Multi-component power spectra estimation method for multi-detector observations of the Cosmic Microwave Background

We present a new method for multi-component power spectra estimation in multi-frequency observations of the CMB. Our method is based on matching a model to the cross and auto power spectra of observed maps. All the component power spectra are estimated, as well as their mixing matrix. Noise power spectra are also estimated. The method has been applied to full-sky Planck simulations containing five astrophysical components and white noise. The beam smoothing effect is taken into account.Comment: 7 pages, 1 figure, proc. of the CMBnet workshop, 20-21 Feb. 2003 Oxford, UK. New Astronomy Reviews (eds. A. Melchiorri, J.I. Silk) in pres

Segmenting NBA's Chinese viewers based on their searched experiences

What do Chinese viewers look for when watching NBA games

Contribution of point sources to the soft gamma-ray Galactic emission

The nature of the soft gamma-ray (20-200 keV) Galactic emission has been a matter of debate for a long time. Previous experiments have tried to separate the point source contribution from the real interstellar emission, but with a rather poor spatial resolution, they concluded that the interstellar emission could be a large fraction of the total Galactic emission. INTEGRAL, having both high resolution and high sensitivity, is well suited to reassess more precisely this problem. Using the INTEGRAL core program Galactic Center Deep Exposure (GCDE), we estimate the contribution of detected point sources to the total Galactic flux.Comment: Proceedings of the 5th INTEGRAL Workshop, Munich 16-20 February 2004. ESA SP-55

Vidéo : Études médiévales et programmes scolaires : enjeux

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L’Université face au déferlement numérique

L’université française et la science qu’elle produit connaissent des mutations rapides. Elles sont lancées dans une course effrénée à l’innovation, sans cesse stimulée par les injonctions de l’État et des milieux économiques, ainsi que par la mode des classements internationaux, tel celui de Shanghai (Charle, Soulié, 2008). Depuis les années 1980, les innovations et les trajectoires technoscientifiques sont de plus en plus modelées par un nouveau régime de production néolibéral des sciences a..

European H2020 Project WORTECS Wireless Mixed Reality Prototyping

This paper presents European collaborative project WORTECS objectives and reports on the development of several radio and optical wireless prototypes and a demonstrator targeting mixed reality (MR) application. The aim is to achieve a net throughput of up to Tbps in an indoor heterogeneous network for the MR use case, which seems to be a high throughput "killer application" beyond 5G. A special routing device is associated with the demonstrator to select the most suitable wireless access technology. Post introduction to the project, an overview of the demonstrator is presented with details of the current progress of the prototypes

Localization of HIV-1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophages

<p>Abstract</p> <p>Background</p> <p>HIV-1 Vpr is a dynamic protein that primarily localizes in the nucleus, but a significant fraction is concentrated at the nuclear envelope (NE), supporting an interaction between Vpr and components of the nuclear pore complex, including the nucleoporin hCG1. In the present study, we have explored the contribution of Vpr accumulation at the NE to the Vpr functions, including G2-arrest and pro-apoptotic activities, and virus replication in primary macrophages.</p> <p>Results</p> <p>In order to define the functional role of Vpr localization at the NE, we have characterized a set of single-point Vpr mutants, and selected two new mutants with substitutions within the first α-helix of the protein, Vpr-L23F and Vpr-K27M, that failed to associate with hCG1, but were still able to interact with other known relevant host partners of Vpr. In mammalian cells, these mutants failed to localize at the NE resulting in a diffuse nucleocytoplasmic distribution both in HeLa cells and in primary human monocyte-derived macrophages. Other mutants with substitutions in the first α-helix (Vpr-A30L and Vpr-F34I) were similarly distributed between the nucleus and cytoplasm, demonstrating that this helix contains the determinants required for localization of Vpr at the NE. All these mutations also impaired the Vpr-mediated G2-arrest of the cell cycle and the subsequent cell death induction, indicating a functional link between these activities and the Vpr accumulation at the NE. However, this localization is not sufficient, since mutations within the C-terminal basic region of Vpr (Vpr-R80A and Vpr-R90K), disrupted the G2-arrest and apoptotic activities without altering NE localization. Finally, the replication of the Vpr-L23F and Vpr-K27M hCG1-binding deficient mutant viruses was also affected in primary macrophages from some but not all donors.</p> <p>Conclusion</p> <p>These results indicate that the targeting of Vpr to the nuclear pore complex may constitute an early step toward Vpr-induced G2-arrest and subsequent apoptosis; they also suggest that Vpr targeting to the nuclear pore complex is not absolutely required, but can improve HIV-1 replication in macrophages.</p

Low parathyroid hormone status induced by high dialysate calcium is an independent risk factor for cardiovascular death in hemodialysis patients

Here we studied a possible association between low parathyroid hormone (PTH) status and mortality in incident patients undergoing hemodialysis . A total of 1983 patients were included at baseline and prospectively followed for 24 months. Patients were classified according to their Kidney Disease: Improving Global Outcomes PTH status at baseline and at 12 months, and mortality evaluated at 12 to 24 months using adjusted Cox analysis. Factors potentially involved in PTH status variability between baseline and 12 months were analyzed. A decrease in serum PTH from normal or high to low values between baseline and 12 months was associated with significantly increased cardiovascular mortality at 12 to 24 months (hazard ratio, 2.03; 95% confidence interval, 1.22–3.36). For patients with high or normal baseline PTH levels, the main independent factor at 6 months for a decrease to low PTH levels at 12 months was high dialysate calcium (1.75 mmol/L), whereas prescription of non–calcium-based phosphate binders was associated with a lower risk of PTH decrease. In the high cardiovascular (CV) mortality risk subgroup of patients who acquired a low PTH status at 12 months, the main independent factor at 12 months associated with significant 12- to 24-month CV mortality was high dialysate calcium (odds ratio, 5.44; 95% CI, 2.52–11.75). Thus, patients with a serum PTH decrease to low values after 1 year of hemodialysis treatment are at high risk of short-term CV death. High dialysate calcium was an important contributor to PTH oversuppression, and continued use was associated with increased CV mortality