Simulation of object motion in a bubbling fluidized bed using a Monte Carlo method

The motion of a large neutrally-buoyant object immersed in a 2D bubbling fluidized bed was simulated using a Monte Carlo method. The object vertical trajectory within the bed was simulated for a range of dimensionless gas velocities using a simple 1D model. The main characteristics of the object motion were obtained from the trajectory simulation and compared with experimental evidence giving good results. On a second step, the time scale of the motion is introduced in the simulated data by means of well-known 2D correlations for the bubble and dense phase velocity. The circulation time of an object (from the instant when it leaves the freeboard and sinks in the dense phase till the moment it reappears back in the surface) was then obtained and compared with experimental data, showing a general agreement. Finally, an extrapolation for a 3D fluidized bed was made following a similar procedure.This work has been partially supported by the National Energy Program of Spanish Government (DPI2009-10518 MICINN) and the Madrid Community (CARDENER-CM S2009ENE-1660).Publicad

Circulation of an object immersed in a bubbling fluidized bed

The motion of a large object in a bubbling fluidized bed was experimentally studied using digital image analysis (DIA). The experiments were performed in a 2 D bubbling fluidized bed with glass spheres as bed material. The object motion was measured using non intrusive tracking techniques, while independent measurements of the dense phase velocity (using Particle Image Velocimetry (PIV)) and bubble velocity (using DIA) were carried out. The effect of the dimensionless gas velocity on the object motion was also analyzed. This work characterizes the circulation patterns of an object with a density similar to that of the bed, but much larger in size. Object size and density remained constant throughout the experiments. A comparison between the motion of sinking objects and the motion of the dense phase provided evidence of the feeble effect of buoyant forces on the motion of sinking objects. In contrast, the motion of rising objects is linked to the motion of bubbles. It was found that objects may be raised to the surface of the bed either by the action of a single bubble (one jump) or by several passing bubbles (multiple jumps). Based on these results, the circulation time of objects throughout the bed is a function of two parameters: the maximumdepth attained by an object and the number of jumps during its rising path. This relationship is presented along and the multiple jumps phenomenon is studied in detail. Finally, an estimate of the circulation time of an object based on semi empirical expressions is presented for different dimensionless gas velocities. The probability density function of the circulation time shows two different modes as the object was less prone to be raised atmoderate depths. The estimate of the circulation time was found to be in good agreement with our experimental dataThis work has been partially supported by the National Energy Program of the Spanish Department of Science and Education (ENE2006-01401) and the Madrid Community (CCG07-uc3m/amb-3412 andCCG08-uc3m/amb-4227)Publicad

Analysis of biomass and sewage sludge devolatilization using the distributed activation energy model

Procceedings of: 3th Conference on renewables for desert regions. Global Conference on Renewable energy and Energy Efficiency for Desert Regions 2011 "GCREEDER 2011". Tokk place 2011 April 26-28,in Aman (Jordanian). The Event Web site is http://www.solarthermalworld.org/content/gcreeder-2011-amanThe thermal decomposition of biomass (pine pellets) and sewage sludge was studied using thermogravimetric analysis under an inert atmosphere and the Distributed Activation Energy Model (DAEM) was employed. The activation energy and the frequency factor that characterize the kinetics were determined for both samples. A simplification of the process for prediction of devolatilization curves was proposed, evaluating its validity for both cases. The simplified method was found to combine both simplicity and low deviations with experimental data.This work has been partially supported by the National Energy Program of the Spanish Department of Science and Education (ENE2006-01401), the Spanish Government (DPI2009-10518 MICINN) and the Madrid Community (CCG07-uc3 m/amb-3412, CCG08-uc3 m/amb-4227 and P2009/ENE- 1660).Publicad

Buoyancy effects on objects moving in a bubbling fluidized bed

The effect of buoyant forces on the motion of a large object immersed in a bubbling fluidized bed (BFB) was experimentally studied using digital image analysis. The experiments were performed in a 2 D bubbling fluidized bed with glass spheres as bed material and cylindrical objects with different densities and sizes. The object motion was measured using non intrusive tracking techniques. The effect of gas velocity was also analyzed. The circulation of an object in a BFB is defined by several parameters. The object might be able to circulate homogeneously throughout the bed or stay in preferred regions, such as the splash zone or the bottom zone. While circulating, the object moves back and forth between the surface of the bed and the inner regions, performing a series of cycles. Each cycle is composed by sinking and rising paths, which can be one or several, depending on whether a passing bubble is able to lift the object to the surface or the object is detached from it or its drift at an intermediate depth. Therefore, the number of rising paths or number of jumps that the object undergo in a cycle, interleaved with sinking paths, and the maximum attained depth characterize each cycle, together with the mean sinking and rising velocities of the object. In this work, experimental measurements of the probability distributions of the number of jumps and the maximum attained depth, the axial homogeneity of object motion and rising and sinking object velocities are presented for objects with different sizes and densities. The results show a coherent behavior, independent of density and size, for the probability distributions of the number of jumps. This is also true for the maximum attained depth, but only when a proper circulation throughout the bed is ensured. Such a proper circulation and axial homogeneity is, on the other hand, much affected by object density, size and gas velocity. Rising and sinking velocities are highly dependent on gas velocity, as established in well known models of bubble and dense phase velocities. Nevertheless, rising velocities are practically unaffected by object density or size, while sinking velocities show a low dependence on density and a steeper one on size. These results suggest that buoyant forces are relevant during the sinking process, and almost neutral during the rising pathThis work has been partially supported by the National Energy Program of the Spanish Department of Science and Education (ENE2006-01401), the Spanish Government (DPI2009-10518 MICINN) and the Madrid Community (CCG07-uc3m/amb-3412 and CCG08-uc3m/amb-4227)Publicad

Musicoterapia en una Unidad de Cuidados Intensivos Neonatales: experiencia benéfica para el binomio

ResumenIntroducciónDesde hace varios años se está utilizando la música como herramienta terapéutica y preventiva en la neonatología, se han documentado en un gran número de artículos de investigación, sin embargo, en México esta técnica es poco utilizada.ObjetivoMejorar las condiciones de los neonatos atendidos en una Unidad de Cuidados Intensivos (UCIN) y sus familiares, mediante el uso de musicoterapia, para minimizar el estrés y los daños colaterales.Materiales y métodosUn grupo de 2 neonatólogos, 3 residentes de pediatría, 10 enfermeras y un concertista profesional de violín, llevaron a cabo 6 sesiones musicales semanales en la Unidad de Cuidados Intensivos Neonatales Externos del Hospital Civil de Guadalajara. Durante el concierto se valoró individualmente a cada neonato, registrando los signos vitales por monitorización electrónica, además se registró el estado anímico de los familiares.ResultadosDurante las sesiones de música los neonatales no presentaron cambios significativos en sus constantes vitales, en el personal de la UCIN y en los padres de recién nacidos hospitalizados se vieron efectos benéficos, refiriendo disminución del estrés y altos índices de satisfacción.ConclusionesLa música puede tener un efecto positivo como terapia coadyuvante en neonatos de alto riesgo, principalmente en prematuros. Se recomienda difundir y aplicar esta metodología en las UCIN del país.AbstractIntroductionSince several years ago, music has been used as a therapeutic and preventive tool in neonatology. A great number of research papers have been written on the subject; however, this technique is rarely used in Mexico.ObjectiveTo improve the condition of neonates at Neonatal Intensive Care Units (NICU) and their relatives, in order to minimize any stress and collateral damage.Material and methods: A group of two neonatologists, 3 residents, 10 nurses and a professional concert violinist, conducted six weekly music sessions in the Outpatient Neonatal Intensive Care Unit (ONICU) of our institution. During the concert, we individually assessed each newborn, recording vital signs through electronic monitoring; additionally, we recorded the mood of any other family members present.ResultsDuring the music sessions, the neonatal patients showed no significant changes in vital signs; yet, ONICU staff and the parents/relatives of hospitalized newborns showed beneficial effects, reporting decreased stress and high levels of satisfaction.ConclusionsMusic can have a positive effect as adjunctive therapy in high-risk newborns, especially in premature babies. We therefore recommend applying this methodology in the ONICU

Experimental study of solid mixing mechanism in a 2D fluidized bed

The main mechanism of solids mixing in bubbling fluidized beds is well understood. When a bubble rises through the bed, it carries a wake of particles to the bed surface. A downflow of solids exists in the region surrounding the rising bubbles, resulting on an overall convective circulation of particles in the axial direction (1). In this work, a new method to characterize solids mixing in a 2D fluidized bed is developed. This mixing index is able to macroscopically characterize the rate of mixing in a fluidized bed by means of DIA. The mixing index is analogous to the Lacey’s mixing index of particle mixing (2). The experiments are carried out in a pseudo-2D fluidized bed using glass beads as bed material. These glass beads have the same density and diameter but half of them are painted in black (Figure-1). At the beginning of each experiment, the particles are placed in a perfectly lateral segregated state and then the fluidizing air is suddenly injected while images are recorded. Two different regions are detected in the time evolution of the mixing index. The first one is a region with a fast convective mixing, where the initial boundary between the black and white particles is broken. The second one is a region where diffusive mixing is dominant and the particles clusters are mixed with the bulk following an exponential trend (Figure-1). These two mechanisms, as well as the overall mixing time are characterized for different superficial gas velocities and particle sizes. REFERENCES M.J. Rhodes, X.S. Wang, M. Nguyen, P. Stewart, K. Liffman. Study of mixing in gas-fluidized beds using DEM model. Chem. Eng. Sci., 56(8):2859-2866, 2001. P.M.C. Lacey. Developments in the theory of particle mixing. J. Appl. Chem., 4:257-268, 1954. Please click Additional Files below to see the full abstract

Vesicle fusion as a target process for the action of sphingosine and its derived drugs

The fusion of membranes is a central part of the physiological processes involving the intracellular transport and maturation of vesicles and the final release of their contents, such as neurotransmitters and hormones, by exocytosis. Traditionally, in this process, proteins, such SNAREs have been considered the essential components of the fusion molecular machinery, while lipids have been seen as merely structural elements. Nevertheless, sphingosine, an intracellular signalling lipid, greatly increases the release of neurotransmitters in neuronal and neuroendocrine cells, affecting the exocytotic fusion mode through the direct interaction with SNAREs. Moreover, recent studies suggest that FTY-720 (Fingolimod), a sphingosine structural analogue used in the treatment of multiple sclerosis, simulates sphingosine in the promotion of exocytosis. Furthermore, this drug also induces the intracellular fusion of organelles such as dense vesicles and mitochondria causing cell death in neuroendocrine cells. Therefore, the effect of sphingosine and synthetic derivatives on the heterologous and homologous fusion of organelles can be considered as a new mechanism of action of sphingolipids influencing important physiological processes, which could underlie therapeutic uses of sphingosine derived lipids in the treatment of neurodegenerative disorders and cancers of neuronal origin such neuroblastoma

Virulence in Mice of a Toxoplasma gondii Type II Isolate Does Not Correlate With the Outcome of Experimental Infection in Pregnant Sheep

Toxoplasma gondii is an apicomplexan parasite that infects almost all warm-blooded animals. Little is known about how the parasite virulence in mice extrapolates to other relevant hosts. In the current study, in vitro phenotype and in vivo behavior in mice and sheep of a type II T. gondii isolate (TgShSp1) were compared with the reference type II T. gondii isolate (TgME49). The results of in vitro assays and the intraperitoneal inoculation of tachyzoites in mice indicated an enhanced virulence for the laboratory isolate, TgME49, compared to the recently obtained TgShSp1 isolate. TgShSp1 proliferated at a slower rate and had delayed lysis plaque formation compared to TgME49, but it formed more cyst-like structures in vitro. No mortality was observed in adult mice after infection with 1-105 tachyzoites intraperitoneally or with 25-2, 000 oocysts orally of TgShSp1. In sheep orally challenged with oocysts, TgME49 infection resulted in sporadically higher rectal temperatures and higher parasite load in cotyledons from ewes that gave birth and brain tissues of the respective lambs, but no differences between these two isolates were found on fetal/lamb mortality or lesions and number of T. gondii-positive lambs. The congenital infection after challenge at mid-pregnancy with TgShSp1, measured as offspring mortality and vertical transmission, was different depending on the challenged host. In mice, mortality in 50% of the pups was observed when a dam was challenged with a high oocyst dose (500 TgShSp1 oocysts), whereas in sheep infected with the same dose of oocysts, mortality occurred in all fetuses. Likewise, mortality of 9 and 27% of the pups was observed in mice after infection with 100 and 25 TgShSp1 oocysts, respectively, while in sheep, infection with 50 and 10 TgShSp1 oocysts triggered mortality in 68 and 66% of the fetuses/lambs. Differences in vertical transmission in the surviving offspring were only found with the lower oocyst doses (100% after infection with 10 TgShSp1 oocysts in sheep and only 37% in mice after infection with 25 TgShSp1 oocysts). In conclusion, virulence in mice of T. gondii type II isolates may not be a good indicator to predict the outcome of infection in pregnant sheep

Cost-effectiveness of breast cancer control strategies in Central America: The cases of Costa Rica and Mexico

__Abstract__ This paper reports the most cost-effective policy options to support and improve breast cancer control in Costa Rica and Mexico. Total costs and effects of breast cancer interventions were estimated using the health care perspective and WHO-CHOICE methodology. Effects were measured in disability-adjusted life years (DALYs) averted. Costs were assessed in 2009 United States Dollars (US$). To the extent available, analyses were based on locally obtained data. In Costa Rica, the current strategy of treating breast cancer in stages I to IV at a 80$4,739 per DALY averted. At a coverage level of 95%, biennial clinical breast examination (CBE) screening could improve Costa Rica's population health twofold, and can still be considered very cost-effective (ICER US$5,964/DALY). For Mexico, our results indicate that at 95$5,021/DALY). If more resources are available in Mexico, biennial mammography screening for women 50-70 yrs (ICER US$12,718/DALY), adding trastuzumab (ICER US$13,994/DALY) or screening women 40-70 yrs biennially plus trastuzumab (ICER US$17,115/DALY) are less cost-effective options. We recommend both Costa Rica and Mexico to engage in MAR, CBE or mammography screening programs, depending on their budget. The results of this study should be interpreted with caution however, as the evidence on the intervention effectiveness is uncertain. Also, these programs require several organizational, budgetary and human resources, and the accessibility of breast cancer diagnostic, referral, treatment and palliative care facilities should be improved simultaneously. A gradual implementation of early detection programs should give the respective Ministries of Health the time to negotiate the required budget, train the required human resources and understand possible socioeconomic barriers