Mood impact on cardiovascular reactivity when task difficulty is unclear

Research in the context of the mood-behavior-model (Gendolla in Rev Gen Psychol 4:348-408, 2000) has shown that moods can have an impact on effort mobilization due to congruency effects on demand appraisals. However, the mood research literature suggests that mood may also influence effort mobilization by its impact on appraisals of the instrumentality of success. In a single factor (mood valence: negative vs. neutral vs. positive) between-persons design, participants performed a memory task under conditions of unclear task difficulty. By successfully performing the task, participants could earn the chance to win a monetary reward. As predicted for tasks with unclear difficulty, effort mobilization—assessed as cardiovascular reactivity—increased from negative to positive mood. This effect was mediated by the subjective probability of winning the monetary reward for successful performance. These results demonstrate for the first time that mood can influence effort mobilization via the estimated instrumentality of succes

CSR Business as Usual? The Case of the Tobacco Industry

Tobacco companies have started to position themselves as good corporate citizens. The effort towards CSR engagement in the tobacco industry is not only heavily criticized by anti-tobacco NGOs. Some opponents such as the the World Health Organization have even categorically questioned the possibility of social responsibility in the tobacco industry. The paper will demonstrate that the deep distrust towards tobacco companies is linked to the lethal character of their products and the dubious behavior of their representatives in recent decades. As a result, tobacco companies are not in the CSR business in the strict sense. Key aspects of mainstream CSR theory and practice such as corporate philanthropy, stakeholder collaboration, CSR reporting and self-regulation, are demonstrated to be ineffective or even counterproductive in the tobacco industry. Building upon the terminology used in the leadership literature, the paper proposes to differentiate between transactional and transformational CSR arguing that tobacco companies can only operate on a transactional level. As a consequence, corporate responsibility in the tobacco industry is based upon a much thinner approach to CSR and has to be conceptualized with a focus on transactional integrity across the tobacco supply chai

Optimal Exploitation of the Sentinel-2 Spectral Capabilities for Crop Leaf Area Index Mapping

The continuously increasing demand of accurate quantitative high quality information on land surface properties will be faced by a new generation of environmental Earth observation (EO) missions. One current example, associated with a high potential to contribute to those demands, is the multi-spectral ESA Sentinel-2 (S2) system. The present study focuses on the evaluation of spectral information content needed for crop leaf area index (LAI) mapping in view of the future sensors. Data from a field campaign were used to determine the optimal spectral sampling from available S2 bands applying inversion of a radiative transfer model (PROSAIL) with look-up table (LUT) and artificial neural network (ANN) approaches. Overall LAI estimation performance of the proposed LUT approach (LUTN₅₀) was comparable in terms of retrieval performances with a tested and approved ANN method. Employing seven- and eight-band combinations, the LUTN₅₀ approach obtained LAI RMSE of 0.53 and normalized LAI RMSE of 0.12, which was comparable to the results of the ANN. However, the LUTN50 method showed a higher robustness and insensitivity to different band settings. Most frequently selected wavebands were located in near infrared and red edge spectral regions. In conclusion, our results emphasize the potential benefits of the Sentinel-2 mission for agricultural applications

European Information System for Organic Markets (EISFOM QLK5-2002-02400): WP 2: “Data collection and processing systems (DCPS) for the conventional markets” and WP 3: “Data collection and processing systems for organic markets” = Deliverable D2

European markets for organic products are developing fast. In Europe, as other parts of the world, more and more farm land is being converted to organic production. In order to adjust production and consumption levels, detailed market information is needed, especially where decisions with a long-term impact need to be taken, for example on converting specific land or livestock enterprises requiring high levels of investment in glasshouses, housing, processing facilities etc. Since public subsidies (regional / national / European) are heavily involved in these investments, valid, accurate and up-to-date information is essential not only for farmers and growers, but also for policy-makers, consultants, processing industry etc. EU-research projects such as OFCAP (FAIR3-CT96-1794) and OMIaRD (QLK5-2000-01124) have shown that regional or national data gathering takes place in many countries, but often only very basic data are reported, such as certified organic holdings, land areas and livestock numbers. Important market data, e.g. the amount of production, consumption, international trade or producer and consumer prices, do not exist in most European countries. In some European countries there are only rough estimates of the levels of production and consumption. There is no standardization and data are seldom comparable. Furthermore, detailed information on specific commodities is missing. Hence, investment decisions are taken under conditions of great uncertainty. Likewise, if politicians want to support organic agriculture, they do not know whether it would be better to support production or consumption or to address problems in the marketing channel. The EU concerted action EISfOM (QLK5-2002-02400) (European Information System for Organic Markets) is attempting to take the first steps in solving these problems. The aim of this concerted action is to build up a framework for reporting valid and reliable data for relevant production and market sectors of the European organic sector in order to meet the needs of policy-makers, farmers, processors, wholesalers and other actors involved in organic markets. In order to reach this aim, this action was split into several workpackages. This report describes the approach and results of workpackages 2 and 3. In this first chapter the objective and general approach of these work packages are described. Chapters 2 and 3 provide an overview of international statistics and data collection systems within the food supply chain at the public and the private level. Chapter 4 describes national statistics and data collection systems within the food supply chain. In Chapter 5, an analysis and appraisal is made of the results with regard to organic data collection and processing systems (DCPSs) and their integration into existing common DCPSs. Chapter 6 draws several general conclusions. Two substantial annexes complete the report, one with the country reports on the situation of data collection and processing in all investigated countries and the other with the first and the second stage questionnaires covering the different data collection levels

Bispecifics, trispecifics, and other novel immune treatments in myeloma.

Despite recent advances in treatment, relapses in multiple myeloma (MM) are inevitable. Off-the-shelf immunotherapeutics represent a promising avenue for research, with various classes of agents under development and several demonstrating deep and durable responses in patients who have exhausted all available therapies. Antibody-drug conjugates (ADCs) seek to improve on naked monoclonal antibodies by delivering a cytotoxic payload directly to tumor cells while largely limiting systemic effects. Belantamab mafodotin, a B-cell maturation antigen (BCMA)-targeted ADC, has shown response rates >30% in a phase 2 trial of highly refractory patients and is being investigated in a variety of settings and combinations. Several other ADCs are in earlier stages of development that target cell surface antigens that are internalized, including BCMA, CD38, CD46, CD56, CD74, and CD138. Bispecifics are designed to bring cytotoxic immune effector cells into proximity with tumor cells, and several agents have shown high response rates in early trials. Current targets include BCMA, CD38, GPRC5d, and FCRH5, and all of these seek to engage T cells through CD3. Bispecifics targeting natural killer (NK) cells through CD16 are still in preclinical development. Trispecific antibodies may represent an advance over bispecifics by providing a T-cell costimulatory signal such as CD28, or alternatively, dual MM antigens to increase specificity of NK or T-cell targeting. This is an area of active preclinical research at this time. Lastly, designed ankyrin repeat proteins, which are small antibody-mimetic proteins with high target-binding affinity, have the potential to block multiple pathways at once and provide stimulatory signals to the immune system

Opportunity cost calculations only determine justified effort-Or, What happened to the resource conservation principle?

We welcome the development of a new model on effort and performance and the critique on existing resource-based models. However, considering the vast evidence for the significant impact of experienced task demand on resource allocation, we conclude that Kurzban et al.'s opportunity cost model is only valid for one performance condition: if task demand is unknown or unspecifie

Multiparty Languages: The Choreographic and Multitier Cases (Pearl)

Choreographic languages aim to express multiparty communication protocols, by providing primitives that make interaction manifest. Multitier languages enable programming computation that spans across several tiers of a distributed system, by supporting primitives that allow computation to change the location of execution. Rooted into different theoretical underpinnings - respectively process calculi and lambda calculus - the two paradigms have been investigated independently by different research communities with little or no contact. As a result, the link between the two paradigms has remained hidden for long. In this paper, we show that choreographic languages and multitier languages are surprisingly similar. We substantiate our claim by isolating the core abstractions that differentiate the two approaches and by providing algorithms that translate one into the other in a straightforward way. We believe that this work paves the way for joint research and cross-fertilisation among the two communities

Halpha rotation curves: the soft core question

We present high resolution Halpha rotation curves of 4 late-type dwarf galaxies and 2 low surface brightness galaxies (LSB) for which accurate HI rotation curves are available from the literature. Observations are carried out at Telescopio Nazionale Galileo (TNG). For LSB F583-1 an innovative dispersing element was used, the Volume Phase Holographic (VPH) with a dispersion of about 0.35 A/pxl. We find good agreement between the Halpha data and the HI observations and conclude that the HI data for these galaxies suffer very little from beam smearing. We show that the optical rotation curves of these dark matter dominated galaxies are best fitted by the Burkert profile. In the centers of galaxies, where the N-body simulations predict cuspy cores and fast rising rotation curves, our data seem to be in better agreement with the presence of soft cores.Comment: Accepted for Publication in ApJ with minor changes require

Mass Determination in SUSY-like Events with Missing Energy

We describe a kinematic method which is capable of determining the overall mass scale in SUSY-like events at a hadron collider with two missing (dark matter) particles. We focus on the kinematic topology in which a pair of identical particles is produced with each decaying to two leptons and an invisible particle (schematically, $pp\to YY+jets$ followed by each $Y$ decaying via $Y\to \ell X\to \ell\ell'N$ where $N$ is invisible). This topology arises in many SUSY processes such as squark and gluino production and decay, not to mention t\anti t di-lepton decays. In the example where the final state leptons are all muons, our errors on the masses of the particles $Y$, $X$ and $N$ in the decay chain range from 4 GeV for 2000 events after cuts to 13 GeV for 400 events after cuts. Errors for mass differences are much smaller. Our ability to determine masses comes from considering all the kinematic information in the event, including the missing momentum, in conjunction with the quadratic constraints that arise from the $Y$, $X$ and $N$ mass-shell conditions. Realistic missing momentum and lepton momenta uncertainties are included in the analysis.Comment: 41 pages, 14 figures, various clarifications and expanded discussion included in revised version that conforms to the version to be publishe

Bispecific Antibodies in Multiple Myeloma: Present and Future.

UNLABELLED: Despite many recent advances in therapy, there is still no plateau in overall survival curves in multiple myeloma. Bispecific antibodies are a novel immunotherapeutic approach designed to bind antigens on malignant plasma cells and cytotoxic immune effector cells. Early-phase clinical trials targeting B-cell maturation antigen (BCMA), GPRC5D, and FcRH5 have demonstrated a favorable safety profile, with mainly low-grade cytokine release syndrome, cytopenias, and infections. Although dose escalation is ongoing in several studies, early efficacy data show response rates in the most active dose cohorts between 61% and 83% with many deep responses; however, durability remains to be established. Further clinical trial data are eagerly anticipated. SIGNIFICANCE: Overall survival of triple-class refractory multiple myeloma remains poor. Bispecific antibodies are a novel immunotherapeutic modality with a favorable safety profile and impressive preliminary efficacy in heavily treated patients. Although more data are needed, bispecifics will likely become an integral part of the multiple myeloma treatment paradigm in the near future. Studies in earlier lines of therapy and in combination with other active anti-multiple myeloma agents will help further define the role of bispecifics in multiple myeloma