When a collective outcome triggers a rare individual event: a mode of metastatic process in a cell population

A model of early metastatic process is based on the role of the protein PAI-1, which at high enough extracellular concentration promotes the transition of cancer cells to a state prone to migration. This transition is described at the single cell level as a bi-stable switch associated with a subcritical bifurcation. In a multilevel reaction-diffusion scenario, the microenvironment of the tumor is modified by the proliferating cell population so as to push the concentration of PAI-1 above the bifurcation threshold. The formulation in terms of partial differential equations fails to capture spatio-temporal heterogeneity. Cellular-automata and agent-based simulations of cell populations support the hypothesis that a randomly localized accumulation of PAI-1 can arise and trigger the escape of a few isolated cells. Far away from the primary tumor, these cells experience a reverse transition back to a proliferative state and could generate a secondary tumor. The proposed role of PAI-1 in controlling this metastatic cycle is candidate to explain its role in the progression of cancer

Canonical Models of Geophysical and Astrophysical Flows: Turbulent Convection Experiments in Liquid Metals

Planets and stars are often capable of generating their own magnetic fields. This occurs through dynamo processes occurring via turbulent convective stirring of their respective molten metal-rich cores and plasma-based convection zones. Present-day numerical models of planetary and stellar dynamo action are not carried out using fluids properties that mimic the essential properties of liquid metals and plasmas (e.g., using fluids with thermal Prandtl numbers Pr < 1 and magnetic Prandtl numbers Pm ≪ 1). Metal dynamo simulations should become possible, though, within the next decade. In order then to understand the turbulent convection phenomena occurring in geophysical or astrophysical fluids and next-generation numerical models thereof, we present here canonical, end-member examples of thermally-driven convection in liquid gallium, first with no magnetic field or rotation present, then with the inclusion of a background magnetic field and then in a rotating system (without an imposed magnetic field). In doing so, we demonstrate the essential behaviors of convecting liquid metals that are necessary for building, as well as benchmarking, accurate, robust models of magnetohydrodynamic processes in Pm ≪  Pr < 1 geophysical and astrophysical systems. Our study results also show strong agreement between laboratory and numerical experiments, demonstrating that high resolution numerical simulations can be made capable of modeling the liquid metal convective turbulence needed in accurate next-generation dynamo models

An Ultra-High Speed Emulator Dedicated to Power System Dynamics Computation Based on a Mixed-Signal Hardware Platform

This paper presents an ultra-high speed hardware platform dedicated to power system dynamic (small signal) and transient (large signal) stability. It is based on an intrinsic parallel architecture which contains hybrid mixed-signal (analog and digital) circuits. For a given model, this architecture overcomes the speed of the numerical simulators by means of the so-called emulation approach. Indeed, the emulation speed does not depend on the power system size. This approach is nevertheless not competing against high-performance numerical simulators in term of accuracy and model complexity. It targets to complement the numerical simulators with the advantage of speed, portability, low cost and autonomous functioning. The proof of concept is a flexible and modular 96-node hardware platform. It is based on a reconfigurable array of power system buses called Field Programmable Power Network System (FPPNS). Details on this hardware are given. Two benchmark topologies with, respectively, 17 nodes and 57 nodes are provided. Comparisons with a digital simulator are done in terms of speed and accuracy. The calibration of the system is explained and different applications are proposed and discussed. The promising results of this hardware platform show that the design of a fully integrated solution containing hundreds of power system buses can be achieved in order to provide a low cost solution

Power network transient stability electronics emulator using mixed-signal calibration

The emerging field of power system emulation for real time smart grid management is very demanding in terms of speed and accuracy. This paper provides detailed information about the electronics calibration process of a high-speed power network emulator dedicated to the transient stability analysis of power systems. This emulator uses mixed-signal hardware to model the dynamic behavior of a power network. Special design allows the self-calibration of the analog electronics through successive measurements and correction steps. The calibration operation guarantees high resolution of the transient stability analysis results, so that they can be reliably used for operational planning and control on real power networks

A 3D architecture platform dedicated to high-speed computation for power system

This paper presents an innovative 3D hardware architecture for power system dynamic and transient stability. Based on an intrinsic parallel architecture by means of mixedsignal circuits (analog and digital) it overcomes the speed of numerical simulators for given models. This approach does not competing the accuracy and model complexity of the high performance numerical simulators. It intends to complement them with the advantage of speed, low-cost, portability and autonomous functions. The presented architecture provides an ultra-high speed platform by means of emulation principle. The proof of concept is an array of 4x24 nodes reconfigurable platform. Hardware details and comparisons with a reference digital simulator are given

Overview of retrospective data harmonisation in the MINDMAP project : process and results

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