Associations of height, leg length, and lung function with cardiovascular risk factors in the Midspan Family Study

<b>Background</b>: Taller people and those with better lung function are at reduced risk of coronary heart disease (CHD). Biological mechanisms for these associations are not well understood, but both measures may be markers for early life exposures. Some studies have shown that leg length, an indicator of pre-pubertal nutritional status, is the component of height most strongly associated with CHD risk. Other studies show that height-CHD associations are greatly attenuated when lung function is controlled for. This study examines (1) the association of height and the components of height (leg length and trunk length) with CHD risk factors and (2) the relative strength of the association of height and forced expiratory volume in one second (FEV1) with risk factors for CHD. <b>Subjects and methods</b>: Cross sectional analysis of data collected at detailed cardiovascular screening examinations of 1040 men and 1298 women aged 30–59 whose parents were screened in 1972–76. Subjects come from 1477 families and are members of the Midspan Family Study. <b>Setting</b>: The towns of Renfrew and Paisley in the West of Scotland. <b>Results</b>: Taller subjects and those with better lung function had more favourable cardiovascular risk factor profiles, associations were strongest in relation to FEV1. Higher FEV1 was associated with lower blood pressure, cholesterol, glucose, fibrinogen, white blood cell count, and body mass index. Similar, but generally weaker, associations were seen with height. These associations were not attenuated in models controlling for parental height. Longer leg length, but not trunk length, was associated with lower systolic and diastolic blood pressure. Longer leg length was also associated with more favourable levels of cholesterol and body mass index than trunk length. <b>Conclusions</b>:These findings provide indirect evidence that measures of lung development and pre-pubertal growth act as biomarkers for childhood exposures that may modify an individual's risk of developing CHD. Genetic influences do not seem to underlie height-CHD associations

The efficacy of problem-solving treatments after deliberate self-harm: meta-analysis of randomized controlled trials with respect to depression, hopelessness and improvement in problems

Background. Brief problem-solving therapy is regarded as a pragmatic treatment for deliberate self-harm (DSH) patients. A recent meta-analysis of randomized controlled trials (RCTs) evaluating this approach indicated a trend towards reduced repetition of DSH but the pooled odds ratio was not statistically significant. We have now examined other important outcomes using this procedure, namely depression, hopelessness and improvement in problems. Method. Six trials in which problem-solving therapy was compared with control treatment were identified from an extensive literature review of RCTs of treatments for DSH patients. Data concerning depression, hopelessness and improvement in problems were extracted. Where relevant statistical data (e.g. standard deviations) were missing these were imputed using various statistical methods. Results were pooled using meta-analytical procedures. Results. At follow-up, patients who were offered problem-solving therapy had significantly greater improvement in scores for depression (standardized mean difference =[minus sign]0·36; 95% CI [minus sign]0·61 to [minus sign]0·11) and hopelessness (weighted mean difference =[minus sign]3·2; 95% CI [minus sign]4·0 to [minus sign]2·41), and significantly more reported improvement in their problems (odds ratio = 2·31; 95% CI 1·29 to 4·13), than patients who were in the control treatment groups. Conclusions. Problem-solving therapy for DSH patients appears to produce better results than control treatment with regard to improvement in depression, hopelessness and problems. It is desirable that this finding is confirmed in a large trial, which will also allow adequate testing of the impact of this treatment on repetition of DSH

Collective Oscillations of Vortex Lattices in Rotating Bose-Einstein Condensates

The complete low-energy collective-excitation spectrum of vortex lattices is discussed for rotating Bose-Einstein condensates (BEC) by solving the Bogoliubov-de Gennes (BdG) equation, yielding, e.g., the Tkachenko mode recently observed at JILA. The totally symmetric subset of these modes includes the transverse shear, common longitudinal, and differential longitudinal modes. We also solve the time-dependent Gross-Pitaevskii (TDGP) equation to simulate the actual JILA experiment, obtaining the Tkachenko mode and identifying a pair of breathing modes. Combining both the BdG and TDGP approaches allows one to unambiguously identify every observed mode.Comment: 5 pages, 4 figure

Changes in psychological need satisfaction

Abstract: Objective: (a) Examine longitudinal measurement invariance of scores from psychological need satisfaction (PNS) scales and (b) examine if changes in PNS were associated with change in moderate-to-vigorous physical activity (MVPA). Methods: Adolescents (N=842, Mage = 10.8, SD = .6) enrolled in the Monitoring Activities of Teenagers to Comprehend their Habits (MATCH) study completed measures of PNS and MVPA every 4 months over a 3 year period (2011-14) for a total of nine times. Results: PNS scores demonstrated strong longitudinal measurement invariance (i.e., invariant factor loadings and intercepts). Latent growth curve modeling indicated that a factor representing perceptions of all three PNS variables was positively associated with MVPA at Time 1 (β = .566, p<.05), and that increases in the common PNS factor were associated with increases in MVPA (β = .545, p<.05) with a large effect size (R2initial MVPA=.316; R2change in MVPA=.301). In an alternative model, MVPA at Time 1 was associated with perceived common PNS at Time 1 (β=.602, p<.001), and increases in MVPA were associated with increases in common PNS (β=.667, p<.001) with a large effect size (R2initial PNS=.363 of the R2change in PNS=.426). Conclusions: Longitudinal measurement invariance was supported, and therefore PNS scores could be used to study change over time. Further, two equally well fitting models were found suggesting that change in PNS can be both an antecedent and an outcome of MVPA. As such, both PNS and MVPA could be targeted in interventions aimed at increasing need satisfaction or MVPA

Leisure-time physical activity in individuals with osteoporosis : associations with psychological well-being

With approximately 16% of the Canadian population living with osteoporosis, and rates expected to increase (Osteoporosis Canada, 2009), cost-effective treatment modalities that improve bone health and psychological well-being reflect an important public health agenda. Physical activity has been implicated as one non-pharmaceutical mechanism to help improve psychological well-being in the general population (Fox, Stathi, McKenna, & Davis, 2007) and in people diagnosed with osteoporosis (Osteoporosis Canada, 2007). The purpose of this investigation was to determine the association between leisure-time physical activity (LTP A) and well-being in people diagnosed with osteoporosis. A secondary purpose, using Basic Needs Theory (BNT; Deci & Ryan, 2002) was to determine if the fulfillment of three psychological needs (i.e., competence, autonomy and relatedness) mediated the relationship between LTP A and well-being. People diagnosed with osteoporosis (N= 190; Mage = 68.14; SDage = 11.54) were asked to complete a battery of questionnaires assessing L TP A, hedonic and eudaimonic well-being and perceived psychological need satisfaction in physical activity contexts. Bivariate correlations revealed a pattern of negligible (r's -0.02 to 0.35) to small correlations between LTP A and well-being with contextual positive affect (r = 0.24) and subjective vitality (r = 0.22) demonstrating statistical significance (p < .01). Results of the multiple mediation analysis indicated that perceived satisfaction of the three psychological needs mediated the relationship between LTPA and well-being with perceived competence emerging as a unique mediator. As such, LTP A was positively associated with well-being in people who are diagnosed with osteoporosis, and the fulfillment of the three psychological needs may be the mechanism through which this 111 effect is carried. Health promotion specialists and practitioners should encourage patients with osteoporosis to engage in LTP A, and support their needs for competence, autonomy and relatedness. Practical implications for researchers and health promotion specialists are discussed in terms ofthe results of this investigation

Don't be so hard on yourself! Changes in self-compassion during the first year of university are associated with changes in well-being

Introduction&nbsp; Well-being declines during the first year of university. We examined if change in self-compassion was indirectly related to change in well-being through change in psychological need satisfaction during the first year of university.&nbsp; Methods&nbsp; First year university students (N=189, 77.2% female) completed self-report questionnaires at the beginning of the first semester and approximately five months later. Path analysis and bootstrapping procedures were used to examine residualized change scores.&nbsp; Results&nbsp; Change in self-compassion was positively related to (ps&lt;0.05) change in psychological need satisfaction (&beta;=0.49) and negatively related to change in negative affect (&beta;=&minus;0.24). Change in psychological need satisfaction was positively associated (ps&lt;0.05) with change in vitality (&beta;=0.58) and change in positive affect (&beta;=0.52) and negatively associated with change in negative affect (&beta;=&minus;0.29). Change in self-compassion was indirectly related to change in vitality (b=0.56, 95% bootstrapped bias corrected confidence interval (BcCI)[0.38, 0.77]), positive affect (b=0.41, 95%BcCI [0.27, 0.58]), and negative affect (b=&minus;0.26, 95%BcCI[&minus;0.41, &minus;0.13]) through change in psychological need satisfaction.&nbsp; Conclusions&nbsp; During the first year of university, change in self-compassion was associated with change in well-being because self-compassion enhanced psychological need satisfaction. Results highlight the potential of enhancing self-compassion during first year university to help mitigate student declines in well-being

Child suicide rates during the COVID-19 pandemic in England

BACKGROUND: There is concern about the impact of COVID-19, and the control measures to prevent the spread, on children's mental health. The aim of this work was to identify if there had been a rise of childhood suicide during the COVID pandemic. METHOD: Using data from England's National Child Mortality Database (NCMD) the characteristics and rates of children dying of suicide between April to December 2020 were compared with those in 2019. In a subset (1(st) January to 17(th) May 2020) further characteristics and possible contributing factors were obtained. RESULTS: A total of 193 likely childhood deaths by suicide were reported. There was no evidence overall suicide deaths were higher in 2020 than 2019 (RR 1.09 (0.80-1.48), p=0.584) but weak evidence that the rate in the first lockdown period (April to May 2020) was higher than the corresponding period in 2019 (RR 1.56 (0.86-2.81), p=0.144). Characteristics of individuals were similar between periods. Social restrictions (e.g. to education), disruption to care and support services, tensions at home and isolation appeared to be contributing factors. LIMITATIONS: As child suicides are fortunately rare, the analysis is based on small numbers of deaths with limited statistical power to detect anything but major increases in incidence. CONCLUSION: We found no consistent evidence that child suicide deaths increased during the COVID-19 pandemic although there was a possibility that they may have increased during the first UK lockdown. A similar peak was not seen during the following months, or the second lockdown

Exploring the effects of cigarette smoking on inflammatory bowel disease using Mendelian randomisation

Background. Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). Methods. We used observational techniques followed by Mendelian randomisation (MR) to explore if smoking is a causal factor in the development of IBD and its subtypes.Results. In those who have ever smoked, we observed increased risk of IBD, and, in current smokers, we observed increased risk of Crohn’s disease and decreased risk of Ulcerative Colitis. However, our MR analyses found little evidence that smoking affects the development of IBD. Conclusion. Overall, our results suggest that smoking does not causally influence the risk of IBD