Zero field spin splitting in AlSb/InAs/AlSb quantum wells induced by surface proximity effects

InAs quantum well heterostructures are of considerable interest for mesoscopic device applications such as scanning probe and magnetic recording sensors, which require the channel to be close to the surface. Here we report on magnetotransport measurements of AlSb/InAs/AlSb Hall bars at a shallow depth of 20 nm. Analysis of the observed Shubnikov-de Haas oscillations and modeling show that spin splitting energies in excess of 2.3 meV occur at zero magnetic field. We conclude that the spin-splitting results from the Rashba effect due to the band bending in the quantum well. This is caused by substantial electron transfer from the surface to the quantum well and becomes significant when the quantum well is located near the surface.Comment: 14 pages, 2 figures. (To be published in APL

Estimating water flow through a hillslope using the massively parallel processor

A new two-dimensional model of water flow in a hillslope has been implemented on the Massively Parallel Processor at the Goddard Space Flight Center. Flow in the soil both in the saturated and unsaturated zones, evaporation and overland flow are all modelled, and the rainfall rates are allowed to vary spatially. Previous models of this type had always been very limited computationally. This model takes less than a minute to model all the components of the hillslope water flow for a day. The model can now be used in sensitivity studies to specify which measurements should be taken and how accurate they should be to describe such flows for environmental studies

Programming a hillslope water movement model on the MPP

A physically based numerical model was developed of heat and moisture flow within a hillslope on a parallel architecture computer, as a precursor to a model of a complete catchment. Moisture flow within a catchment includes evaporation, overland flow, flow in unsaturated soil, and flow in saturated soil. Because of the empirical evidence that moisture flow in unsaturated soil is mainly in the vertical direction, flow in the unsaturated zone can be modeled as a series of one dimensional columns. This initial version of the hillslope model includes evaporation and a single column of one dimensional unsaturated zone flow. This case has already been solved on an IBM 3081 computer and is now being applied to the massively parallel processor architecture so as to make the extension to the one dimensional case easier and to check the problems and benefits of using a parallel architecture machine

Structural basis for the design of selective phosphodiesterase 4B inhibitors

AbstractPhosphodiesterase-4B (PDE4B) regulates the pro-inflammatory Toll Receptor –Tumor Necrosis Factor α (TNFα) pathway in monocytes, macrophages and microglial cells. As such, it is an important, although under-exploited molecular target for anti-inflammatory drugs. This is due in part to the difficulty of developing selective PDE4B inhibitors as the amino acid sequence of the PDE4 active site is identical in all PDE4 subtypes (PDE4A-D). We show that highly selective PDE4B inhibitors can be designed by exploiting sequence differences outside the active site. Specifically, PDE4B selectivity can be achieved by capture of a C-terminal regulatory helix, now termed CR3 (Control Region 3), across the active site in a conformation that closes access by cAMP. PDE4B selectivity is driven by a single amino acid polymorphism in CR3 (Leu674 in PDE4B1 versus Gln594 in PDE4D). The reciprocal mutations in PDE4B and PDE4D cause a 70–80 fold shift in selectivity. Our structural studies show that CR3 is flexible and can adopt multiple orientations and multiple registries in the closed conformation. The new co-crystal structure with bound ligand provides a guide map for the design of PDE4B selective anti-inflammatory drugs

Homeownership and effectiveness of the South Africa government housing subsidy scheme

This paper presents findings on the effectiveness of the South Africa government housing subsidy scheme in the delivery of houses to its citizens, thus providing homeownership especially to the low-income group and the disadvantaged poor. The paper also evaluates the usage of the houses by the occupants. The results from the post-occupancy survey of the provided houses revealed that the progressive realization of housing for the low-income and disadvantaged groups is being met as all beneficiaries were South African citizens. The survey also revealed that the beneficiaries living in the subsidized houses were originally allocated the houses by the Gauteng Department of Housing (GDOH), which oversees housing allocation in the province adopted as the site for the study. However, from those originally allocated, it was indicated that some of the beneficiaries were previously living in shacks, while some were homeless (absolute homelessness). Further findings from the survey showed that the original intended use of the houses by the government (private residential use) is what the subsidized houses are being used for as revealed by the respondents. This paper starts with an overview of the literature on this topic and the importance of homeownership, and then presents the results of the analysis and findings of the research. Finally, the paper draws some conclusions and makes recommendations. The originality of this paper is based on the fact that there have been issues surrounding the South Africa government's financial commitment of 5% of its Gross Domestic Product (GDP) is grossly inadequate to overcome its huge housing backlog. Due to the limited study to substantiate if the little devoted GDP is making any impact on the disadvantaged group, the current research contributes to this body of knowledge

Advancing procedural justice in conservation

Just participation in conservation decision-making is a moral imperative and critical to achieving social and ecological goals. However, understanding of what constitutes a just decision-making process in conservation remains limited. Integrating key literature from environmental justice, psychology of justice, and participatory conservation, we identify 11 procedural justice criteria, many of which have been overlooked in conservation literature. We develop a framework to help promote procedural justice in conservation decision-making which organizes the criteria into three key domains (Process properties, Agency of participants, Interpersonal treatment), which are underpinned by the justice dimension of recognition. We highlight seven policy levers that can be used to enhance procedural justice (e.g., scalar and contextual fit, conflict resolution, facilitation). However, advancing just decision-making using this framework requires addressing a number of key challenges, in particular those related to broader structural power inequalities, and elucidating and accounting for plural and situated conceptions of procedural justice. We outline a number of pathways to overcome these challenges, including promoting knowledge coproduction and self-reflexivity

Genetic Association of Phosphodiesterases With Human Cognitive Performance

Recent, large-scale, genome-wide association studies (GWAS) provide a first view of the genetic fine structure of cognitive performance in healthy individuals. These studies have pooled data from up to 1.1 million subjects based on simple measures of cognitive performance including educational attainment, self-reported math ability, highest math class taken, and pooled, normalized scores from cognitive tests. These studies now allow the genome-wide interrogation of genes and pathways for their potential impact on human cognitive performance. The phosphodiesterase (PDE) enzymes regulate key cyclic nucleotide signaling pathways. Many are expressed in the brain and have been the targets of CNS drug discovery. Genetic variation in PDE1C, PDE4B and PDE4D associates with multiple measures of human cognitive function. The large size of the human PDE4B and PDE4D genes allows genetic fine structure mapping to transcripts encoding dimeric (long) forms of the enzymes. Upstream and downstream effectors of the cAMP pathway modulated by PDE4D [adenylate cyclase 1 (ADCY1), ADCY8, PRKAR1A, CREB1, or CREBBP] did not show genetic association with cognitive performance, however, genetic association was seen with brain derived neurotrophic factor (BDNF), a gene whose expression is modulated by cAMP. Notably absent was genetic association in healthy subjects to targets of CNS drug discovery designed to improve cognition in disease states by the modulation of cholinergic [acetylcholinesterase (ACHE), choline acetyltransferase (CHAT), nicotinic alpha 7 acetylcholine receptor (CHRNA7)], serotonergic (HTR6), histaminergic (HRH3), or glutamatergic (GRM5) pathways. These new data provide a rationale for exploring the therapeutic benefit of selective inhibitors of PDE1C, PDE4B and PDE4D in CNS disorders affecting cognition

A Model for an Angular Velocity-Tuned Motion Detector Accounting for Deviations in the Corridor-Centering Response of the Bee

We present a novel neurally based model for estimating angular velocity (AV) in the bee brain, capable of quantitatively reproducing experimental observations of visual odometry and corridor-centering in free-flying honeybees, including previously unaccounted for manipulations of behaviour. The model is fitted using electrophysiological data, and tested using behavioural data. Based on our model we suggest that the AV response can be considered as an evolutionary extension to the optomotor response. The detector is tested behaviourally in silico with the corridor-centering paradigm, where bees navigate down a corridor with gratings (square wave or sinusoidal) on the walls. When combined with an existing flight control algorithm the detector reproduces the invariance of the average flight path to the spatial frequency and contrast of the gratings, including deviations from perfect centering behaviour as found in the real bee's behaviour. In addition, the summed response of the detector to a unit distance movement along the corridor is constant for a large range of grating spatial frequencies, demonstrating that the detector can be used as a visual odometer