Design and implementation of a bidirectional, secure and real time communication between Windows Phone 8 App and Windows Store App.

Emerging multimedia applications require real-time information delivery over computer networks. Traditionally, real-time communications have been using specific transport protocols resting multi-platform support and hindering service maintenance. But the latest transport protocols for real-time web applications enable to create low-latency services without requiring native applications and easily going through firewalls and proxies. On the last years, several frameworks offering real-time web communication have appeared. These frameworks implements different transport protocols as fall-back measure to ensure that the connection will be established independently of the technology available on client-side. As a first part of this project, some of these frameworks have been reviewed and compared given the devices targeted in this project: Windows Phone 8 and Windows 8. The second part of this project consist in developing a real-time service using a given real-time framework and applying the most recent tendencies on Software architecture and code recycling. Finally the solution has been tested and evaluated in two environments: on local networks and on Internet using on cloud services

Avaluació energètica de dos escoles per la fundació Ascamm, en col·laboració amb el projecte europeu ZEMedS

III Premi del CAATEEB al millor Projecte Fi de Carrera del curs 2013/14.El present treball de fi de grau s’ha realitzat gràcies a un conveni de la UPC amb la fundació privada Ascamm i forma part d’un projecte europeu de la IEE (Inteligent Energy Europe) anomenat ZEMedS (Zero Emissions Mediterranean Schools). El projecte ZEMedS vol estudiar diferents escoles de diferents països europeus amb clima mediterrani per rehabilitar-les energèticament i que arribin a assolir uns consums i unes emissions de nZEB (nearly Zero Emission Buildings). Es realitza un conjunt de fitxes per emmagatzemar tota la informació necessària per l’estudi del comportament energètic d’edificis i un anàlisi d’aquesta informació. Amb totes aquestes dades, s’utilitza el programa de simulació energètica “Design Builder” amb motor de càlcul Energy plus, per simular l’estat actual de les escoles i l’efecte de diferents propostes de millora. Els resultats demostren que és possible la realització d’una rehabilitació energètica en les escoles estudiades per tal que tinguin un consum energètic baix i unes emissions de CO2 dignes d’un edifici nZEB.Award-winnin

Nuevos datos sobre el paisaje vegetal de las primeras ocupaciones de Mallorca: el Coval Simó (Escorca, Mallorca)

The Coval Simó shelter provides some of the oldest evidence for settlement on the island of Mallorca and the Balearic archipelago. It also has the peculiarity of being a habitat in a mountain area, so that the human groups that settled there had to adapt their agricultural and farming sys­tem to this environment. The plant remains (wood charcoal and seeds) recovered in the occupation levels allow us to address these issues, since they are the result of the different activities developed in this cavity: fuel for domestic activities, food for livestock, etc. The results of this study show that between the III and II millennium cal BC, an agricultural system based on livestock and cereal farming was implement­ed, which exploited local forest formations to obtain resources, among them, firewood. The plants that were exploit­ed show the existence of juniper forests, with the presence of maples and legumes, among other shrubs and bushes.El Coval Simó constituye una de las evidencias más antiguas de poblamiento en la isla de Mallorca y en el ar­chipiélago balear. Tiene, además, la particularidad de ser un hábitat en zona de montaña, de modo que los grupos huma­nos que se asentaron allí debieron de adaptar su sistema agropecuario y de explotación del entorno a este medio. Los restos vegetales (carbones y semillas) recuperados en los niveles de ocupación del yacimiento permiten aproximarse a estas cuestiones, ya que son resultado de las distintas ac­tividades desarrolladas en esta cavidad: combustible para las actividades domésticas, alimento para el ganado, etc. Los resultados de este estudio muestran que entre el III y II milenio cal BC se implantó un sistema agropecuario basado en la ganadería y en el cultivo de cereales, que realizaba una explotación de las formaciones forestales locales para la ob­tención de recursos, entre ellos, el combustible leñoso. Las formaciones vegetales explotadas remiten a la existencia de bosques de enebros o sabinas, con presencia de arces y ma­torrales de leguminosas, entre otros arbustos y matas

Bones Pràctiques en el Disseny de Pàgines Web per a Dispositius Mòbils

[cat] Els dispositius mòbils amb capacitat per accedir a la xarxa d'informació global “Internet” són de cada cop més freqüents (Fig. 1) gràcies a l'abaratiment d'aquets dispositius. Si a aquesta tendència i afegim el sorgiment de múltiples ofertes d'accés a Internet que proporcionen les principals operadores de telefonia mòbil, obtenim que el nombre d'usuaris que utilitzen els dispositius mòbils per accedir a Internet s'incrementa dia a dia. Davant aquesta realitat, es fa necessari que les pàgines web contemplin aquestes noves plataformes d'accés, per a fer un “site” accessible i de fàcil navegació amb els recursos limitats que disposen els dispositius mòbils. En aquest article pretenem donar unes primeres directrius per a un bony disseny d'un plana web per mòbils

Early Detection of Corrosion-Induced Concrete Micro-cracking by Using Nonlinear Ultrasonic Techniques: Possible Influence of Mass Transport Processes

This work presents results allowing an unequivocal correlation of the observations of strong nonlinear elastic features of ultrasonic waves (values of the nonlinearity parameters exceeding the thresholds corresponding to undamaged states), with the critical events of the corrosion-induced surface cracking of reinforced cement-mortar specimens. These observations point to the possibility of the early detection of cracking using nonlinear ultrasonic (NLU) techniques. Experimental evidence is presented on the existence of active net mass transport processes, due to wick action, in the course of the corrosion tests, in the experimental conditions of this work. These phenomena might explain the observed abrupt shifting of the nonlinear parameter values (typically increasing and then decreasing post-peak, even reaching values typical of the undamaged state), and, partially, the high variability obtained for the values of the nonlinear parameters in damaged (cracked) states. Finally, some consequences are derived from the point of view of use of the NLU techniques in engineering practice, i.e., in surveys aimed at evaluating reinforced concrete structures affected by corrosion.This research was funded by the Spanish Agencia Estatal de Investigación (grant code BIA2016-80982-R) and by the European Regional Development Fund (grant code BIA2016-80982-R). M.M. acknowledges a pre-doctoral fellowship from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/04078)

Use of Non-Linear Ultrasonic Techniques to Detect Cracks Due to Steel Corrosion in Reinforced Concrete Structures

In this work, non-linear ultrasonic wave techniques have been used to detect the onset of micro-cracking due to steel corrosion in model reinforced concrete elements. The specimens were of prismatic shape with a single steel rebar. The corrosion was forced by admixing an appropriate amount of sodium chloride at the moment of preparing the concrete mix, and by the application of an electric field, using a constant current density power source, and making the steel rebar work as the anode, and an external counter-electrode as the cathode. The preliminary results indicate that the onset of cracking seems to be accompanied by the appearance of higher-harmonic generation at the output signal (harmonic distortion), when the system is excited by the means of an ultrasound wave with a burst central frequency. Other phenomena related to the micro-cracks induced by corrosion, such is the parametric generation with respect to the fundamental amplitude, have not been observed until now.This research was funded by the Spanish Agencia Estatal de Investigación (grant code BIA2016-80982-R) and by the European Regional Development Fund (grant code BIA2016-80982-R). M. M. acknowledges a pre-doctoral fellowship from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/04078)

EGFR Inhibition in Glioma Cells Modulates Rho Signaling to Inhibit Cell Motility and Invasion and Cooperates with Temozolomide to Reduce Cell Growth

Enforced EGFR activation upon gene amplification and/or mutation is a common hallmark of malignant glioma. Small molecule EGFR tyrosine kinase inhibitors, such as erlotinib (Tarceva), have shown some activity in a subset of glioma patients in recent trials, although the reported data on the cellular basis of glioma cell responsiveness to these compounds have been contradictory. Here we have used a panel of human glioma cell lines, including cells with amplified or mutant EGFR, to further characterize the cellular effects of EGFR inhibition with erlotinib. Dose-response and cellular growth assays indicate that erlotinib reduces cell proliferation in all tested cell lines without inducing cytotoxic effects. Flow cytometric analyses confirm that EGFR inhibition does not induce apoptosis in glioma cells, leading to cell cycle arrest in G1. Interestingly, erlotinib also prevents spontaneous multicellular tumour spheroid growth in U87MG cells and cooperates with sub-optimal doses of temozolomide (TMZ) to reduce multicellular tumour spheroid growth. This cooperation appears to be schedule-dependent, since pre-treatment with erlotinib protects against TMZ-induced cytotoxicity whereas concomitant treatment results in a cooperative effect. Cell cycle arrest in erlotinib-treated cells is associated with an inhibition of ERK and Akt signaling, resulting in cyclin D1 downregulation, an increase in p27kip1 levels and pRB hypophosphorylation. Interestingly, EGFR inhibition also perturbs Rho GTPase signaling and cellular morphology, leading to Rho/ROCK-dependent formation of actin stress fibres and the inhibition of glioma cell motility and invasion

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group