51 research outputs found
Brand Personality and Gender – How there is a woman inside Evian and a man inside Nike
The thesis provides with the broad overview about the consumer awareness of the gender dimension within brand personalities. The research contributes to branding theory and gender studies and demonstrates that consumer gender influences does not influence the perceived brand personality gender. However, it also shows that consumers prefer brands with a clear gender, but not necessarily the same gendered brands
Thermal roughening of an SOS-model with elastic interaction
We analyze the effects of a long-ranged step-step interaction on thermal
roughening within the framework of a solid-on-solid model of a crystal surface
by means of Monte Carlo simulation. A repulsive step-step interaction is
modeled by elastic dipoles located on sites adjacent to the steps. In order to
reduce the computational effort involved in calculating interaction energy
based on long-ranged potentials, we employ a multi-grid scheme. As a result of
the long-range character of the step interaction, the roughening temperature
increases drastically compared to a system with short-range cutoff as a
consequence of anti-correlations between surface defects
Karakterisering av alkoholmodulering av en pentamerisk ligandstyrd jonkanal med elektrofysiologi och molekylärdynamiksimuleringar
Pentameric ligand-gated ion channels (pLGICs) are membrane receptors that play a crucial role in every living organism. The pLGIC protein structure forms a pore through the membrane of a cell that can let specific ions pass through, upon activation by endogenous agonists. pLGICs are allosterically modulated by ligands binding at allosteric sites, that either stabilize a certain conformation or change the binding affinity of the endogenous agonist. However, much remains unknown about the exact way in which these modulators bind to and affect pLGICs. An increased understanding could help in the search for novel and/or more effective target drugs. With this masters thesis, I hope to contribute by investigating the modulatory effect of ethanol on the bacterial Gloeobacter ligand-gated ion channel (GLIC). This has been done by performing oocyte electrophysiology recordings and analysis of molecular dynamics simulations, both with and without ethanol, and of four separate variants of GLIC that are either potentiated or inhibited by ethanol. Two possible allosteric sites were discovered in a transmembraneintrasubunit pocket: a potentiating allosteric site close to the M2 helix and residue V242, as well as an inhibitory membrane- and M4 helix-close intrasubunit site. Finally, evidence was found that could support a previously suggested inhibitory allosteric site in the pore around the 9’ hydrophobic gate.Pentameriska ligandstyrda jonkanaler (pLGICs) är membranreceptorer som utgör vitala delar av varje levande organism. pLGICs proteinstruktur formar en por genom cellmembranet, som kan släppa igenom specifika joner efter aktivering av endogena agonister. pLGICs är allostermodulerade av ligander som binder vid allostera säten och som därigenom antingen stabiliserar en viss form eller förändrar den endogena agonistens bindningsstyrka. Emellertid saknas fortfarande mycket kunskap på detaljnivå om hur dessa modulatorer binder sig till och påverkar kanalerna. En ökad förståelse skulle hjälpa forskningen efter nya och/eller mer effektiva mediciner. Mitt examensarbetehoppas bidra genom att studera hur etanol modulerar den bakteriella ligandstyrda jonkanalen GLIC från Gloeobacter. Det har gjorts genom elektrofysiologimätningar på oocyter och analys av molekulärdynamiksimuleringar, båda av fyra olika GLIC-varianter, som antingen potentieras eller hämmas av etanol, och med eller utan etanol. Två allostera säten upptäcktes i det transmembrana intrasubenhetområdet: ett säte för potentiering nära M2 helixen och aminosyran V242, och ett hämmande säte nära membranet och helix M4. Slutligen hittades tecken som kan styrka existensen av det tidigare föreslagna hämmande allostera sätet i poren kring den hydrophoba porten
Masters of World Architecture: Alvar Aalto
Over 80 pages of reproductions including photographs, plans and drawings.https://nsuworks.nova.edu/nsudigital_flwbooks/1139/thumbnail.jp
Plan de negocios : Swell Craft
Fil: Gutheim, Pablo. Universidad de San Andrés. Escuela de Administración y Negocios; Argentina."La idea central es la fabricación de una lancha open de 17 pies, segmento de
mayor volumen en el mercado. Para ello se creará un astillero con
capacidades para el diseño, ingeniería y fabricación de embarcaciones
deportivas con la posibilidad de volcarse a estructuras en materiales
compuestos como potencial de crecimiento/expansión.
Constituye una oportunidad de negocios en vistas que el mercado se
encuentra en expansión mediante grandes inversiones en curso de
guarderías ampliando la capacidad disponible.
La industria naval recreativa en Argentina es relativamente importante, se
caracteriza por buenos productos, de calidad aceptable, pero realizados con
grandes desfases tecnológicos y poca capacidad de innovación.
En 2014, se matricularon 3378 lanchas de 5 a 7 metros, por lo tanto se
estima en plena producción tomar el 1.4% de este mercado dejando grandes
perspectivas de crecimiento, según los datos de Prefectura Naval Argentina y
la Cámara de la industria.
Se plantea emplear un método de construcción novedoso que mejora las
propiedades y la calidad del producto, es más amigable con el medio
ambiente y requiere de menos mano de obra.
El cliente al cual está direccionado el producto es A, B siendo estos de clase
media alta en adelante ya que se trata de un producto recreativo aspiracional
cuyo valor es sensiblemente elevado."Arroyo, Maximilian
Alvar Aalto
128 hlm.;ill.;bibl.;index;25c
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