742 research outputs found
Detecting bipolar depression from geographic location data
Objective: This work aims to identify periods of depression using geolocation movements recorded from mobile phones in a prospective community study of individuals with bipolar disorder (BD).
Methods: Anonymised geographic location recordings from 22 BD participants and 14 healthy controls (HC) were collected over 3 months. Participants reported their depressive symptomatology using a weekly questionnaire (QIDS-SR16). Recorded location data were pre-processed by detecting and removing imprecise data points and features were extracted to assess the level and regularity of geographic movements of the participant. A subset of features were selected using a wrapper feature selection method and presented to (a) a linear regression model and a quadratic generalised linear model with a logistic link function for questionnaire score estimation; and (b) a quadratic discriminant analysis classifier for depression detection in BD participants based on their questionnaire responses.
Results: HC participants did not report depressive symptoms and their features showed similar distributions to nondepressed BD participants. Questionnaire score estimation using geolocation-derived features from BD participants demonstrated an optimal mean absolute error rate of 3.73 while depression detection demonstrated an optimal (median±IQR) F1 score of 0.857±0.022 using 5 features (classification accuracy: 0.849±0.016; sensitivity: 0.839±0.014; specificity: 0.872±0.047).
Conclusion: These results demonstrate a strong link between geographic movements and depression in bipolar disorder.
Significance: To our knowledge this is the first community study of passively recorded objective markers of depression in bipolar disorder of this scale. The techniques could help individuals monitor their depression and enable healthcare providers to detect those in need of care or treatment
Identifying psychiatric diagnosis from missing mood data through the use of log-signature features
The availability of mobile technologies has enabled the efficient collection of prospective longitudinal, ecologically valid self-reported clinical questionnaires from people with psychiatric diagnoses. These data streams have potential for improving the efficiency and accuracy of psychiatric diagnosis as well predicting future mood states enabling earlier intervention. However, missing responses are common in such datasets and there is little consensus as to how these should be dealt with in practice. In this study, the missing-response-incorporated log-signature method achieves roughly 74.8% correct diagnosis, with f1 scores for three diagnostic groups 66% (bipolar disorder), 83% (healthy control) and 75% (borderline personality disorder) respectively. This was superior to the naive model which excluded missing data and advanced models which implemented different imputation approaches, namely, k-nearest neighbours (KNN), probabilistic principal components analysis (PPCA) and random forest-based multiple imputation by chained equations (rfMICE). The log-signature method provided an effective approach to the analysis of prospectively collected mood data where missing data was common and should be considered as an approach in other similar datasets. Because of treating missing responses as a signal, its superiority also highlights that missing data conveys valuable clinical information
Microwave observations of spinning dust emission in NGC6946
We report new cm-wave measurements at five frequencies between 15 and 18GHz
of the continuum emission from the reportedly anomalous "region 4" of the
nearby galaxy NGC6946. We find that the emission in this frequency range is
significantly in excess of that measured at 8.5GHz, but has a spectrum from
15-18GHz consistent with optically thin free-free emission from a compact HII
region. In combination with previously published data we fit four emission
models containing different continuum components using the Bayesian spectrum
analysis package radiospec. These fits show that, in combination with data at
other frequencies, a model with a spinning dust component is slightly preferred
to those that possess better-established emission mechanisms.Comment: submitted MNRA
First results from the Very Small Array -- I. Observational methods
The Very Small Array (VSA) is a synthesis telescope designed to image faint
structures in the cosmic microwave background on degree and sub-degree angular
scales. The VSA has key differences from other CMB interferometers with the
result that different systematic errors are expected. We have tested the
operation of the VSA with a variety of blank-field and calibrator observations
and cross-checked its calibration scale against independent measurements. We
find that systematic effects can be suppressed below the thermal noise level in
long observations; the overall calibration accuracy of the flux density scale
is 3.5 percent and is limited by the external absolute calibration scale.Comment: 9 pages, 10 figures, MNRAS in press (Minor revisions
Further Sunyaev-Zel'dovich observations of two Planck ERCSC clusters with the Arcminute Microkelvin Imager
We present follow-up observations of two galaxy clusters detected blindly via
the Sunyaev-Zel'dovich (SZ) effect and released in the Planck Early Release
Compact Source Catalogue. We use the Arcminute Microkelvin Imager, a dual-array
14-18 GHz radio interferometer. After radio source subtraction, we find a SZ
decrement of integrated flux density -1.08+/-0.10 mJy toward PLCKESZ
G121.11+57.01, and improve the position measurement of the cluster, finding the
centre to be RA 12 59 36.4, Dec +60 04 46.8, to an accuracy of 20 arcseconds.
The region of PLCKESZ G115.71+17.52 contains strong extended emission, so we
are unable to confirm the presence of this cluster via the SZ effect.Comment: 4 tables, 3 figures, revised after referee's comments and resubmitted
to MNRA
Standardizing Type Ia Supernova Absolute Magnitudes Using Gaussian Process Data Regression
We present a novel class of models for Type Ia supernova time-evolving
spectral energy distributions (SED) and absolute magnitudes: they are each
modeled as stochastic functions described by Gaussian processes. The values of
the SED and absolute magnitudes are defined through well-defined regression
prescriptions, so that data directly inform the models. As a proof of concept,
we implement a model for synthetic photometry built from the spectrophotometric
time series from the Nearby Supernova Factory. Absolute magnitudes at peak
brightness are calibrated to 0.13 mag in the -band and to as low as 0.09 mag
in the blueshifted -band, where the dispersion includes
contributions from measurement uncertainties and peculiar velocities. The
methodology can be applied to spectrophotometric time series of supernovae that
span a range of redshifts to simultaneously standardize supernovae together
with fitting cosmological parameters.Comment: 47 pages, 15 figures, accepted for publication by Astrophysical
Journa
Stellar Cruise Control: Weakened Magnetic Braking Leads to Sustained Rapid Rotation of Old Stars
Despite a growing sample of precisely measured stellar rotation periods and
ages, the strength of magnetic braking and the degree of departure from
standard (Skumanich-like) spindown have remained persistent questions,
particularly for stars more evolved than the Sun. Rotation periods can be
measured for stars older than the Sun by leveraging asteroseismology, enabling
models to be tested against a larger sample of old field stars. Because
asteroseismic measurements of rotation do not depend on starspot modulation,
they avoid potential biases introduced by the need for a stellar dynamo to
drive starspot production. Using a neural network trained on a grid of stellar
evolution models and a hierarchical model-fitting approach, we constrain the
onset of weakened magnetic braking. We find that a sample of stars with
asteroseismically-measured rotation periods and ages is consistent with models
that depart from standard spindown prior to reaching the evolutionary stage of
the Sun. We test our approach using neural networks trained on model grids
produced by separate stellar evolution codes with differing physical
assumptions and find that the choices of grid physics can influence the
inferred properties of the braking law. We identify the normalized critical
Rossby number as the
threshold for the departure from standard rotational evolution. This suggests
that weakened magnetic braking poses challenges to gyrochronology for roughly
half of the main sequence lifetime of sun-like stars.Comment: 26 pages, 10 figure
High resolution AMI Large Array imaging of spinning dust sources: spatially correlated 8 micron emission and evidence of a stellar wind in L675
We present 25 arcsecond resolution radio images of five Lynds Dark Nebulae
(L675, L944, L1103, L1111 & L1246) at 16 GHz made with the Arcminute
Microkelvin Imager (AMI) Large Array. These objects were previously observed
with the AMI Small Array to have an excess of emission at microwave frequencies
relative to lower frequency radio data. In L675 we find a flat spectrum compact
radio counterpart to the 850 micron emission seen with SCUBA and suggest that
it is cm-wave emission from a previously unknown deeply embedded young
protostar. In the case of L1246 the cm-wave emission is spatially correlated
with 8 micron emission seen with Spitzer. Since the MIR emission is present
only in Spitzer band 4 we suggest that it arises from a population of PAH
molecules, which also give rise to the cm-wave emission through spinning dust
emission.Comment: accepted MNRA
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