genoPlotR: comparative gene and genome visualization in R

Summary: The amount of gene and genome data obtained by next-generation sequencing technologies generates a need for comparative visualization tools. Complementing existing software for comparison and exploration of genomics data, genoPlotR automatically creates publication-grade linear maps of gene and genomes, in a highly automatic, flexible and reproducible way

High Resolution Spectroscopy of the Lamb Modes of a Plate near Normal Incidence

Abstract: Led by the complex roots of the dispersion relation for a plate in water, we searched for modes other than those identified by Lamb. Near the cutoff frequency of the S-and A-modes, we were succesfull. The targets used were a 1.5 mm thick aluminum plate and a 1.5 mm thick glass plate

Modulation of the peripheral blood transcriptome by the ingestion of probiotic yoghurt and acidified milk in healthy, young men

The metabolic health benefits of fermented milks have already been investigated using clinical biomarkers but the development of transcriptomic analytics in blood offers an alternative approach that may help to sensitively characterise such effects. We aimed to assess the effects of probiotic yoghurt intake, compared to non-fermented, acidified milk intake, on clinical biomarkers and gene expression in peripheral blood. To this end, a randomised, crossover study was conducted in fourteen healthy, young men to test the two dairy products. For a subset of seven subjects, RNA sequencing was used to measure gene expression in blood collected during postprandial tests and after two weeks daily intake. We found that the postprandial response in insulin was different for probiotic yoghurt as compared to that of acidified milk. Moreover changes in several clinical biomarkers were associated with changes in the expression of genes representing six metabolic genesets. Assessment of the postprandial effects of each dairy product on gene expression by geneset enrichment analysis revealed significant, similar modulation of inflammatory and glycolytic genes after both probiotic yoghurt and acidified milk intake, although distinct kinetic characteristics of the modulation differentiated the dairy products. The aryl hydrocarbon receptor was a major contributor to the down-regulation of the inflammatory genesets and was also positively associated with changes in circulating insulin at 2h after yoghurt intake (p = 0.05). Daily intake of the dairy products showed little effect on the fasting blood transcriptome. Probiotic yoghurt and acidified milk appear to affect similar gene pathways during the postprandial phase but differences in the timing and the extent of this modulation may lead to different physiological consequences. The functional relevance of these differences in gene expression is supported by their associations with circulating biomarkers

Veel zalmen sterven

status: publishe

Error analysis in physical experiments using Maple

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Technische Fiche Verlichting: Armaturen (Tecnolec)

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Maple as a didactical tool in physics education

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Fysische Optica in de professionele bachelor Optiek & Optometrie: docentenmobiliteit en studentenmobiliteit in de praktijk

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Experimental data supporting calculations of the angular derivative of the phase of the transmission coefficient of an elastic plate

From theory it is predicted that Lamb modes having a positive group velocity and those having a negative group velocity correspond to, respectively, negative and positive peaks on a spectrum showing the angular derivative of the phase of the transmission coefficient of the elastic plate. Experimental data are presented here that support this prediction. (C) 2002 Published by Elsevier Science B.V.status: publishe

Illuminance and glare of two light sources with different luminance distributions

status: publishe