Das deutsche Streben nach einem ständigen Sitz im UN-Sicherheitsrat : Analyse eines Irrwegs und Skizzen eines Auswegs

Diese Studie analysiert die deutsche UN-Reformpolitik der letzten Jahre. Im Mittelpunkt steht eine kritische Auseinandersetzung mit der politischen Zielsetzung, einen nationalen ständigen Sitz für Deutschland im Sicherheitsrat der Vereinten Nationen zu erlangen. Vor dem Hintergrund prominenter Vorschläge zur Reform des Sicherheitsrats wird zunächst die Genese dieses Anspruchs rekonstruiert. In einem weiteren Schritt werden die Positionen wichtiger Verbündeter und Partner untersucht. Dabei wird deutlich, wie wenig Unterstützung Deutschland selbst von seinen wichtigsten Partnern erfährt und wie sehr diese Unterstützung in den letzten Jahren abgenommen hat. Die anschließende Analyse der wichtigsten Argumente für einen ständigen deutschen Sitz zeigt, dass sie einer kritischen Prüfung nicht Stand halten können. Die Studie schließt mit einem Plädoyer und konkreten Vorschlägen für eine Wiederbelebung einer europäischen Option.This paper examines Germany´s policy vis-à-vis UN reform. It focuses in particular on Germany´s goal to secure a permanent seat at the Security Council. Against the background of prominent reform proposals the paper first recounts the evolution of the federal government´s position. It then examines the responses of prominent allies and partners. This analysis reveals that support for Germany´s claim is not only far weaker than usually suggested but also in steady decline. A closer look at the arguments put forth in support of Germany´s claim for a permanent seat shows that few can really stand up to scrutiny. The study closes with a plea for a resuscitation of a European option for UN reform

Transcatheter closure of atrial septal defects within the oval fossa: medium-term results in children using the ‘ASDOS'-technique

Abstract Objectives The purpose of this study was to evaluate the safety and efficacy of the ASDOS-tech-nique (Sulzer-Osypka GmbH, Germany) for transcatheter closure of atrial septal defects within the oval fossa. Background Although several attempts have been made to occlude defects within the oval fossa by transcatheter techniques, none of these has gained general acceptance. Methods Patients with a defect in the oval fossa measuring equal to or less than 20 mm diameter, with a residual septal rim of 5mm or greater, body weight greater than 10 kg, with clinical indications for surgical closure were considered for transcatheter closure. Follow-up investigations were performed at discharge, after 1, 3, 6 and 9 months, as well as after 1 and 2 years. Results Of 78 patients considered for closure, a device was inserted in 41 patients (53%), with success being achieved in 40 patients (98%). The ages ranged from 1.1 to 15 years (7.8 ± 1.92 years), the 'stretched' diameter of the defect from 10 to 20 mm (14.7 ± 2.60 mm), and the diameters of the inserted devices from 25 to 45 mm (33.2 ± 5.43 mm). Transient impairment of atrioventricular conduction occured in 4 patients. During the follow-up of 23.0 ± 5.6 months elective surgical closure of a residual shunt was performed 26 months after insertion of the devcie in one patient. None of the other patients required surgery, hospitalisation or medical treatment, and none is requiring further treatment of the defect within the oval fossa. Fracture of one arm of the device occurred in 4 patients, but the fractured arms are in an unchanged and stable position after a period of at least 19 months. Conclusions Our medium-term data show that transcatheter closure in children of defects within the oval fossa can be performed with a high efficacy and safety using the ASDOS-devic

Superparamagnetic relaxation in Cu_{x}Fe_{3-x}O_{4} (x=0.5 and x=1) nanoparticles

The scope of this article is to report very detailed results of the measurements of magnetic relaxation phenomena in the new Cu$_{0.5}$Fe$_{2.5}$O$_{4}$ nanoparticles and known CuFe$_{2}$O$_{4}$ nanoparticles. The size of synthesized particles is (6.5$\pm$1.5)nm. Both samples show the superparamagnetic behaviour, with the well-defined phenomena of blocking of magnetic moment. This includes the splitting of zero-field-cooled and field-cooled magnetic moment curves, dynamical hysteresis, slow quasi-logarithmic relaxation of magnetic moment below blocking temperature. The scaling of the magnetic moment relaxation data at different temperatures confirms the applicability of the simple thermal relaxation model. The two copper-ferrites with similar structures show significantly different magnetic anisotropy density and other magnetic properties. Investigated systems exhibit the consistency of all obtained results.Comment: 18 pages, 8 figure

Malonate as a ROS product is associated with pyruvate carboxylase activity in Acute Myeloid Leukaemia cells

BACKGROUND: The role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer. Here, we use a tracer-based NMR analysis involving high-resolution (1)H-(13)C-HSQC spectra to assess site-specific label incorporation into a range of metabolite pools, including malate, aspartate and glutamate in the acute myeloid leukaemia cell line K562. We also determine how this is affected following treatment with the redeployed drug combination of the lipid-regulating drug bezafibrate and medroxyprogesterone (BaP). RESULTS: Using the tracer-based approach, we assessed the contribution of pyruvate carboxylase (PC) vs. pyruvate dehydrogenase (PDH) activity in the derivation of Krebs cycle intermediates. Our data show that PC activity is indeed high in K562 cells. We also demonstrate a branched entry to the Krebs cycle of K562 cells with one branch running counterclockwise using PC-derived oxaloacetate and the other clockwise from the PDH activity. Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate. CONCLUSIONS: This study extends the interest in the PC activity in solid cancers to include leukaemias and further demonstrates the value of tracer-based NMR approaches in generating a more accurate picture of the flow of carbons and metabolites within the increasingly inappropriately named Krebs cycle. Moreover, our studies indicate that the PC activity in cancer cells can be exploited as an Achilles heel by using treatments, such as BaP, that elevate ROS production. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40170-016-0155-7) contains supplementary material, which is available to authorized users

The Hot QCD White Paper: Exploring the Phases of QCD at RHIC and the LHC

The past decade has seen huge advances in experimental measurements made in heavy ion collisions at the Relativistic Heavy Ion Collider (RHIC) and more recently at the Large Hadron Collider (LHC). These new data, in combination with theoretical advances from calculations made in a variety of frameworks, have led to a broad and deep knowledge of the properties of thermal QCD matter. Increasingly quantitative descriptions of the quark-gluon plasma (QGP) created in these collisions have established that the QGP is a strongly coupled liquid with the lowest value of specific viscosity ever measured. However, much remains to be learned about the precise nature of the initial state from which this liquid forms, how its properties vary across its phase diagram and how, at a microscopic level, the collective properties of this liquid emerge from the interactions among the individual quarks and gluons that must be visible if the liquid is probed with sufficiently high resolution. This white paper, prepared by the Hot QCD Writing Group as part of the U.S. Long Range Plan for Nuclear Physics, reviews the recent progress in the field of hot QCD and outlines the scientific opportunities in the next decade for resolving the outstanding issues in the field.Comment: 110 pages, 33 figures, 429 references. Prepared as part of the U.S. Long-Range Plan for Nuclear Physic

Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia

Background: The majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also those younger patients who relapse, remain dismal and novel therapies are urgently required. In particular, therapies that have anti-leukaemic activity but that, unlike conventional chemotherapy, do not impair normal haemopoiesis. Principal Findings: Here we demonstrate the potent anti-leukaemic activity of the combination of the lipid-regulating drug bezafibrate (BEZ) and the sex hormone medroxyprogesterone acetate (MPA) against AML cell lines and primary AML cells. The combined activity of BEZ and MPA (B/M) converged upon the increased synthesis and reduced metabolism of prostaglandin D2 (PGD2) resulting in elevated levels of the downstream highly bioactive, anti-neoplastic prostaglandin 15-deoxy Δ12,14 PGJ2 (15d-PGJ2). BEZ increased PGD2 synthesis via the generation of reactive oxygen species (ROS) and activation of the lipid peroxidation pathway. MPA directed prostaglandin synthesis towards 15d-PGJ2 by inhibiting the PGD2 11β -ketoreductase activity of the aldo-keto reductase AKR1C3, which metabolises PGD2 to 9α11β-PGF2α. B/M treatment resulted in growth arrest, apoptosis and cell differentiation in both AML cell lines and primary AML cells and these actions were recapitulated by treatment with 15d-PGJ2. Importantly, the actions of B/M had little effect on the survival of normal adult myeloid progenitors. Significance: Collectively our data demonstrate that B/M treatment of AML cells elevated ROS and delivered the anti-neoplastic actions of 15d-PGJ2. These observations provide the mechanistic rationale for the redeployment of B/M in elderly and relapsed AML