2-[3-(1H-Benzimidazol-2-yl)prop­yl]-1H-benzimidazol-3-ium 3,5-dicarb­oxy­benzoate–benzene-1,3,5-tricarb­oxy­lic acid–water (1/1/1)

The title compound, C17H17N4 +·C9H5O6 −·C9H6O6·H2O, contains a protonated 2,2′-(1,3-propanedi­yl)bis­(1H-benzimidazole) cation, a deprotonated benzene-1,3,5-tricarb­oxy­lic acid anion, a neutral benzene-1,3,5-tricarb­oxy­lic acid mol­ecule and a water mol­ecule, which are linked together through N—H⋯O, O—H⋯O and weak C—H⋯O hydrogen bonds into almost double sheets parallel to (4 ). These hydrogen-bonded sheets are packed in the crystal with the formation of centrosymmetric voids of 25.5 Å3, which are filled by the water mol­ecules

The Evaluation of E-commerce Efficiency in China using DEA-Tobit model: evidence from Taobao data

Using the analytical framework of DEA-Tobit, this paper investigates the efficiency of e-commerce in China\u27s provinces based on the cross-section data of 31 provinces in China and the data of e-commerce service providers from Taobao’s open platform. The data envelopment analysis (DEA) is used to calculate the technical efficiency and scale efficiency. Furthermore the paper gives an empirical test on the relationship between the scale efficiency and influencing factors by using the censored Tobit model. The results show there are significant regional differences in the efficiency of e-commerce services in provinces of China, and the Real GDP per capita, the seller number on e-commerce platform, the retail sales and wholesale are important reasons for the different efficiency in each province of China. This study provides a domain-specific, integrative approach in evaluating the E-commerce development combining macro data from National Bureau of Statistics of China and micro data from taobao.com

A Lifting Relation from Macroscopic Variables to Mesoscopic Variables in Lattice Boltzmann Method: Derivation, Numerical Assessments and Coupling Computations Validation

In this paper, analytic relations between the macroscopic variables and the mesoscopic variables are derived for lattice Boltzmann methods (LBM). The analytic relations are achieved by two different methods for the exchange from velocity fields of finite-type methods to the single particle distribution functions of LBM. The numerical errors of reconstructing the single particle distribution functions and the non-equilibrium distribution function by macroscopic fields are investigated. Results show that their accuracy is better than the existing ones. The proposed reconstruction operator has been used to implement the coupling computations of LBM and macro-numerical methods of FVM. The lid-driven cavity flow is chosen to carry out the coupling computations based on the numerical strategies of domain decomposition methods (DDM). The numerical results show that the proposed lifting relations are accurate and robust

The Beixin Culture archaeobotanical evidence from Guanqiaocunnan indicates a population dispersal of hunter-gatherercultivators into and across the Haida region of northern China

The Beixin Culture appears within the hilly southwestern area of the Haidai region of northern China at ca. 5000 BC, and spreads to its north and northeast flood plains in the following millennium, replacing the Houli Culture. Does the Beixin Culture represent a further example of recently established farmers dispersing into a new territory, in this case being dependent on millet farming and coming from the Huai River Valley? We test this hypothesis by analysing and interpreting the archaeobotanical remains from Guanqiaocunnan, 4340-3970 BC. We conclude that the Beixin Culture represents the dispersal of hunter-gatherers/cultivators rather than farmers

Stochastic bifurcation characteristics of cantilevered piezoelectric energy harvester

Stochastic bifurcation characteristics of cantilevered piezoelectric energy harvester were studied in this paper. Von de Pol differencial item was introduced to interpret the hysteretic phenomena of piezoelectric ceramics, and then the nonlinear dynamic model of piezoelectric cantilever beam subjected to axial stochastic excitation was developed. The stochastic stability of the system was analyzed, and the steady-state probability density function and the joint probability density function of the dynamic response of the system were obtained, and then the conditions of stochastic Hopf bifurcation were analyzed. Numerical simulation shows that stochastic Hopf bifurcation appears when bifurcation parameter varies, which can increase vibration amplitude of cantilever beam system and improve the efficiency of piezoelectric energy harvester. Finally, the theoretical and numerical results were proved by experiments. The results of this paper are helpful to application of cantilevered piezoelectric energy harvester in engineering fields

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis.

BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). While inactivation of dynamin-related protein 1 (Drp1), a GTPase that regulates mitochondrial fission, can reduce EAE severity by protecting myelin from demyelination, its effect on immune responses in EAE has not yet been studied. METHODS: We investigated the effect of Mdivi-1, a small molecule inhibitor of Drp1, on EAE. Clinical scores, inflammation, demyelination and Drp1 activation in the central nervous system (CNS), and T cell responses in both CNS and periphery were determined. RESULTS: Mdivi-1 effectively suppressed EAE severity by reducing demyelination and cellular infiltration in the CNS. Mdivi-1 treatment decreased the phosphorylation of Drp1 (ser616) on CD4+ T cells, reduced the numbers of Th1 and Th17 cells, and increased Foxp3+ regulatory T cells in the CNS. Moreover, Mdivi-1 treatment effectively inhibited IFN-γ+, IL-17+, and GM-CSF+ CD4+ T cells, while it induced CD4+ Foxp3+ regulatory T cells in splenocytes by flow cytometry. CONCLUSIONS: Together, our results demonstrate that Mdivi-1 has therapeutic potential in EAE by modulating the balance between Th1/Th17 and regulatory T cells

2-Amino-6-(naphthalen-1-yl)-4-phenyl­pyridine-3-carbonitrile

In the title compound, C22H15N3, the naphthyl ring system makes dihedral angles of 67.40 (2) and 59.80 (3)° with the pyridyl and phenyl rings, respectively. In the crystal, the mol­ecules are connected via inter­molecular N—H⋯N hydrogen bonds, forming a three-dimensional network

1-{(1Z)-1-[3-(2,4-Dichloro­phen­oxy)prop­oxy]-1-(2,4-difluoro­phen­yl)prop-1-en-2-yl}-1H-1,2,4-triazole

In the title compound, C20H17Cl2F2N3O2, the triazole ring makes dihedral angles of 28.0 (3) and 72.5 (2)° with the 2,4-dichloro­pheny and 2,4-difluoro­phenyl rings, respectively, and the mol­ecule adopts a Z-conformation about the C=C double bond. In the crystal, C—H⋯O and C—H⋯N hydrogen bonds link the mol­ecules