Study of the behavior of biodegradable starch/polyvinyl alcohol/rosin blends

Biodegradable potato starch/PVA samples containing different concentrations of rosin were prepared by melt-mixing in order to study the enhancement of the properties of native starch films. Glycerol and polyvinyl alcohol (PVA) are commonly used as plasticizers of starch. Their relatively low molecular weight (compared with starch) contributes to a good processability. Rosin is a renewable product whose incorporation in the starch/PVA matrix induces processing aid and reinforcing effects. Its relatively high molecular weight might prevent its migration to the surface of the final product. Water content, solubility in water, mechanical properties, microstructure and dynamic mechanical analysis of the samples were studied. The addition of 8% rosin to starch/PVA blends led to tensile strength values higher than 10 MPa and elongation at break values close to 2000%, values comparable to those offered by conventional polymers used in food packaging, for example LDPE. Furthermore, starch compounds have low cost and high biodegradability.This work was partially supported from the European Commission (FEDER/ERDF) and the Spanish MINECO (Ref. CTQ2016-78246-R) and Generalitat Valenciana (Project PROMETEOII/2014/007). M.G. Montalbán acknowledges support from MINECO (Juan de la Cierva-Formación contract, Ref. FJCI-2016-28081)

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Sistemas de protección y detección de contagios en los pediatras de atención primaria en la epidemia por COVID-19

Introducción: durante la pandemia de COVID-19, el uso de equipos y dispositivos de protección por parte de los profesionales es fundamental para evitar la transmisión de la infección en el colectivo de sanitarios. Material y métodos: el Grupo Laboral-Profesional de la Asociación Española de Pediatría de Atención Primaria (AEPap) ha realizado una encuesta a los vocales autonómicos de la AEPap para conocer la disponibilidad que han tenido los pediatras de Atención Primaria (PAP) de sistemas de protección frente a la enfermedad, y las pruebas diagnósticas realizadas para el diagnóstico de los contagios de los PAP. Resultados: en marzo de 2020, solo en el 32% de las comunidades autónomas (CC. AA.), los pediatras tenían sistemas de protección adecuados. En abril ascendió al 70%. En todas las CC. AA. se han registrado casos de PAP enfermos, aunque es difícil cuantificar el número de afectados. De las que tenemos datos, sumando el número de pediatras enfermos conocido, más test de reacción en cadena de la polimerasa (PCR) positivo, los que han estado en aislamiento y los ingresados, la cifra asciende al 7,65% de la cifra total de PAP. Los test rápidos serológicos o PCR o ambos se han realizado en seis comunidades los últimos días de abril y en otras seis los primeros días de mayo. Entre las CC. AA. de las que hay información, Aragón es la única comunidad en la que no se ha realizado test. Se ha correlacionado la disponibilidad de los sistemas de protección y el gasto sanitario. Conclusiones: los sistemas de protección han sido insuficientes. Las CC. AA. con mayor gasto sanitario han contado más precozmente con sistemas de protección adecuados. Han resultado infectados PAP en todas las comunidades autónomas, especialmente en Madrid, Castilla y León y Comunidad Valenciana. La detección de profesionales afectos por la infección ha sido tardía

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Geomorphological features along the shelf of the southern Brazilian margin: Implications for shallow-water sediment transport induced by ocean currents

Chirp profiles collected on the southern Brazilian shelf were combined with sedimentological and hydrodynamic data to characterize shelf geomorphology, focusing on the development of outer shelf bedforms and their genetic links with major oceanic currents. Outer shelf sediment accumulations are interpreted as two scales of bedforms, such as dunes and sand ridges. In the São Paulo Bight, cuspate bedforms are bounded landward by a geomorphological scarp. The sector between Florianopolis and Mostardas also exhibits frequent asymmetric bedforms, whereas the inner- middle shelf is covered by semitransparent sheets. The southern Rio Grande Cone is characterized by stratified deposits covering vast outer shelf areas. Surficial sediment samples reveal a dominantly muddy composition and relatively high carbonate contents. Hydrodynamic data indicate a major influence of the Brazil Current over the São Paulo Bight. The prolific bedform outer-shelf environment is assumed to be mostly relict formed in a transgressive shallow-water setting. The sand ridges are believed to have evolved from a moribund stage characterized by morphological degradation to a relict stage, with preservation enhanced by fine-grained winnowing, coarse sediment armoring, and early cementation. Bedform migration seems to be occurring on the São Paulo Bight due to the presence of a nearly permanent meander of the Brazil Current. Over most of the inner shelf, the northward advection of sediments mainly led by the Brazilian Coastal Current has formed extensive fine-grained deposits. The occurrence of a relict shelf scarp may have conditioned the formation of the outer-shelf bedform environment. The vast spatial distribution of bedforms over most of the outer shelf seems comparable with other shelf areas, such as the south African shelf, dominated by the influence of unidirectional oceanic currents. Dune dimensions are lower on the Brazilian shelf, due to their relict character, the geomorphological configuration of the margin, and the scarcity of sand sources.The authors acknowledge the crew and researchers of R/V Alpha Crucis (University of São Paulo), who participated in Mudbelts I and II cruises. Funding was provided by the São Paulo Science Foundation (FAPESP), grants 2010/06147-5 and 2015/17763-2. F.J. Lobo acknowledges FAPESP for the concession of grant n° 2019/27436-0 as a Visiting Researcher at Instituto Oceanografico, University of São Paulo, from 29 January to 11 March 2023. A. López-Quirós thanks funding provided by FJC2021-047046-I (MCIN/AEI/10.13039/501100011033 and NextGenerationEU/PRTR). M.M. de Mahiques acknowledges the Brazilian Council for Scientific and Technological Development (CNPq) for Research Grant No. 300962/2018-5.Peer reviewe