ЭКОЛОГИЧЕСКИ ОРИЕНТИРОВАННАЯ ВНЕУРОЧНАЯ ДЕЯТЕЛЬНОСТЬ В ШКОЛЕ: ИННОВАЦИИ И РЕЗУЛЬТАТЫ

The article presents the results of a study of environmentally-oriented extracurricular activities in schools of St. Petersburg: the signs of innovativeness of extracurricular activities are identified; an analysis of the components of ecological culture, the formation of which is largely influenced by extracurricular activities; the prevailing educational technologies and forms of organization of extracurricular activities are given.В статье приведены результаты исследования экологически ориентированной внеурочной деятельности в школах Санкт-Петербурга: определены признаки инновационности внеурочной деятельности; дан анализ компонентов экологической культуры, на формирование которых в большей степени влияет внеурочная деятельность; приведены преобладающие образовательные технологии и формы организации внеурочной деятельности

Information culture of the mass

The significance of the research is determined by the necessity to improve the quality of information culture of the modern society. In this context, the article refers to the "mass" or "the mass person" that has a certain way of thinking and life style which begin dominating under certain conditions. "The mass person" represents a historically arisen and historically passing phenomenon generated by a certain stage of the development of technology. The research is focused upon a brief outline of philosophical and historical stages which have led to the emergence of the “mass person” who strives only for the benefit and achievement of the personal purposes. He obediently accepts ready-made stamps and stereotypes, without caring for their validity. As a result, despite all the talks of individualization, the original identity is lost and replaced with the average, mass person who is going down the stream, turning into a slave of sociality that once again convinces us that "the mass person" is now a phenomenon which arises quite suddenly, but as a result of those substitutions about which we have spoken above. It is that norm which is characteristic of the society constructed on the ideas of pragmatism and usefulness.peer-reviewe

Current and piezoresponse measurements of repolarized regions of thin PbZr54Ti46O3 films

This work was supported by the RFBR grant N 18-32-00092_mol-a

Mycoviruses are common among different species of endophytic fungi of grasses

8 páginas, 1 tabla, 1 figuraA survey of mycoviruses was made in a collection of 103 isolates belonging to 53 different species of endophytic fungi of grasses. DsRNA elements were detected in isolates of 12 of the species analyzed. The banding characteristics and sizes of some of the dsRNA elements suggest that they might belong to previously described mycovirus families. The observed incidence (22.6%) indicates that the presence of mycoviruses could be common among species of this group of ubiquitous fungi.This research was financed by project AGL2005-02839 granted by the Spanish Ministry of Science and Education. We thank Drs. Robert Coutts and Beatríz R. Vázquez de Aldana for reviewing the manuscript.Peer reviewe

Young representatives of ethnic communities: Sociocultural strategies and practices

© 2015, Mediterranean Center of Social and Educational Research. All rights reserved. The article deals with the analysis of the sociocultural identity, linguistic and cultural attitudes, and intragroup solidarity of the young representatives of the Uzbek, Tajik and Azerbaijan people in the Republic of Tatarstan. Religion is considered as an ethnointegrating characteristic, determining and influencing the sociocultural strategies and practices of the diaspora youth. The results presented in the article are based upon the materials obtained by the authors during the period from April to June 2013 on the territory of the Republic of Tatarstan

Effect of powerful pulsed and continuous ion beams on the Al-Cu-Mg alloy structure

The paper considers the results of an electron microscopy study of the VD1 alloy of the Al-Cu-Mg system after cold working and subsequent irradiation with a powerful pulsed ion beam (70% C[+] + 30% H[+], Е=180 keV) in the pulsed-periodic mode ([tau] = 80 ns, f = 0.1 Hz, j = 200 A/cm{2}, F = 1·10{14} cm{-2}) and under the conditions of the generation of only one pulse ([tau] = 180 ns, j = 100 A/cm{2}, F = 2·10{15} cm{-2}). It is established that this irradiation noticeably affects the microstructure of the cold-worked 3 mm thick sheets of VD1 alloy. The initial cellular dislocation structure transforms into a subgrain one. The intensity of structural transformations in the alloy increases with ion current density of a pulse. A similar transformation of a dislocation structure over the entire thickness of the sample is observed under irradiation with continuous Ar{+} ion beams (Е = 20-40 keV) with not high fluences (10{15}-10{16} cm{-2})

Pharmacokinetic Interactions of Phenosanic Acid with Valproic Acid and Carbamazepine in Dogs

Phenosanic acid prevents convulsions, reduces the frequency of epileptic seizures, and improves cognitive, intellectual and mnestic functions in patients with epilepsy. Therefore, phenosanic acid-based medicinal products are promising candidates for inclusion in combination antiepileptic therapy. In order to combine medicinal products rationally and ensure that the therapy is safe, it is useful to study the pharmacokinetic interaction of medicinal products planned for clinical co-administration.The aim of the study was to examine single-dose pharmacokinetic interactions between Dibufelon® 200 mg capsules (PIQ-PHARMA LLC, Russia) and two medicinal products planned for clinical co-application with it, namely, valproic acid and carbamazepine, in sexually mature dogs.Materials and methods: the study included medicinal products of phenosanic acid (Dibufelon® 200 mg capsules by PIQ-PHARMA LLC, Russia), valproic acid (300 mg prolonged-release film-coated tablets), and carbamazepine (200 mg tablets). The medicinal products were administered to beagle dogs (2 groups of 9 males each) as a single oral dose separately and in the following combinations: phenosanic acid with valproic acid and phenosanic acid with carbamazepine. Dose selection involved adjusting maximum human therapeutic doses using interspecies conversion factors. Phenosanic acid was administered at a dose of 24 mg/kg; valproic acid and carbamazepine were administered at a dose of 60 mg/kg. Blood sampling took place at baseline and in 0.5, 0.75, 1, 2, 4, 6, 8, 10, and 24 h after dosing. Plasma concentrations of active substances were determined by HPLC-UV. Pharmacokinetic interactions were evaluated by changes in the main pharmacokinetic parameters (Сmax, Тmax, AUC0-24, MRT, Т1/2).Results: the study demonstrated rapid gastrointestinal absorption and prolonged systemic circulation of phenosanic acid administered separately (Tmax 2–4 h, T1/2 13–28 h) and combined with valproic acid (Tmax 2 h, T1/2 22 h). When administered with carbamazepine, phenosanic acid was eliminated from the systemic blood flow faster (T1/2 7.4 h).Conclusions: co-administration of phenosanic acid and valproic acid medicinal products had no significant effect on their respective pharmacokinetics. Whereas, the combination of phenosanic acid and carbamazepine demonstrated a significant decrease in the Tmax values of phenosanic acid and the MRT values of carbamazepine. The pharmacokinetic changes suggestive of a possible interaction between phenosanic acid and carbamazepine need further clinical investigation

The specificity of psychological protection in the period of remission in patients with cancer

The article defines the concept of psychological protection, describes the specificity of the manifestation of each of the 8 types of protection. The authors gave answers to the following questions - What kind of psychological defense is dominant in people with cancer in remission and in people who do not have this disease? What features have data protection and how manifest in human life?В статье дано развёрнутое определение понятию психологической защиты, описана специфика проявления каждой из 8 типов защит. Авторы дают ответы на следующие вопросы: Какая психологическая защита является доминирующей у людей с онкологическими заболеваниями в стадии ремиссии и у людей, не имеющих данное заболевание? Какие особенности имеют данные защиты и как проявляются в жизни человека

ОПЫТ ЛЕЧЕНИЯ ЛИМФОМЫ ХОДЖКИНА РЕФРАКТЕРНОГО ТЕЧЕНИЯ

Background. The use of modern induction chemotherapy programs for primary Hodgkin’s lymphoma allows achievement of high long-term outcomes even in patients with initially poor prognosis. However, the toxicity of treatment is quite high. Despite the effectiveness of chemotherapy, the frequency of relapses and resistant forms varies from 20 to 30 %. In extremely rare cases, the use of intensive chemotherapy regimens, including high-dose chemotherapy, leads to long-term remissions.Description of the clinical case. We present a case of advanced-stage Hodgkin’s lymphoma in a young patient with symptoms of intoxication and adverse risk factors, such as: massive lesion in the mediastinum, increased ES R, infiltration of soft tissues, pleura, pericardium, multiple lesions of both lungs, damage to more than 3 areas of the lymphatic collectors. Given all these factors, the disease prognosis was extremely unfavorable, with a low probability of achieving remission and a high risk of early progression. The use of the intensive EACOPP -14 program allowed the achievement of short-term partial remission. Due to poor treatment tolerance, but taking into account the achievement of a partial response, further treatment was continued using the ABVD chemotherapy regimen. Follow-up examination revealed disease progression. Further courses of chemotherapy using various combinations of chemotherapy drugs resulted in a short-term positive effect with subsequent disease progression. Considering the fact that the disease was resistant to most basic chemotherapeutic agents, immunotherapy with nivolumab (PD -1 inhibitor) was administered. This alternative treatment method allowed the disease to be stabilized.Conclusion. The use of the immunological drug in a patient with chemoresistant Hodgkin’s lymphoma made it possible to stop the progression of the disease and to improve the patient’s quality of life, without significant infectious complications and adverse events.Актуальность. Использование современных программ индукционной химиотерапии при первичной лимфоме Ходжкина позволяет достичь высоких долгосрочных результатов даже у пациентов с исходно неблагоприятным прогнозом. При этом токсичность лечения достаточно высока. Несмотря на эффективность химиотерапии, частота рецидивов и  резистентных форм варьирует от 20 до 30 %. Достижение длительных ремиссий заболевания у части этих пациентов даже с помощью интенсивных режимов химиотерапии, включая высокодозную химиотерапию, крайне затруднительно. Описание клинического случая. Представлен опыт лечения лимфомы Ходжкина у молодой пациентки с распространенной стадией заболевания. В дебюте заболевания определялись симптомы интоксикации и неблагоприятные факторы риска: массивное  образование в средостении, повышенное СОЭ, инфильтрация мягких тканей, плевры, перикарда, множественное поражение обоих легких, поражение более 3 областей лимфатических коллекторов. С учетом всех данных прогноз заболевания был  крайне неблагоприятным с низкой вероятностью достижения ремиссии и высоким  риском раннего прогрессирования. Использование индукционной химиотерапии по интенсифицированной программе «eacopp-14» позволило достичь кратковременной частичной ремиссии. В связи с крайне тяжелой переносимостью лечения и в то же  время с учетом достижения частичного эффекта лечение было продолжено по схеме «aBVd». При очередном промежуточном обследовании констатировано  прогрессирование заболевания. В дальнейшем пациентке суммарно проведено множество курсов химиотерапии с использованием различных сочетаний  химиопрепаратов с кратковременным положительным эффектом и последующим прогрессированием заболевания. Принимая во внимание резистентное к большинству базисных химиопрепаратов течение заболевания, в качестве  альтернативного метода использована иммунотерапия ингибитором pd-1 ниволумабом, которая позволила стабилизировать заболевание.Заключение. Применение лекарственного препарата иммунологической  направленности у пациентки с химиорезистентным течением лимфомы Ходжкина позволило остановить прогрессирование заболевания, улучшить качество жизни  больной без значимых инфекционных осложнений и нежелательных явлений, связанных с применением препарата