Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study

Background: Brain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear. Aims: To investigate the relationship between baseline and incident depression and progression of white matter changes. Method: In a longitudinal multicentre pan-European study (Leukoaraiosis and Disability in the elderly, LADIS), participants aged over 64 underwent baseline magnetic resonance imaging (MRI) and clinical assessments. Repeat scans were obtained at 3 years. Depressive outcomes were assessed in terms of depressive episodes and the Geriatric Depression Scale (GDS). Progression of WMC was measured using the modified Rotterdam Progression scale. Results: Progression of WMC was significantly associated with incident depression during year 3 of the study (P = 0.002) and remained significant after controlling for transition to disability, baseline WMC and baseline history of depression. There was no significant association between progression of WMC and GDS score, and no significant relationship between progression of WMC and history of depression at baseline. Conclusions: Our results support the vascular depression hypothesis and implicate WMC as causal in the pathogenesis of late-life depression.Full Tex

Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

Objective To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these changes

Global burden of small vessel disease-related brain changes on MRI predicts cognitive and functional decline

Background and Purpose- Cerebral small vessel disease is characterized by a wide range of focal and global brain changes. We used a magnetic resonance imaging segmentation tool to quantify multiple types of small vessel disease-related brain changes and examined their individual and combined predictive value on cognitive and functional abilities. Methods- Magnetic resonance imaging scans of 560 older individuals from LADIS (Leukoaraiosis and Disability Study) were analyzed using automated atlas- and convolutional neural network-based segmentation methods yielding volumetric measures of white matter hyperintensities, lacunes, enlarged perivascular spaces, chronic cortical infarcts, and global and regional brain atrophy. The subjects were followed up with annual neuropsychological examinations for 3 years and evaluation of instrumental activities of daily living for 7 years. Results- The strongest predictors of cognitive performance and functional outcome over time were the total volumes of white matter hyperintensities, gray matter, and hippocampi (PPeer reviewe

Shape Abnormalities of the Caudate Nucleus Correlate with Poorer Gait and Balance: Results from a Subset of the LADIS Study

Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in fronto-striatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter changes (WMC) on MRI has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction

Skolliv - om skolan som arbetsplats

Hur behåller man hälsan som lärare? Vad händer i mötet mellan politiska ambitioner och kommunal skolverklighet? Hur påverkar den ordlösa kommunikationen stämningen i klassrummet? Vad händer när mätbar kunskap blir viktigare än användbar kunskap? Kan man vara nöjd som lärare men missnöjd som anställd? Skolan har blivit en ideologisk ”het potatis” som väcker engagemang, både inom och utom skolans värld. Debatten är högljudd om till exempel betygen, ordningen i skolan och lärarnas arbetsmiljö. I ”Skolliv – om skolan som arbetsplats” presenteras aktuell skolforskning på ett sätt som gör den tillgänglig för alla som är intresserade av vad som händer i skolan

Nordic Conference on Future of Work : Towards the ILO Centenary

In connection to the 100th anniversary of the ILO in 2019, the Nordic Council of Ministers arranged a conference to debate the future of work in the Nordics. The event was held on the 4th-5th of April in Reykjavik and was the last in a series of four annual conferences. The debates centered on the changing labour market and whether the Nordic model will be able to adapt to this. The conference lasted two days, each with a particular theme: 1) Future of Work – where the future of the Nordic model was discussed 2) Gender Equality – where the debate revolved around the challenges and solutions regarding the inequalities between men and women on the labour market. The programme included perspectives from all the Nordic countries, as well as from international organisations such as the ILO and the OECD, international companies, Nordic labour market authorities, social partners and companies

Learning from contrasts: first-year students writing themselves into academic literacy

The contribution of this article is to highlight how exploring various writing genres in the beginning of higher education can contribute to academic literacy. While many studies have addressed the transition into academia by focusing on academic writing, the use of various writing genres has scarcely been researched. Based on the thematic analysis of focus-group interviews that explore first-year students’ experience of writing in academia, we present and discuss three emerging themes: 1) academic writing as a dull and constricted world, 2) playing with and playing out identities through writing in various genres, and 3) learning academic writing from contrasts. Our research indicates that starting with other writing genres than the academic genre might foster an experience of mastery that could enhance self-efficacy when it comes to academic writing. Moreover, discovering contrasts to academic writing can help students to understand the boundaries and characteristics of academic writing

Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS

White matter changes (WMC) are common magnetic resonance imaging (MRI) findings, particularly in the elderly. Recent studies such as the Leukoaraiosis and Disability Study (LADIS) have found that WMC relate to adverse outcomes including cognitive impairm

Nordic Future of Work Conference : The future labour market in the Nordic countries – the impact of technological development on jobs and the need for competence

In the runup to the ILO's 100th anniversary in 2019, the ILO asked the Nordic countries to contribute to the debate about how the future of work can be shaped. the Stockholm conference gathered more than 120 participants, and was number three out of four annual Nordic conferences. The debate was divided into four main themes: 1) How will the technological developments affect the Labour market? 2) How are the Nordic countries preparing for a more digitised and automated labour market? 3) How are companies and industries affected by the technological development? 4) How to deal with the need for skills? The programme included perspectives from all of the Nordic countries, from multinational organisations such as the OECD and the ILO, international companies such as McKinsey and Google, Nordic labour market authorities, social partners and companies undergoing changes