Parameters of the Transmembrane Transport of Pelophylax ridibundus in the Conditions of Thermal Reservoirs

Study of Pelophylax ridibundus skin physiological parameters in a thermal basin shows that there are seasonal differences in PD (potential difference) and ISC (active transportation parameter). Amphibians studied in the summer time in a control area showed some differences compared to specimens caught in summer time in abasin with higher temperatures (River Malaya Kushva). We may suppose that this is connected with the habitation adaptation of the population

VARIABILITY OF A SKELETON AND ANOMALIES OF JUVENILIES SIBERIAN FROG (RANA AMURENSIS)

The work represents analysis of deviations in skeleton variability of siberian frog – Rana amurensis juveniles. It was found that anomalies of axial skeleton predominate in sample under investigation. These results are differing from other three frog's species inhabiting Middle Urals by spectrum and frequency.В работе преставлен анализ вариантов скелетных аномалий сеголеток сибирской лягушки – Rana amurensis. Установлено, что в исследуемой выборке преобладают аномалии осевого скелета. Полученные результаты отличаются по спектру и частоте от данных по трем другим видам лягушек, населяющих Средний Урал

Generation of small-scale structures in the developed turbulence

The Navier-Stokes equation for incompressible liquid is considered in the limit of infinitely large Reynolds number. It is assumed that the flow instability leads to generation of steady-state large-scale pulsations. The excitation and evolution of the small-scale turbulence is investigated. It is shown that the developed small-scale pulsations are intermittent. The maximal amplitude of the vorticity fluctuations is reached along the vortex filaments. Basing on the obtained solution, the pair correlation function in the limit $r\to 0$ is calculated. It is shown that the function obeys the Kolmogorov law $r^{2/3}$.Comment: 18 page

Thermodynamic aspects of materials' hardness: prediction of novel superhard high-pressure phases

In the present work we have proposed the method that allows one to easily estimate hardness and bulk modulus of known or hypothetical solid phases from the data on Gibbs energy of atomization of the elements and corresponding covalent radii. It has been shown that hardness and bulk moduli of compounds strongly correlate with their thermodynamic and structural properties. The proposed method may be used for a large number of compounds with various types of chemical bonding and structures; moreover, the temperature dependence of hardness may be calculated, that has been performed for diamond and cubic boron nitride. The correctness of this approach has been shown for the recently synthesized superhard diamond-like BC5. It has been predicted that the hypothetical forms of B2O3, diamond-like boron, BCx and COx, which could be synthesized at high pressures and temperatures, should have extreme hardness

Manifestation of systemic toxicity in rats after a short-time inhalation of lead oxide nanoparticles

Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism’s status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension’s development). © 2020 by the authors. Licensee MDPI, Basel, Switzerland.Funding: This work was funded by the budget of the Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Genetic markers of Munc13 protein family member, BAIAP3, are gender-specifically associated with anxiety and benzodiazepine abuse in mouse and man

Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together. Unfortunately, treatment of anxiety disorders still includes benzodiazepines, and patients with an existing comorbid benzodiazepine use disorder or a genetic susceptibility for benzodiazepine use disorder may be at risk of adverse treatment outcomes. The identification of genetic predictors for anxiety disorders, and especially for benzodiazepine use disorder, could aid the selection of the best treatment option and improve clinical outcomes. The brain-specific angiogenesis inhibitor I–associated protein 3 (Baiap3) is a member of the mammalian uncoordinated 13 (Munc13) protein family of synaptic regulators of neurotransmitter exocytosis, with a striking expression pattern in amygdalae, hypothalamus and periaqueductal gray. Deletion of Baiap3 in mice leads to enhanced seizure propensity and increased anxiety, with the latter being more pronounced in female than in male animals. We hypothesized that genetic variation in human BAIAP3 may also be associated with anxiety. By using a phenotype-based genetic association study, we identified two human BAIAP3 single-nucleotide polymorphism risk genotypes (AA for rs2235632, TT for rs1132358) that show a significant association with anxiety in women and, surprisingly, with benzodiazepine abuse in men. Returning to mice, we found that male, but not female, Baiap3 knockout (KO) mice develop tolerance to diazepam more quickly than control animals. Analysis of cultured Baiap3 KO hypothalamus slices revealed an increase in basal network activity and an altered response to diazepam withdrawal. Thus, Baiap3/BAIAP3 is gender specifically associated with anxiety and benzodiazepine use disorder, and the analysis of Baiap3/BAIAP3-related functions may help elucidate mechanisms underlying the development of both disorders

A Multi-Model Paradigm in Application to the Analysis of the Factors Defining the Epizootic Situation in the Communities of Non-Synanthropic Small Mammals in Ekaterinburg

The aim of the work was to rank statistical models for assessing the contribution of a number of factors that determine the epizootic situation on natural-focal infectious diseases in the communities of non-synanthropic small mammals (SM) in the forests of Ekaterinburg.Materials and methods. The SM survey was carried out for three years in the summer-autumn period. The animals were caught with snap tpaps on a standard bread bait, 9705 trap-nights were worked out. To identify infections (hemorrhagic fever with renal syndrome, tularemia, leptospirosis, yersiniosis, pseudotuberculosis), 333 SM specimens (rodents and shrews of six species) were used, randomly taken from the general sample. To determine the pathogens, the methods of enzyme immunoassay and polymerase chain reaction were used. The cumulative infection rate of small mammals with all studied natural-focal infections was evaluated. Statistical data processing was carried out from the standpoint of a multi-model approach. The selection of models was performed using the Akaike information criterion with the calculation of the sum of the weights of the models based on their full spectrum (SW).Results and discussion. Carriers of all of the mentioned above infections, except for pseudotuberculosis, have been identified in the forest parks of Ekaterinburg. According to the ranking, the model with three predictors received the highest weight: species, year, and the abundance of SM of the previous year in a particular habitat. The most significant predictors for the full spectrum of models are the year (SW=1), species (SW=0.6), abundance of animals in the current and previous year (SW=0.48). The distribution of positive samples by species of small mammals corresponded to their ranking by abundance in the community. The influence of the factors “season” (summer or autumn) and “area” (place of capture of animals) turned out to be insignificant on the scale of the studies (SW = 0.3 and 0.16, respectively). The percentage of infected samples in total for all infections varied significantly by location and year (0–60%). The possible significance of unaccounted factors is discussed: landscape features and the mode of using forest parks, dispersal of small mammals. The conclusion is made about the usefulness of the multi-model approach in the analysis of the data from epizootiological studies

Pressure balance in the multiphase ISM of cosmologically simulated disc galaxies

Pressure balance plays a central role in models of the interstellar medium (ISM), but whether and how pressure balance is realized in a realistic multiphase ISM is not yet well understood. We address this question by using a set of FIRE-2 cosmological zoom-in simulations of Milky Way-mass disc galaxies, in which a multiphase ISM is self-consistently shaped by gravity, cooling, and stellar feedback. We analyse how gravity determines the vertical pressure profile as well as how the total ISM pressure is partitioned between different phases and components (thermal, dispersion/turbulence, and bulk flows). We show that, on average and consistent with previous more idealized simulations, the total ISM pressure balances the weight of the overlying gas. Deviations from vertical pressure balance increase with increasing galactocentric radius and with decreasing averaging scale. The different phases are in rough total pressure equilibrium with one another, but with large deviations from thermal pressure equilibrium owing to kinetic support in the cold and warm phases, which dominate the total pressure near the mid-plane. Bulk flows (e.g. inflows and fountains) are important at a few disc scale heights, while thermal pressure from hot gas dominates at larger heights. Overall, the total mid-plane pressure is well-predicted by the weight of the disc gas and we show that it also scales linearly with the star formation rate surface density (ςSFR). These results support the notion that the Kennicutt-Schmidt relation arises because ςSFR and the gas surface density (ςg) are connected via the ISM mid-plane pressure

A novel accessory muscle in the flexor compartment of anterior forearm inserting into the tenosynovium of the flexor pollicis longus

A common variant of accessory muscles in the anterior forearm is the Gantzer’s muscle (GM). GM arises as a muscle belly from flexor digitorum superficialis (FDS) or ulnar coronoid process to merge distally with the flexor pollicis longus (FPL) muscle. In the present case report, we describe a novel accessory muscle in the flexor compartment of the forearm. The proximal attachment was tendinous and came from three sources: FDS muscle, ulnar coronoid process, and the medial aspect of the proximal radius. The distal tendon of the novel accessory muscle ran parallel to FPL, passed through the carpal tunnel, and entered the palmar aspect of the hand. In the hand, the tendon thinned out and blended with the tenosynovium of the FPL, contributing to the sheath around the FPL tendon. This accessory muscle of the FPL is comparable to the frequently documented Gantzer muscle (GM); however, the present case exhibited fundamental nuances that distinguish it from the previously described iterations of the GM in the following ways: 1) The novel accessory muscle is tendinous from its proximal origin and throughout the upper one-third of the forearm, and one component of its origin arose from the medial aspect of the radius. Gantzer muscles with an origin on the radius have not been previously reported. 2) In the middle one-third, the tendinous proximal attachment transitioned to a muscle belly that passed through the carpal tunnel and entered the hand. 3) In the hand, the novel tendon widened, thinned, and merged with the tenosynovium of the FPL. Accessory muscles are a common finding in the anterior forearm during cadaveric dissection. In patients, they can be the cause of neuropathies due to compression of the anterior interosseous nerve. Awareness of variations is also important for clinicians who examine the forearm and hand, as well as hand and surgeons

INFLUENCE EXERTED BY SOMATIC PATHOLOGY ON RISKS OF OCCUPATIONAL LUNG FIBROSIS IN WORKERS EMPLOYED AT REFRACTORY PRODUCTION

Occupational lungs and bronchial pathology occurs not only under exposure to dusts, their aerosol structure and aggression, but also depends on individual properties of a body. The latter can determine either increased body resistance or susceptibility to occupational pathology occurrence. Our research goal was to determine influence exerted by somatic pathology on occupational lung fibrosis occurrence as well as to estimate prevalence of risk factors for cardiovascular and metabolic pathology occurrence in workers employed at refractory production. At the first stage 449 workers employed at refractory production were examined at a periodical medical examination (PME). Patients' average age was 41.59 ± 0.45 and average work experience was 14.47 ± 0.39 years. At the second stage 172 workers were examined at an occupational pathology center; 75 out of them were workers who had silicosis and were included into the test group and the remaining 97 workers didn't have any occupational pathology and were included into the reference group. Both groups were comparable as per sex (p = 0.0052) and work experience under exposure to dusts (p = 0.862). Workers examined at a PME most frequently had overweight and obesity (68 %). Arterial hypertension (AH) prevalence amounted to 19.5%; carbohydrate metabolism disorders, 19.8 %; 48.1 % workers had hypercholesterolemia. Patients with silicosis had certain disorders significantly more frequently than workers with long work experience but without any occupational pathologies; those disorders were AH, cardiac muscle hypertrophy in the left ventricle, ischemic heart disease, heart rate disorders, as well as mixed (obstructive and restrictive) breath mechanics disorders. We determined some factors that authentically produced certain effects on occupational lung fibrosis occurrence in workers employed at refractory production. Median time of silicosis occurrence was significantly shorter (by 11.5 years) among workers with severe AH, arrhythmia (by 13 years), lower hemoglobin in blood (by 11.5 years). Besides, silicosis occurred significantly earlier (by 10.8) among women than among men. © 2020 Obukhova T.Yu., Budkar' L.N., Gurvich V.B., Solodushkin S.I., Shmonina O.G., Karpova E.A.,. All Rights Reserved