380 research outputs found
Do neutrons publish? A neutron publication survey 2005-2015
Publication in scientific journals is the main product of scientific
research. The amount of papers published, their placement in high impact
journals, and their citations are used as a measure of the productivity of
individual scientists, institutes or fields of science. To give a profound
basis on the publication record and the quality of the publication efforts in
neutron scattering, a survey has been done following the approach to use
bibliographic databases. Questions to be addressed by this survey are: Is the
productivity of research with neutrons changing over the years? Which is the
geographic distribution in this field of research? Which ones are leading
facilities? Is the quality of publications changing? The main results found are
presented
Surfactant mixtures at the oil–water interface
NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Colloid and Interface Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in JOURNAL OF COLLOID AND INTERFACE SCIENCE, VOL 398, (2013) DOI 10.1016/j.jcis.2013.01.06
Cardiolipin, α-d-glucopyranosyl, and l-lysylcardiolipin from Gram-positive bacteria: FAB MS, monofilm and X-ray powder diffraction studies
AbstractCardiolipin preparations from Streptococcus B, Listeria welshimeri, Staphylococcus aureus, and a glucosyl and lysyl derivative of cardiolipin were analysed for fatty acid composition and fatty acid combinations. Three different fatty acid patterns are described and up to 17 molecular species were identified in Streptococcus B lipids by high resolution FAB MS. The physicochemical properties of these lipids were characterised in the sodium salt form by monofilm experiments and X-ray powder diffraction. All lipids formed stable monofilms. The minimal space requirement of unsubstituted cardiolipin was dictated by the fatty acid pattern. Substitution with l-lysine led to a decrease of the molecular area, substitution with d-glucopyranosyl to an increase. On self assembly at 100% relative humidity, all preparations adopted lamellar structures. They showed a high degree of order, in spite of the heterogeneous fatty acid compositions and numerous fatty acid combinations. The repeat distances in lamellar fluid phase varied between 4.99 and 5.52 nm, the bilayer thickness between 3.70 and 4.46 nm. Surprising were the low values of sorbed water per molecule of the glucosyl and lysyl derivatives which were 58 and 60%, compared with those of the respective cardiolipin. When Na+ was replaced as counterion by Ba2+, the bilayer structure was retained, but the lipids were in the lamellar gel phase and the fatty acids were tilted between 32 and 53° away from the bilayer normal. Wide angle X-ray diffraction studies and electron density profiles are also reported. Particular properties of glucosyl cardiolipin are discussed
Reverse hydrotropy by complex formation
Alkylated azacrown ethers lower significantly interfacial tension and are capable of solubilising water-soluble dyes, despite not being able to aggregate in non-polar solvents.</p
Magnetic Proximity Effect in Perovskite Superconductor/Ferromagnet Multilayers
superconducting/ferromagnetic
(SC/FM) multilayers have been studied by neutron reflectometry. Evidence for a
characteristic difference between the structural and magnetic depth profiles is
obtained from the occurrence of a structurally forbidden Bragg peak in the FM
state. The comparison with simulated reflectivity curves allows us to identify
two possible magnetization profiles: a sizable magnetic moment within the SC
layer antiparallel to the one in the FM layer (inverse proximity effect), or a
``dead'' region in the FM layer with zero net magnetic moment. The former
scenario is supported by an anomalous SC-induced enhancement of the
off-specular reflection, which testifies to a strong mutual interaction of SC
and FM order parameters.Comment: 4 pages, 2 figures, submitted to PR
Rising utilization of coronary CT angiography across Europe over the last decade: insights from a large prospective European registry
Abstract
Background/Introduction
The recently updated 2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes endorse the use of coronary computed tomography angiography (CCTA) for exclusion of obstructive coronary artery disease in patients with a low clinical likelihood (Class I, LOE B). Higher demand for CCTA requires broad availability, inevitably involving smaller healthcare providers, such as non-academic hospitals and private practices. Nevertheless, most published data on CCTA image quality and safety rely on exams performed in high-volume academic centers, and little is known about CCTA in non-academic settings.
Purpose
To investigate the utilization of CCTA across Europe over the last decade, focusing on differences between academic and non-academic centers.
Methods
We included patients with stable chest pain and suspected coronary artery disease (CAD) who received CCTA and were included in the European Society of Cardiovascular Radiology MR/CT registry 01/2010–01/2020. We compared CT equipment, image quality, radiation dose, the incidence of periprocedural adverse events, patient characteristics, and CCTA findings between academic (high volume university hospitals) and non-academic centers (non-academic hospitals and private practices).
Results
Overall, 64,317 patients (41.2% women; age 60±13 years) from 212 sites across 19 European countries were included. Academic centers submitted most cases in 2010—2014 (51.6%), whereas non-academic centers accounted for 71.3% of records in 2015–2020. While non-academic centers used less advanced technology, radiation dose remained low (4.54 [interquartile range (IQR) 2.28–6.76] mSv) with a 30% decline of high-dose scans (>7 mSv) over time. Diagnostic image quality was reported in 97.7% of cases, and the rate of acute scan-related events was low (0.4%) (Figure 1). From 2010–2014 to 2015–2020, CCTA nearly doubled in patients with low to intermediate pretest-probability, women >50, and 40–60 years old men (Figure 2). CAD presence and extent decreased slightly over time (prevalence: 2010–2014: 41.5% vs. 2015–2020: 40.6%), (multi-vessel disease in those with CAD: 2010–2014: 61.9% vs. 2015–2020: 55.9%; all p<0.01).
Conclusion
CCTA expands rapidly to non-academic centers across Europe, increasing availability while maintaining relatively low radiation dose, high diagnostic image quality, and safety. Broad availability of high-quality CCTA is essential for a successfully implementation of the recently updated guidelines for the diagnosis and management of chronic coronary syndromes.
Funding Acknowledgement
Type of funding sources: None. Changes in CCTA utilizationChanges in patient characteristic
Impact of Right Atrial Physiology on Heart Failure and Adverse Events after Myocardial Infarction
Background: Right ventricular (RV) function is a known predictor of adverse events in heart failure and following acute myocardial infarction (AMI). While right atrial (RA) involvement is well characterized in pulmonary arterial hypertension, its relative contributions to adverse events following AMI especially in patients with heart failure and congestion need further evaluation. Methods: In this cardiovascular magnetic resonance (CMR)-substudy of AIDA STEMI and TATORT NSTEMI, 1235 AMI patients underwent CMR after primary percutaneous coronary intervention (PCI) in 15 centers across Germany (n = 795 with ST-elevation myocardial infarction and 440 with non-ST-elevation MI). Right atrial (RA) performance was evaluated using CMR myocardial feature tracking (CMR-FT) for the assessment of RA reservoir (total strain εs), conduit (passive strain εe), booster pump function (active strain εa), and associated strain rates (SR) in a blinded core-laboratory. The primary endpoint was the occurrence of major adverse cardiac events (MACE) 12 months post AMI. Results: RA reservoir (εs p = 0.061, SRs p = 0.049) and conduit functions (εe p = 0.006, SRe p = 0.030) were impaired in patients with MACE as opposed to RA booster pump (εa p = 0.579, SRa p = 0.118) and RA volume index (p = 0.866). RA conduit function was associated with the clinical onset of heart failure and MACE independently of RV systolic function and atrial fibrillation (AF) (multivariable analysis hazard ratio 0.95, 95% confidence interval 0.92 to 0.99, p = 0.009), while RV systolic function and AF were not independent prognosticators. Furthermore, RA conduit strain identified low- and high-risk groups within patients with reduced RV systolic function (p = 0.019 on log rank testing). Conclusions: RA impairment is a distinct feature and independent risk factor in patients following AMI and can be easily assessed using CMR-FT-derived quantification of RA strain
Fe and N self-diffusion in amorphous FeN: A SIMS and neutron reflectivity study
Simultaneous measurement of self-diffusion of iron and nitrogen in amorphous
iron nitride (Fe86N14) using secondary ion mass spectroscopy (SIMS) technique
has been done. In addition neutron reflectivity (NR) technique was employed to
study the Fe diffusion in the same compound. The broadening of a tracer layer
of 57Fe8615N14 sandwiched between Fe86N14 layers was observed after isothermal
vacuum annealing of the films at different temperatures in SIMS measurements.
And a decay of the Bragg peak intensity after isothermal annealing was observed
in [Fe86N14/57Fe86N14]10 multilayers in NR. Strong structural relaxation of
diffusion coefficient was observed below the crystallization temperature of the
amorphous phase in both measurements. It was observed from the SIMS
measurements that Fe diffusion was about 2 orders of magnitude smaller compared
to nitrogen at a given temperature. The NR measurements reveal that the
mechanism of Fe self-diffusion is very similar to that in metal-metal type
metallic glasses. The structural relaxation time for Fe and N diffusion was
found comparable indicating that the obtained relaxation time essentially
pertain to the structural relaxation of the amorphous phase.Comment: 10 pages 12 figure
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