Weakly nonlinear ion sound waves in gravitational systems

Ion sound waves are studied in a plasma subject to gravitational field. Such systems are interesting by exhibiting a wave growth that is a result of energy flux conservation in inhomogeneous systems. The increasing wave amplitude gives rise to an enhanced interaction between waves and plasma particles that can be modeled by a modified Korteweg-de Vries equation. Analytical results are compared with numerical Particle-in-Cell simulations of the problem. Our code assumes isothermally Boltzmann distributed electrons while the ion component is treated as a collection of individual particles interacting through collective electric fields. Deviations from quasi neutrality are allowed for.Comment: 30 pages, 9 figure

Zakharov simulations of beam-induced turbulence in the auroral ionosphere

Recent detections of strong incoherent scatter radar echoes from the auroral F region, which have been explained as the signature of naturally produced Langmuir turbulence, have motivated us to revisit the topic of beam-generated Langmuir turbulence via simulation. Results from one-dimensional Zakharov simulations are used to study the interaction of ionospheric electron beams with the background plasma at the F region peak. A broad range of beam parameters extending by more than 2 orders of magnitude in average energy and electron number density is considered. A range of wave interaction processes, from a single parametric decay, to a cascade of parametric decays, to formation of stationary density cavities in the condensate region, and to direct collapse at the initial stages of turbulence, is observed as we increase the input energy to the system. The effect of suprathermal electrons, produced by collisional interactions of auroral electrons with the neutral atmosphere, on the dynamics of Langmuir turbulence is also investigated. It is seen that the enhanced Landau damping introduced by the suprathermal electrons significantly weakens the turbulence and truncates the cascade of parametric decays

Socioeconomic and behavioral factors associated with tuberculosis diagnostic delay in Lima, Peru

Early detection and diagnosis of tuberculosis (TB) is a global priority. Prolonged symptom duration prior to TB diagnosis is associated with increased morbidity, mortality and risk of transmission. We aimed to determine socioeconomic and behavioral factors associated with diagnostic delays among patients with TB. Data were collected from 105 patients with TB using a semi-structured interview guide in Lima, Peru. Factors associated with diagnostic delay were analyzed using negative binomial regression. The median delay from when symptoms commenced and the first positive diagnostic sample in public health facilities was 57 days (interquartile range (IQR): 28-126). In multivariable analysis, greater diagnostic delay was independently associated with patient older age; female sex; lower personal income prior to diagnosis; living with fewer people; and having more visits to professional health facilities prior to diagnosis (all p<0.05). Patients who first sought care at a private health facility had more visits overall to professional health facilities prior to diagnosis than those who first sought care from public or insured employee health facilities and had longer diagnostic delay in analysis adjusted for age and sex. Patients with TB were significantly more likely to first self-medicate than to visit professional health facilities prior to diagnosis (p=0.003). Thus, diagnostic delay was prolonged, greatest among older, low-income women and varied according to the type of care sought by individuals when their symptoms commenced. These findings suggest that TB case finding initiatives should target vulnerable groups in informal and private health facilities, where many patients with TB first seek healthcare

Why wait? The social determinants underlying tuberculosis diagnostic delay.

BACKGROUND: Early detection and diagnosis of tuberculosis remain major global priorities for tuberculosis control. Few studies have used a qualitative approach to investigate the social determinants contributing to diagnostic delay and none have compared data collected from individual, community, and health-system levels. We aimed to characterize the social determinants that contribute to diagnostic delay among persons diagnosed with tuberculosis living in resource-constrained settings. METHODS/PRINCIPLE FINDINGS: Data were collected in public health facilities with high tuberculosis incidence in 19 districts of Lima, Peru. Semi-structured interviews with persons diagnosed with tuberculosis (n = 105) and their family members (n = 63) explored health-seeking behaviours, community perceptions of tuberculosis and socio-demographic circumstances. Focus groups (n = 6) were conducted with health personnel (n = 35) working in the National Tuberculosis Program. All interview data were transcribed and analysed using a grounded theory approach. The median delay between symptom onset and the public health facility visit that led to the first positive diagnostic sample was 57 days (interquartile range 28-126). The great majority of persons diagnosed with tuberculosis distrusted the public health system and sought care at public health facilities only after exhausting other options. It was universally agreed that persons diagnosed with tuberculosis faced discrimination by public and health personnel. Self-medication with medicines bought at local pharmacies was reported as the most common initial health-seeking behaviour due to the speed and low-cost of treatment in pharmacies. Most persons diagnosed with tuberculosis initially perceived their illness as a simple virus. CONCLUSIONS: Diagnostic delay was common and prolonged. When individuals reached a threshold of symptom severity, they addressed their health with the least time-consuming, most economically feasible, and well-known healthcare option available to them. In high-burden settings, more human and material resources are required to promote tuberculosis case-finding initiatives, reduce tuberculosis associated stigma and address the social determinants underlying diagnostic delay

Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World

The metabolic conversion of dietary omega-3 and omega-6 18 carbon (18C) to long chain (>20 carbon) polyunsaturated fatty acids (LC-PUFAs) is vital for human life. The rate-limiting steps of this process are catalyzed by fatty acid desaturase (FADS) 1 and 2. Therefore, understanding the evolutionary history of the FADS genes is essential to our understanding of hominin evolution. The FADS genes have two haplogroups, ancestral and derived, with the derived haplogroup being associated with more efficient LC-PUFA biosynthesis than the ancestral haplogroup. In addition, there is a complex global distribution of these haplogroups that is suggestive of Neanderthal introgression. We confirm that Native American ancestry is nearly fixed for the ancestral haplogroup, and replicate a positive selection signal in Native Americans. This positive selection potentially continued after the founding of the Americas, although simulations suggest that the timing is dependent on the allele frequency of the ancestral Beringian population. We also find that the Neanderthal FADS haplotype is more closely related to the derived haplogroup and the Denisovan clusters closer to the ancestral haplogroup. Furthermore, the derived haplogroup has a time to the most recent common ancestor of 688,474years before present. These results support an ancient polymorphism, as opposed to Neanderthal introgression, forming in the FADS region during the Pleistocene with possibly differential selection pressures on both haplogroups. The near fixation of the ancestral haplogroup in Native American ancestry calls for future studies to explore the potential health risk of associated low LC-PUFA levels in these populations.Center for Health Related Informatics and Biomaging at the University of Maryland School of Medicine; National Institutes of Health/National Heart, Lung, and Blood Institute [U01 HL72518, HL087698, HL112064]; National Institutes of Health [R01-AT008621]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Observation and characterization of laser-driven Phase Space Electron Holes

The direct observation and full characterization of a Phase Space Electron Hole (EH) generated by laser-matter interaction is presented. This structure has been detected via proton radiography during the interaction between an intense laser pulse (t=1ns temporally flat-top, I= 10^14W/cm^2) and a gold 26 micron thick hohlraum. This technique has allowed us the simultaneous detection of propagation velocity, potential and electron density spatial profile across the EH with fine spatial and temporal resolution providing an unprecedentedly detailed experimental characterization