Antarctic atmospheric boundary layer observations with the Small Unmanned Meteorological Observer (SUMO)

Between&nbsp;January&nbsp;2012 and June&nbsp;2017 a small unmanned aerial system (sUAS), known as the Small Unmanned Meteorological Observer (SUMO), was used to observe the state of the atmospheric boundary layer in the Antarctic. During six Antarctic field campaigns, 116 SUMO flights were completed. These flights took place during all seasons over both permanent ice and ice-free locations on the Antarctic continent and over sea ice in the western Ross Sea. Sampling was completed during spiral ascent and descent flight paths that observed the temperature, humidity, pressure and wind up to 1000&thinsp;m above ground level and sampled the entire depth of the atmospheric boundary layer, as well as portions of the free atmosphere above the boundary layer. A wide variety of boundary layer states were observed, including very shallow, strongly stable conditions during the Antarctic winter and deep, convective conditions over ice-free locations in the summer. The Antarctic atmospheric boundary layer data collected by the SUMO sUAS, described in this paper, can be retrieved from the United States Antarctic Program Data Center (https://www.usap-dc.org, last access: 8&nbsp;March&nbsp;2021). The data for all flights conducted on the continent are available at https://doi.org/10.15784/601054 (Cassano, 2017), and data from the Ross Sea flights are available at https://doi.org/10.15784/601191 (Cassano, 2019). </div

Effects of Airplane Cabin Interiors on Egress I: Assessment of Anthropometrics, Seat Pitch, and Seat Width on Egress

6973GH-19-C-00102Within the Federal Aviation Administration (FAA) Reauthorization Act of 2018, Pub. L. No. 115-254 \ua7 577, Congress required that \u201c\u2026the Administrator of the Federal Aviation Administration shall issue regulations that establish minimum dimensions for passenger seats on aircraft operated by air carriers in interstate air transportation or intrastate air transportation, including minimums for seat pitch, width, and length, and that are necessary for the safety of passengers.\u201d This research project was developed to provide information to rule-makers within the FAA to meet this requirement

Effects of Airplane Cabin Interiors on Egress I: Assessment of Anthropometrics, Seat Pitch, and Seat Width on Egress, DOT-FAA-AM_21/01 [supporting datasets: videos]

6973GH-19-C-00102Because of the very large file sized of these videos, patrons will need to download the video files directly, using the "Direct Download" links provided in the README.These 60 video recordings represent the visual recordings of the measurement of the two research objectives of the study \u201cEffects of Airplane Cabin Interiors on Egress I: Assessment of Anthropometrics, Seat Pitch, and Seat Width on Egress," DOT/FAA/AM-21/01. The first objective was to determine what percentage of the American population, based on anthropometric measurements, would not be able to sit in transport airplane passenger seats at the currently narrowest and even narrower seat pitch. Second, this study sought to determine the effect of seat pitch and seat width on individual egress time during an aircraft evacuation.The 12 videos with file names which contain with the phrase "ExpSeatingMockupDay..." record participants sitting in or attempting to sit in a seat mock-up that matched the narrowest seat pitch they would experience in the evacuation trials, and to attempt to sit in or to sit in a seat mock-up of a narrower seat pitch than what would be presented in the evacuation trials. (See pages 9 and 10 of the related report for more information.) Each video is about 2 hours long, and shows a single camera view from the perspective of the left wall of an aircraft. The video records participant actions as each participant attempts to sit in the center seat of the third of three rows, and then the center seat of the second of three rows. The recordings are color video, without a soundtrack. Participant faces are blurred to protect individual privacy.The 48 videos with file names that start with "R01.mp4" and increment to "R48.mp4" are the recordings of the evacuations from CAMI FlexSim. (See pages 11 through 13 of the related report for more information.) Each video is about 45 seconds long, with the frame divided into 4 quarters, showing three views of the evacuation, and a single title slide with the date of the evacuation trial, and the trial number, which matches the file number on the recording. The view in the upper left of the frame is a view overhead and behind the flight attendant supervising the evacuation. The view in the upper right of the frame shows the exterior of the simulator to record how participants exit. The view in the lower right of frame shows the view from the rear of the simulator, as participants evacuate away from the camera to the front of the simulator. The lower left of the frame is the title slide. In the center of the frame is a timer, counting up the total time of the evacuation. The recordings are color video, without a soundtrack. Participant faces are blurred to protect individual privacy.The videos can be viewed on any modern video player

Effects of Airplane Cabin Interiors on Egress I: Assessment of Anthropometrics, Seat Pitch, and Seat Width on Egress, DOT-FAA-AM_21/01 [supporting datasets]

6973GH-19-C-00102Within the Federal Aviation Administration (FAA) Reauthorization Act of 2018, Pub. L. No. 115-254 \ua7 577, Congress required that \u201c\u2026the Administrator of the Federal Aviation Administration shall issue regulations that establish minimum dimensions for passenger seats on aircraft operated by air carriers in interstate air transportation or intrastate air transportation, including minimums for seat pitch, width, and length, and that are necessary for the safety of passengers.\u201d A total of 775 participants were recruited to assist with meeting two research objectives: first, to determine what percentage of the American population, based on anthropometric measurements, would be unable to sit in transport airplane passenger seats at the currently narrowest width and even narrower seat pitch. The second objective was to determine the effect of seat pitch and seat width on individual egress time. The study included 718 participants assigned to 12 groups who participated in up to four evacuations from the FAA\u2019s Flexible Aircraft Cabin Simulator (FlexSim), with various seat pitch and width combinations. Based on this study's results, currently flying seat pitches using seats of similar size or smaller than those used in this project can accommodate and not impede egress for 99% of the American population. This project also concluded that, similar to previous evacuation research, as long as ergonomic minimums are maintained, the transport airplane's interior configuration, including seat pitch and width, has not been shown to influence evacuations. This research project was developed to provide information to rule-makers within the FAA to meet this requirement

Early Secreted Antigen ESAT-6 of Mycobacterium tuberculosis Promotes Protective T Helper 17 Cell Responses in a Toll-Like Receptor-2-dependent Manner

Despite its relatively poor efficacy, Bacillus Calmette-Guérin (BCG) has been used as a tuberculosis (TB) vaccine since its development in 1921. BCG induces robust T helper 1 (Th1) immune responses but, for many individuals, this is not sufficient for host resistance against Mycobacterium tuberculosis (M. tb) infection. Here we provide evidence that early secreted antigenic target protein 6 (ESAT-6), expressed by the virulent M. tb strain H37Rv but not by BCG, promotes vaccine-enhancing Th17 cell responses. These activities of ESAT-6 were dependent on TLR-2/MyD88 signalling and involved IL-6 and TGF-β production by dendritic cells. Thus, animals that were previously infected with H37Rv or recombinant BCG containing the RD1 region (BCG::RD1) exhibited improved protection upon re-challenge with virulent H37Rv compared with mice previously infected with BCG or RD1-deficient H37Rv (H37RvΔRD1). However, TLR-2 knockout (TLR-2-/-) animals neither showed Th17 responses nor exhibited improved protection in response to immunization with H37Rv. Furthermore, H37Rv and BCG::RD1 infection had little effect on the expression of the anti-inflammatory microRNA-146a (miR146a) in dendritic cells (DCs), whereas BCG and H37RvΔRD1 profoundly induced its expression in DCs. Consistent with these findings, ESAT-6 had no effect on miR146a expression in uninfected DCs, but dramatically inhibited its upregulation in BCG-infected or LPS-treated DCs. Collectively, our findings indicate that, in addition to Th1 immunity induced by BCG, RD1/ESAT-6-induced Th17 immune responses are essential for optimal vaccine efficacy

Leveraging the NEON Airborne Observation Platform for socio‐environmental systems research

Abstract During the 21st century, human–environment interactions will increasingly expose both systems to risks, but also yield opportunities for improvement as we gain insight into these complex, coupled systems. Human–environment interactions operate over multiple spatial and temporal scales, requiring large data volumes of multi‐resolution information for analysis. Climate change, land‐use change, urbanization, and wildfires, for example, can affect regions differently depending on ecological and socioeconomic structures. The relative scarcity of data on both humans and natural systems at the relevant extent can be prohibitive when pursuing inquiries into these complex relationships. We explore the value of multitemporal, high‐density, and high‐resolution LiDAR, imaging spectroscopy, and digital camera data from the National Ecological Observatory Network’s Airborne Observation Platform (NEON AOP) for Socio‐Environmental Systems (SES) research. In addition to providing an overview of NEON AOP datasets and outlining specific applications for addressing SES questions, we highlight current challenges and provide recommendations for the SES research community to improve and expand its use of this platform for SES research. The coordinated, nationwide AOP remote sensing data, collected annually over the next 30 yr, offer exciting opportunities for cross‐site analyses and comparison, upscaling metrics derived from LiDAR and hyperspectral datasets across larger spatial extents, and addressing questions across diverse scales. Integrating AOP data with other SES datasets will allow researchers to investigate complex systems and provide urgently needed policy recommendations for socio‐environmental challenges. We urge the SES research community to further explore questions and theories in social and economic disciplines that might leverage NEON AOP data