded in a carbon matrix following excitation by an optical
femtosecond laser pulse. We observe that the combination of laser excitation
and applied static magnetic field, one order of magnitude smaller than the
coercive field, can overcome the magnetic anisotropy barrier between "up" and
"down" magnetization, enabling magnetization switching. This magnetic switching
is found to be inhomogeneous throughout the material, with some individual FePt
nanoparticles neither switching nor demagnetizing. The origin of this behavior
is identified as the near-field modification of the incident laser radiation
around FePt nanoparticles. The fraction of not-switching nanoparticles is
influenced by the heat flow between FePt and a heat-sink layer
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission
Objective:Rare inherited missense variants inSLC32A1, the gene that encodes the vesicular gamma-aminobutyric acid(GABA) transporter, have recently been shown to cause genetic epilepsy with febrile seizures plus. We aimed to clarifyif de novo missense variants inSLC32A1can also cause epilepsy with impaired neurodevelopment.Methods:Using exome sequencing, we identified four individuals with a developmental and epileptic encephalopathyand de novo missense variants inSLC32A1. To assess causality, we performed functional evaluation of the identifiedvariants in a murine neuronal cell culture model.Results:The main phenotype comprises moderate-to-severe intellectual disability, infantile-onset epilepsy within thefirst 18 months of life, and a choreiform, dystonic, or dyskinetic movement disorder. In silico modeling and functionalanalyses reveal that three of these variants, which are located in helices that line the putative GABA transport pathway,result in reduced quantal size, consistent with impairedfilling of synaptic vesicles with GABA. The fourth variant,located in the vesicular gamma-aminobutyric acid N-terminus, does not affect quantal size, but increases presynapticrelease probability, leading to more severe synaptic depression during high-frequency stimulation. Thus, variants invesicular gamma-aminobutyric acid can impair GABAergic neurotransmission through at least two mechanisms, byaffecting synaptic vesiclefilling and by altering synaptic short-term plasticity.Interpretation:This work establishes de novo missense variants inSLC32A1as a novel cause of a developmental andepileptic encephalopathy
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