Architectural Indoor Analysis: A Holistic Approach to Understand the Relation of Higher Education Classrooms and Academic Performance

The influence of learning space on users has been broadly accepted and tested. However, the literature has focused on single factor research, instead of holistic approaches. Additionally, lower educational levels have been the focus of interest, while higher education is moving towards multi-method teaching. This paper focuses on how learning spaces for different purposes (practice and lecture rooms) may influence academic performance from a holistic approach of learning physical environment perception. For this, the iPEP scale (Indoor physical environment perception) is used and validated through Cronbach Alpha and Exploratory Factorial Analysis. Then, multiple linear regression is conducted. The results indicate that iPEP measures near to 63 percent of the construct, which is structured in six factors. Moreover, linear regression analyses support previous literature concerning the influence of learning physical environment on academic performance (R2 = 0.154). The differences obtained between practice and lecture room in terms of predictor variables bring to the light the need to diagnose learning environments before designing changes in educational buildings. This research provides a self-reported way to measure indoor environments, as well as evidence concerning the modern university, which desires to combine several teaching methods

Superovulation, in vivo Embryo Recovery and Cryopreservation for Aoudad (Ammotragus Lervia) Females Using Osmotic Pumps and Vitrification : A Preliminary Experience and its Implications for Conservation

We thank all of the administrative, veterinary and animal keeper staff of the Leon Zoological Park and the embryologists (especially to Claudia Gonzalez) of the Instituto de Ciencias en Reproducción Humana, also to J.I Castillo-Quan for critical reading of the manuscript. This work was partially supported by grants 0105961/10110/194/09 to RF, 59716 to JPRU from CONACYT and grant 107996 to JPRU from FOMIXYucatán 2008. JLS was supported by a doctoral scholarship from CONACYT (240847).Peer reviewedPublisher PD

Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cells

This is an open-access paper.Cytogenetic studies in clonal plasma cell disorders have mainly been done in whole bone marrow or CD138+ microbead-enriched plasma cells and suggest that recurrent immunoglobulin heavy chain translocations - e.g. t(4;14) - are primary oncogenetic events. The aim of this study was to determine cytogenetic patterns of highly purified aberrant plasma cells (median purity ≥98%) in different clonal plasma cell disorders. We analyzed aberrant plasma cells from 208 patients with multiple myeloma (n=148) and monoclonal gammopathy of undetermined significance (n=60) for the presence of del(13q14), del(17p13) and t(14q32) using multicolor interphase fluorescence in situ hybridization. Additionally, immunoglobulin heavy chain gene arrangements were analyzed and complementarity determining region 3 was sequenced in a subset of patients and combined multicolor interphase fluorescence in situ hybridization/immunofluorescent protein staining analyses were performed in selected cases to confirm clonality and cytogenetic findings. At diagnosis, 96% of cases with multiple myeloma versus 77% of monoclonal gammopathy of undetermined significance cases showed at least one cytogenetic alteration and/or hyperdiploidy. The cytogenetic heterogeneity of individual cases reflected coexistence of cytogenetically-defined aberrant plasma cell clones, and led to the assumption that karyotypic alterations were acquired stepwise. Cases of multiple myeloma and monoclonal gammopathy of undetermined significance frequently showed different but related cytogenetic profiles when other cytogenetic alterations such as deletions/gains of the immunoglobulin heavy chain or the fibroblast growth factor receptor 3 were additionally considered. Interestingly, in 24% of multiple myeloma versus 62% of monoclonal gammopathy of undetermined significance patients with an immunoglobulin heavy chain translocation, aberrant plasma cells with and without t(14q32) coexisted in the same patient. Our data suggest that recurrent immunoglobulin heavy chain translocations might be absent in the primordial plasma cell clone in a significant proportion of patients with clonal plasma cell disorders carrying these cytogenetic alterations.This work was partially supported by grants from the Fundacion Memoria de Don Samuel Solorzano Barruso, Salamanca, Spain (FS/4-2010). The authors would also like to thank the Dr. Werner Jackstädt Foundation (Wuppertal, Germany) for grant supporting the work of Martin Schmidt-Hieber. The authors would like to thank the Cooperative Research Thematic Network (RTICs; RTICC RD06/0020/0035, RD06/0020/0006 and G03/136), MM Jevitt, SL firm, Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria (FIS: PI060339; 02/0905; 01/0089/01-02; PS09/01897) and Gerencia Regional de Salud de Castilla y León; Ayuda de Excelencia de Castilla y León, Consejeria de Educación (EDU/894/2009, GR37), and Consejería de Sanidad (557/A/10), Junta de Castilla y León, Valladolid, Spain for supporting this study. JMS is supported by a grant (CP05/00321) from the ISCIII, Ministerio de Ciencia e Innovacion, Madrid, Spain.Peer Reviewe

Neotectonic Activity in the Low-Strain Broken Foreland (Santa Bárbara System) of the North-Western Argentinean Andes (26°S)

Uplift in the broken Andean foreland of the Argentine Santa Bárbara System (SBS) is associated with the contractional reactivationof basement anisotropies, similar to those reported from the thick-skinned Cretaceous-Eocene Laramide province of NorthAmerica. Fault scarps, deformed Quaternary deposits and landforms, disrupted drainage patterns, and medium-sizedearthquakes within the SBS suggest that movement along these structures may be a recurring phenomenon, with yet to bedefined repeat intervals and rupture lengths. In contrast to the Subandes thrust belt farther north, where eastward-migratingdeformation has generated a well-defined thrust front, the SBS records spatiotemporally disparate deformation along structuresthat are only known to the first order. We present herein the results of geomorphic desktop analyses, structural fieldobservations, and 2D electrical resistivity tomography and seismic-refraction tomography surveys and an interpretation ofseismic reflection profiles across suspected fault scarps in the sedimentary basins adjacent to the Candelaria Range (CR)basement uplift, in the south-central part of the SBS. Our analysis in the CR piedmont areas reveals consistency between theresults of near-surface electrical resistivity and seismic-refraction tomography surveys, the locations of prominent fault scarps,and structural geometries at greater depth imaged by seismic reflection data. We suggest that this deformation is driven bydeep-seated blind thrusting beneath the CR and associated regional warping, while shortening involving Mesozoic and Cenozoicsedimentary strata in the adjacent basins was accommodated by layer-parallel folding and flexural-slip faults that cut throughQuaternary landforms and deposits at the surface.Fil: Arnous, Ahmad. Instituto Miguel Lillo, Universidad Nacional de Tucumán; Argentina. University Of Postdam; AlemaniaFil: Zeckra, Martin. University Of Postdam; AlemaniaFil: Venerdini, Agostina Lia. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Geofísica y Astronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Centro de Investigaciones de la Geosfera y Biosfera. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones de la Geosfera y Biosfera; ArgentinaFil: Alvarado, Patricia Monica. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Geofísica y Astronomía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Centro de Investigaciones de la Geosfera y Biosfera. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Centro de Investigaciones de la Geosfera y Biosfera; ArgentinaFil: Arrowsmith, Ramón. School Of Earth And Space Exploration, Arizona State Un; Estados UnidosFil: Guillemoteau, Julien. University Of Postdam; AlemaniaFil: Landgraf, Angela. University Of Postdam; AlemaniaFil: Gutiérrez, Antonio. Instituto Miguel Lillo, Universidad Nacional de Tucumán; ArgentinaFil: Strecker, Manfred R.. University Of Postdam; Alemani

Los aminoácidos azufrados mejoran la eficacia de utilización del pienso.

Las recomendaciones de metronina+ostina obtenidas a partir de diferentes estudios presentan una gran variabilidad, por lo que es necesario investigar cuál es la relación óptima metronina+ostina /lisina digestible para optimizar los rendimientos de gallinas ponedoras

A human reproductive approach to the study of infertility in chimpanzees : An experience at Leon's Zoological Park, Mexico

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Hydraulic Traits Emerge as Relevant Determinants of Growth Patterns in Wild Olive Genotypes Under Water Stress

The hydraulic traits of plants, or the efficiency of water transport throughout the plant hydraulic system, could help to anticipate the impact of climate change and improve crop productivity. However, the mechanisms explaining the role of hydraulic traits on plant photosynthesis and thus, plant growth and yield, are just beginning to emerge. We conducted an experiment to identify differences in growth patterns at leaf, root and whole plant level among four wild olive genotypes and to determine whether hydraulic traits may help to explain such differences through their effect on photosynthesis. We estimated the relative growth rate (RGR), and its components, leaf gas exchange and hydraulic traits both at the leaf and whole-plant level in the olive genotypes over a full year. Photosynthetic capacity parameters were also measured. We observed different responses to water stress in the RGRs of the genotypes studied being best explained by changes in the net CO2 assimilation rate (NAR). Further, net photosynthesis, closely related to NAR, was mainly determined by hydraulic traits, both at leaf and whole-plant levels. This was mediated through the effects of hydraulic traits on stomatal conductance. We observed a decrease in leaf area: sapwood area and leaf area: root area ratios in water-stressed plants, which was more evident in the olive genotype Olea europaea subsp. guanchica (GUA8), whose RGR was less affected by water deficit than the other olive genotypes. In addition, at the leaf level, GUA8 water-stressed plants presented a better photosynthetic capacity due to a higher mesophyll conductance to CO2 and a higher foliar N. We conclude that hydraulic allometry adjustments of whole plant and leaf physiological response were well coordinated, buffering the water stress experienced by GUA8 plants. In turn, this explained their higher relative growth rates compared to the rest of the genotypes under water-stress conditions

FSSCat Mission description and first scientific results of the FMPL-2 onboard 3CAT-5/A

FSSCat, the “Federated Satellite Systems/ 3 Cat-5” mission was the winner of the 2017 ESA S^3 (Sentinel Small Satellite) Challenge and overall winner of the Copernicus Masters competition. FSSCat consists of two 6 unit cubesats carrying on board UPC's Flexible Microwave Payload - 2 (FMPL-2), an L-band microwave radiometer and GNSS-Reflectometer implemented in a software defined radio, and Cosine's HyperScout-2 visible and near infrared + thermal infrared hyperspectral imager, enhanced with PhiSat-1, a on board Artificial intelligence experiment for cloud detection. Both spacecrafts include optical and UHF inter-satellite links technology demonstrators, provided by Golbriak Space and UPC, respectively. This paper describes the mission, and the main scientific results of the FMPL-2 obtained during the first three months of the mission, notably the sea ice concentration and thickness, and the downscaled soil moisture products over the Northern hemisphere.This work was supported by 2017 ESA S 3 challenge and Copernicus Masters overall winner award (“FSSCat” project) and ESA project “FSSCat Validation Experiment in MOSAIC”, by the Spanish Ministry of Science, Innovation and Universities, "Sensing with Pioneering Opportunistic Techniques" SPOT, grant RTI2018-099008- BC21/AEI/10.13039/501100011033, and by the Unidad de Excelencia Maria de Maeztu MDM-2016-0600.Peer ReviewedArticle signat per 25 autors/es: A. Camps 1,2; J.F. Munoz‐Martin 1; J.A. Ruiz‐de‐Azua 1,2; L. Fernandez 1; A. Perez-Portero 1; D. Llavería 1; C. Herbert 1; M. Pablos 3; A. Golkar 4,1; A. Gutiérrrez 5; C. António 5; J. Bandeiras 5; J. Andrade 5; D. Cordeiro 5; S. Briatore 4,6; N. Garzaniti 4,6; F. Nichele 7; R. Mozzillo 7; A. Piumatti 7; M. Cardi 7; M. Esposito 8; B. Carnicero Dominguez 9; M. Pastena 9; G. Filippazzo 10; A. Reagan 10 // 1. Universitat Politècnica de Catalunya, Barcelona, Spain; 2. Institut d’Estudis Espacials de Catalunya, Barcelona, Spain; 3. Institut de Ciències del Mar (ICM-CSIC) & Barcelona Expert Center (BEC) on Remote Sensing, Barcelona, Spain; 4. Skolkovo Institute of Science and Technology, Moscow, Russia; 5. Deimos Eng., Lisbon, Portugal; 6. Golbriak Space, Tallin, Estonia; 7. Tyvak International, Torino, Italy; 8. Cosine, Oosteinde, The Netherlands; 9. ESA ESTEC, Noordwijk, The Netherlands; 10. ESA ESRIN, Frascati, ItalyPostprint (author's final draft

Treatment‐free remission after dasatinib in patients with chronic myeloid leukaemia in chronic phase with deep molecular response: Final 5‐year analysis of DASFREE

Patients with chronic myeloid leukaemia in chronic phase (CML-CP) who have a sustained deep molecular response (DMR) are eligible to discontinue treatment and attempt treatment-free remission (TFR). In the DASFREE study (ClinicalTrials.gov; NCT01850004), the 2-year TFR rate after dasatinib discontinuation was 46%; here we present the 5-year update. Patients with a stable DMR after ≥2 years of dasatinib therapy discontinued treatment and were followed for 5 years. At a minimum follow-up of 60 months, in 84 patients discontinuing dasatinib, the 5-year TFR rate was 44% (n = 37). No relapses occurred after month 39 and all evaluable patients who relapsed and restarted dasatinib (n = 46) regained a major molecular response in a median of 1.9 months. The most common adverse event during the off-treatment period was arthralgia (18%, 15/84); a total of 15 withdrawal events were reported in nine patients (11%). At the 5-year final follow-up, almost half of the patients who discontinued dasatinib after a sustained DMR maintained TFR. All evaluable patients who experienced a relapse quickly regained a DMR after restarting dasatinib, demonstrating that dasatinib discontinuation is a viable and potentially long-term option in patients with CML-CP. The safety profile is consistent with the previous report

Association of immune responses of Zebu and Holstein-Friesian cattle and resistance to mycobacteria in a BCG challenge model

Mycobacterium bovis is the main cause of bovine tuberculosis (BTB) in cattle and can also infect humans. Zebu cattle are considered more resistant to some infectious diseases compared with Holstein‐Friesian (HF) cattle, including BTB. However, epidemiological studies may not take into account usage differences of the two types of cattle. HF cattle may suffer greater metabolic stress due to their more or less exclusive dairy use, whereas Zebu cattle are mainly used for beef production. In experiments conducted so far, the number of animals has been too small to draw statistically robust conclusions on the resistance differences between these cattle breeds. Here, we used a BCG challenge model to compare the ability of naïve and vaccinated Zebu and HF cattle to control/kill mycobacteria. Young cattle of both breeds with similar ages were housed in the same accommodation for the duration of the experiment. After correcting for multiple comparisons, we found no difference between naïve HF and Zebu (ρ = 0.862) cattle. However, there was a trend for vaccinated HF cattle to have lower cfu numbers than non‐vaccinated HF cattle (ρ = 0.057); no such trend was observed between vaccinated and non‐vaccinated Zebu cattle (ρ = 0.560). Evaluation of antigen‐specific IFNγ secretion by PBMC indicated that Zebu and HF cattle differed in their response to mycobacteria. Thus, whilst there may be difference in immune responses, our data indicate that with the number of animals included in the study and under the conditions used in this work, we were unable to measure any differences between Zebu and HF cattle in the overall control of mycobacteria. Whilst determination of different susceptibilities between Zebu and HF cattle using the BCG challenge model will require larger numbers of animals than the number of animals used in this experiment, these data should inform future experiments