Next-to-next-to-leading-order epsilon expansion for a Fermi gas at infinite scattering length

We extend previous work on applying the epsilon-expansion to universal properties of a cold, dilute Fermi gas in the unitary regime of infinite scattering length. We compute the ratio xi = mu/epsilon_F of chemical potential to ideal gas Fermi energy to next-to-next-to-leading order (NNLO) in epsilon=4-d, where d is the number of spatial dimensions. We also explore the nature of corrections from the order after NNLO.Comment: 28 pages, 14 figure

Estimating return levels from maxima of non-stationary random sequences using the Generalized PWM method

Since the pioneering work of Landwehr et al. (1979), Hosking et al. (1985) and their collaborators, the Probability Weighted Moments (PWM) method has been very popular, simple and efficient to estimate the parameters of the Generalized Extreme Value (GEV) distribution when modeling the distribution of maxima (e.g., annual maxima of precipitations) in the Identically and Independently Distributed (IID) context. When the IID assumption is not satisfied, a flexible alternative, the Maximum Likelihood Estimation (MLE) approach offers an elegant way to handle non-stationarities by letting the GEV parameters to be time dependent. Despite its qualities, the MLE applied to the GEV distribution does not always provide accurate return level estimates, especially for small sample sizes or heavy tails. These drawbacks are particularly true in some non-stationary situations. To reduce these negative effects, we propose to extend the PWM method to a more general framework that enables us to model temporal covariates and provide accurate GEV-based return levels. Theoretical properties of our estimators are discussed. Small and moderate sample sizes simulations in a non-stationary context are analyzed and two brief applications to annual maxima of CO<sub>2</sub> and seasonal maxima of cumulated daily precipitations are presented

Magnetocaloric effect and improved relative cooling power in (La0.7Sr0.3MnO3/SrRuO3) superlattices

Magnetic properties of a series of (La0.7Sr0.3MnO3/SrRuO3) superlattices, where the SrRuO3 layer thickness is varying, are examined. A room-temperature magnetocaloric effect is obtained owing to the finite size effect which reduces the TC of La0.7Sr0.3MnO3 layers. While the working temperature ranges are enlarged,, -DeltaSmax values remains similar to the values in polycrystalline La0.7Sr0.3MnO3. Consequently, the relative cooling powers are significantly improved, the microscopic mechanism of which is related to the effect of the interfaces at La0.7Sr0.3MnO3/SrRuO3 and higher nanostructural disorder. This study indicates that artificial oxide superlattices/multilayers might provide an alternative pathway in searching for efficient room-temperature magnetic refrigerators for (nano)microscale systems.Comment: 14^pages, 3 figures, Submitted to J. Phys. Cond. Ma

Enriched model categories and presheaf categories

We collect in one place a variety of known and folklore results in enriched model category theory and add a few new twists. The central theme is a general procedure for constructing a Quillen adjunction, often a Quillen equivalence, between a given V-model category and a category of enriched presheaves in V, where V is any good enriching category. For example, we rederive the result of Schwede and Shipley that reasonable stable model categories are Quillen equivalent to presheaf categories of spectra (alias categories of module spectra) under more general hypotheses. The technical improvements and modifications of general model categorical results given here are applied to equivariant contexts in a pair of sequels, where we indicate various directions of application.Comment: 45 pages. v4. A number of relatively small changes and updates from the previous version, intended to address the most recent referee's report. The most significant change is the addition of section 4.5, which discusses Muro's work on arranging for a cofibrant uni

Models of G-spectra as presheaves of spectra

Let G be a finite group. We give Quillen equivalent models for the category of G-spectra as categories of spectrally enriched functors from explicitly described domain categories to nonequivariant spectra. Our preferred model is based on equivariant infinite loop space theory applied to elementary categorical data. It recasts equivariant stable homotopy theory in terms of point-set level categories of G-spans and nonequivariant spectra. We also give a more topologically grounded model based on equivariant Atiyah duality.Comment: 38 pages. v4. A number of relatively small changes and corrections. The introduction has been rewritten in response to suggestions from a referee. To make this paper more self-contained, section 4 on enriched model categories of G-spectra has been added. A new section 5 addresses a minor error in the previous version

Correlation between glove use practices and compliance with hand hygiene in a multicenter study with elderly patients

In a study conducted in 11 health care settings for elderly patients, we demonstrated a significant negative correlation between the proportion of glove use outside any risk of exposure to body fluids and compliance with hand hygiene (P < .02). This result underscores a major limitation of strategies for controlling the spread of multidrug-resistant bacteria that recommend systematic glove use for each contact with carriers or their environment

Heptadentate chelates for 89Zr-radiolabelling of monoclonal antibodies

Herein, we report the synthesis of three new bifunctional heptadentate metal ion binding chelates derived from desferrioxamine B (DFO) linked to a tripeptide unit that comprises of a glutamic acid and two glycine residues. The three DFO derivatives were also functionalised with a photoactivatable aryl azide unit for light-triggered labelling of proteins. The chelates were obtained in 3 synthetic steps in good overall yields by using solid phase peptide synthesis (SPPS). Density Functional Theory (DFT) calculations were used to estimate thermodynamic formation constants (log β) of the corresponding Zr4+ complexes. Quantitative zirconium-89 radiolabelling (>95%) was obtained in <5 min at room temperature, and the stability of the radioconjugates toward different competitors (human serum, EDTA and Fe3+) was assessed in vitro. One-pot 89Zr-photoradiosynthesis produced [89Zr]Zr-2-onartuzumab directly from the formulated, clinical-grade sample MetMAb™, without pre-purifying the monoclonal antibody (mAb) component, with an isolated decay-corrected radiochemical yield of 36.4 ± 2.4%. PET imaging and biodistribution studies were performed in female athymic nude mice bearing subcutaneous xenografts derived from the MKN-45 human gastric cancer cell line to assess the pharmacokinetic profile and tumour binding of [89Zr]Zr-2-onartuzumab. Specific tumour uptake of [89Zr]Zr-2-onartuzumab was confirmed by using competitive inhibition (blocking) studies and bone uptake was significantly reduced compared to the parent DFO analogue

Critical Exponents of the pure and random-field Ising models

We show that current estimates of the critical exponents of the three-dimensional random-field Ising model are in agreement with the exponents of the pure Ising system in dimension 3 - theta where theta is the exponent that governs the hyperscaling violation in the random case.Comment: 9 pages, 4 encapsulated Postscript figures, REVTeX 3.

Actualités sur les co-infections VIH–VHC

Objectives To evaluate the incidence of HIV–HCV co-infections and analyse the outcome in co-infected patients. Epidemiology. Effects of antivirals The prevalence of the co-infection by the HCV thus varies from 10 to 14% on subjects who have sexual behaviors at risk at 80 or 90% on users of drug IV. Numerous studies showed that the infection by the HIV made worse the natural history of the infection by the HCV [J Acquir Immune Defic Syndr 6 1993 602–610; J Hepatol 28 1998 945–950]. On the other hand, the studies which endeavoured to appreciate the effect of the antiretroviral therapeutics on the natural history of the chronic hepatitis C, on the co-infected patients, are more discussed. In cohorts of big size, it was demonstrated that the hepatic mortality increased with the exposure to antiretrovirals. However, the duration of the antiretroviral treatment also reports the more important survival of the patients, which distorts credibly the figures. The effect of the infection by the HCV on the progress of the disease with HIV is more discussed. The patients infected by the HIV, in any case, have to benefit from the research for a co-infection by the viruses of hepatitis B and C (HBV and HCV). This screening must be renewed every year, in particular on the drug addicts patients or presenting behaviors at risk. Viral replication The research of a viral replication, must be implemented for any confirmed positive HCV serology. The research of the HCV RNA needs ultrasensitive techniques of molecular biology which allow a qualitative detection andor a quantification of the viral genome (viral load). The techniques of last generation of real-time PCR combine both approaches (detection and quantification). The viral load HCV is not correlated to the degree of hepatic disease and does not predict the severity of the hepatic disease, contrary to the correlation demonstrated in the infection by the HIV. On the other hand, it can be a predictive factor in the response to the treatment. The pretherapeutic check-up also includes a determination of the viral genotype because a strong involvement in the response to the treatment was clearly demonstrated. Hepatic fibrosis The hepatic fibrosis must be estimated on patients having a chronic hepatitis because it conditions the prognosis and the treatment of the hepatitis. The anatomopathological study after hepatic biopsy (DHB) remains the reference method. Recently, the development of non invasive methods of measure of the hepatic fibrosis improved the care of hepatitis C, notably the blood tests (fibrotest BioPredictive Paris, fibrometer BLS Angers) and physical measures as the impulsional elastometry (Fibroscan® Echosens) which substitutes more and more in practice to the draining hepatic biopsy. Treatment Numerous studies now validated the treatment associating interferon pegilated and ribavirine as the reference treatment on the co-infected patients HIV/HCV. This treatment involves a high virological response going from 14 to 36% in the patients infected by a genotype 1 and 2 and from 43 to 73% in the patients infected by a genotype 2 or 3. The duration of the treatment is 48 weeks. As well as usual virological factors on the mono-infected patients (genotype, viral load), the rate of CD4 is one of the best predictive factors with a good response. Many hopes go towards the new molecules in development (inhibitors of protease), inhibitors of polymerase), with promising results on the mono-infected patients. However, the toxicity of these molecules is not very well known at the moment in the co-infected patients. It is thus necessary to perform trials in this group of patient, by watching very carefully the toxicity of the therapeutic associations