Evaluation of The Renal Function in The Intrauterine Growth Restricted Rats and The Effect of Maternal Glucocorticoids

The purpose of the study was to determine the effect of maternal glucocorticoids on experimental growth retarded rats and the effect of maternal undernutrition in different gestation periods for function of the kidney. This study had two sections. In the first section, 5 groups were formed. 10g/d diet was given in the 1st, 2nd, and 3rd trimester and throughout the pregnancy period. The control group was fed a normal diet. In the second section, 3 groups formed and all the rats take 10 g/d diet throughout pregnancy period. To determine the effect of endogenous glucocorticoids first group was treated with metyrapone, second group metyrapone+dexamethasone and the placebo injected saline until 14 days of pregnancy. The offsprings body and kidney weights were detected in the 0, 3rd and 20th weeks of age. Renal extraction functions and blood pressures from tail detected in the 20th week of age. Urinary excretion and glomerular filtration rate were low in rats that had dietary restriction in the last trimester. The glomerular filtration rates were found to be low in the group that had diet restriction during the whole pregnancy. Blood pressure values were found to be lower in the group that had diet restriction during their pregnancy compared to the control group. Kidney weights were similar in all groups in the first phase. It was observed that renal excretion functions were preserved in the group receiving metyrapone treatment, but there was no statistically significant difference between the results. Low blood pressures were normalized with metyrapone treatment. The kidney sizes at the 20th week of the rats which receiving metyrapone treatment were found to be smaller than those receiving physiological saline solution. Food restriction destroys renal functions but no effects with high blood pressure in adulthood. Glucocortiod exposure in pregnancy may reduce renal development

A validation of diagnostic score for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in Turkish children

PubMe

Proceedings of the 24th Paediatric Rheumatology European Society Congress: Part three

From Springer Nature via Jisc Publications Router.Publication status: PublishedHistory: collection 2017-09, epub 2017-09-0

A Male Infant with Congenital Chylous Ascites Accompanied by Hypertension

Background: Congenital chylous ascites is a condition that arises from a disorder of the abdominal lymphatic system

Occupational exposures to blood and body fluids among health care workers: A questionary survey

The major concern following occupational exposures of the health care workers is the possible transmission of blood-borne pathogens, especially hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV). This questionary survey was undertaken to determine the frequency and epidemiological characteristics of incidents involving biological exposures to blood and body fluids among health care workers (HCWs), at a University Hospital, in Izmir, Turkey. The survey was conducted using a questionnaire including questions related to demographics and epidemiological information. A total of 350 HCWs [162 physicians (academicians, seniors and juniors), 71 nurses, 55 interns of medical faculty, 45 cleaning staff, 12 nurse's aides, five technical/ managerial staff] were included to the survey. Of them, 203 (58%) have reported at least one exposure, 108 (%53.2) of them were physicians (p < 0.000) and 53 (26.1%) were nurses. The highest injury rate was reported by the nurse group (74.6%) followed by physicians (66.7%), cleaning staffs (57.8%) and interns (23.6%). Most of the occupational injuries (62.5%) have eventuated in the last one year. Types of exposure included percutaneous injury (97%) which was commonly caused by needle recapping (36%), suturing (25.6%) and handling of garbage bags (10.3%). Of the exposed HCWs, 138 (68%) have reported to use a protective equipment during the exposure and only 51.7%.sought for medical assistance from the related department. Among 350 HCWs, 291 (83.1 %) had been previously vaccinated against HBV, while two (0.6%) HCWs were chronically infected with HBV, unrelated with exposures. No transmission was reported following 16 incidents, in which the index patient was HBV, HCV or HIV carrier. In conclusion, percutanenous injuries are still common among HCWs. The results support the importance of the use of universal precautions and safety-enhanced devices, introducing effective training and efficient vaccination programs against HBV, in the clinical settings

Niveles de magnesio en niños con enfermedad renal crónica estadios 1-3

Objective: The objective of this study was to assess serum and urinary magnesium levels in children who have chronic kidney disease stages 1-3. Methods: Eighty-seven patients who were followed at pediatric nephrology department for chronic kidney disease were included in the study. Age, gender, magnesium, dietary magnesium, and creatinine levels, and fractionated magnesium excretion for all cases were recorded. Patients with chronic kidney disease and control groups were compared in terms of these data. Results: Thirty-nine cases with chronic kidney disease were stage 1, 26 were stage 2, and 22 were stage 3. Average age was 9.9 ± 2.8 years in the control group and 10.2 ± 2.6 years in the chronic kidney disease group. The serum magnesium levels were significantly higher in the stage 3 group than in the control group (P<0.001). Also, in stage 3, fractionated magnesium excretion levels were higher compared to the control group (P<0.001). Conclusion: In chronic kidney disease with advancing renal failure, hypermagnesemia is frequently seen. Serum magnesium levels should be measured periodically in all the children with chronic kidney disease stage 3 to investigate magnesium abnormalities and assess clinical results.Objetivo: El objetivo de este estudio fue evaluar los niveles de magnesio sérico y urinario en niños con enfermedad renal crónica en estadios 1-3. Material y métodos: Se incluyeron en el estudio 87 pacientes que tuvieron seguimiento en el servicio de nefrología pediátrica por enfermedad renal crónica. Se registraron los siguientes datos: edad, sexo, niveles de magnesio, ingesta de alimentos con magnesio, y creatinina, así como también la excreción fraccionada de magnesio para todos estos casos. Sobre la base de dichos datos, se compararon los pacientes con enfermedad renal crónica y los grupos de control. Resultados: De los 87 casos de enfermedad renal crónica, 39 se hallaban en estadio 1; 26, en estadio 2, y 22, en estadio 3. La edad promedio fue de 9,9 ± 2,8 años en el grupo control y de 10,2 ± 2,6 años en el grupo de enfermedad renal crónica. Los niveles de magnesio en suero fueron significativamente más altos en el grupo del estadio 3 que en el grupo control (p <0,001). Además, en el estadio 3, los niveles de excreción fraccionada de magnesio fueron más altos en comparación con el grupo control (p <0,001). Conclusión: En la enfermedad renal crónica con insuficiencia renal avanzada, se observa con frecuencia una hipermagnesemia. Los niveles séricos de magnesio deben medirse periódicamente en todos los niños con enfermedad renal crónica en estadio 3 para investigar las anomalías del magnesio y evaluar los resultados clínicos

Magnesium levels in children with chronic kidney disease stages 1- Niveles de magnesio en niños con enfermedad renal crónica estadios 1-3

© 2021, Asociacion Regional de Dialisi y Transplantes Renales de Capital Federal y Provincia de Buenos Aires. All rights reserved.Objective: The objective of this study was to assess serum and urinary magnesium levels in children who have chronic kidney disease stages 1-3. Methods: Eighty-seven patients who were followed at pediatric nephrology department for chronic kidney disease were included in the study. Age, gender, magnesium, dietary magnesium, and creatinine levels, and fractionated magnesium excretion for all cases were recorded. Patients with chronic kidney disease and control groups were compared in terms of these data. Results: Thirty-nine cases with chronic kidney disease were stage 1, 26 were stage 2, and 22 were stage 3. Average age was 9.9 ± 2.8 years in the control group and 10.2 ± 2.6 years in the chronic kidney disease group. The serum magnesium levels were significantly higher in the stage 3 group than in the control group (P<0.001). Also, in stage 3, fractionated magnesium excretion levels were higher compared to the control group (P<0.001). Conclusion: In chronic kidney disease with advancing renal failure, hypermagnesemia is frequently seen. Serum magnesium levels should be measured periodically in all the children with chronic kidney disease stage 3 to investigate magnesium abnormalities and assess clinical results

The remarkable characteristics of the children with colchicine-resistant familial Mediterranean fever in Turkey

Objective