Reasoning About a Service-oriented Programming Paradigm

This paper is about a new way for programming distributed applications: the service-oriented one. It is a concept paper based upon our experience in developing a theory and a language for programming services. Both the theoretical formalization and the language interpreter showed us the evidence that a new programming paradigm exists. In this paper we illustrate the basic features it is characterized by

Low-latency analysis pipeline for compact binary coalescences in the advanced gravitational wave detector era

The multi-band template analysis (MBTA) pipeline is a low-latency coincident analysis pipeline for the detection of gravitational waves (GWs) from compact binary coalescences. MBTA runs with a low computational cost, and can identify candidate GW events online with a sub-minute latency. The low computational running cost of MBTA also makes it useful for data quality studies. Events detected by MBTA online can be used to alert astronomical partners for electromagnetic follow-up. We outline the current status of MBTA and give details of recent pipeline upgrades and validation tests that were performed in preparation for the first advanced detector observing period. The MBTA pipeline is ready for the outset of the advanced detector era and the exciting prospects it will bring.Comment: 18 pages, 10 figure

Principali tecniche e strumenti per il rilievo tridimensionale in ambito archeologico

The increase of 3D acquisition and modeling techniques applied to archeology is due principally to (i) their capacity to survey archeological artifacts with high precision and a non-contact approach and (ii) the possibility to create 3D digital models useful for data analysis, simulation and preservation. These benefits in terms of knowledge oblige the contemporary archaeologist to acquire a better understanding of 3D acquisition and modeling principles and practice. This evidence arises from the necessity of adopting a common language for experts in 3D data management and archaeologists with the principal aim being the understanding of each other’s requirements and sharing of the purposes of the project. In this article the authors propose a concise but exhaustive explanation of the working principles of active and passive 3D acquisition techniques. For each one a description of instruments and methodologies is developed, pointing out pros and cons of every technique. In conclusion, a sensor fusion approach is presented as an interesting solution to increase the instrument performances while obtaining at the same time a quality improvement of 3D acquisition and modeling results. A final multi-resolution application about Pompeii Forum 3D modeling follows and closes the article

Principali tecniche e strumenti per il rilievo tridimensionale in ambito archeologico

The increase of 3D acquisition and modeling techniques applied to archeology is due principally to (i) their capacity to survey archeological artifacts with high precision and a non-contact approach and (ii) the possibility to create 3D digital models useful for data analysis, simulation and preservation. These benefits in terms of knowledge oblige the contemporary archaeologist to acquire a better understanding of 3D acquisition and modeling principles and practice. This evidence arises from the necessity of adopting a common language for experts in 3D data management and archaeologists with the principal aim being the understanding of each other’s requirements and sharing of the purposes of the project. In this article the authors propose a concise but exhaustive explanation of the working principles of active and passive 3D acquisition techniques. For each one a description of instruments and methodologies is developed, pointing out pros and cons of every technique. In conclusion, a sensor fusion approach is presented as an interesting solution to increase the instrument performances while obtaining at the same time a quality improvement of 3D acquisition and modeling results. A final multi-resolution application about Pompeii Forum 3D modeling follows and closes the article

Blockchain-based access control management for Decentralized Online Social Networks

Online Social Networks (OSNs) represent today a big communication channel where users spend a lot of time to share personal data. Unfortunately, the big popularity of OSNs can be compared with their big privacy issues. Indeed, several recent scandals have demonstrated their vulnerability. Decentralized Online Social Networks (DOSNs) have been proposed as an alternative solution to the current centralized OSNs. DOSNs do not have a service provider that acts as central authority and users have more control over their information. Several DOSNs have been proposed during the last years. However, the decentralization of the social services requires efficient distributed solutions for protecting the privacy of users. During the last years the blockchain technology has been applied to Social Networks in order to overcome the privacy issues and to offer a real solution to the privacy issues in a decentralized system. However, in these platforms the blockchain is usually used as a storage, and content is public. In this paper, we propose a manageable and auditable access control framework for DOSNs using blockchain technology for the definition of privacy policies. The resource owner uses the public key of the subject to define auditable access control policies using Access Control List (ACL), while the private key associated with the subject's Ethereum account is used to decrypt the private data once access permission is validated on the blockchain. We provide an evaluation of our approach by exploiting the Rinkeby Ethereum testnet to deploy the smart contracts. Experimental results clearly show that our proposed ACL-based access control outperforms the Attribute-based access control (ABAC) in terms of gas cost. Indeed, a simple ABAC evaluation function requires 280,000 gas, instead our scheme requires 61,648 gas to evaluate ACL rules

R&D and productivity in OECD firms and industries: A hierarchical meta-regression analysis

The relationship between R&D investment and firm/industry productivity has been investigated widely following seminal contributions by Zvi Griliches and others from late 1970s onwards. We aim to provide a systematic synthesis of the evidence, using 1253 estimates from 65 primary studies that adopt the so-called primal approach. In line with prior reviews, we report that the average elasticity and rate-of-return estimates are positive. In contrast to prior reviews, however, we report that: (i) the estimates are smaller and more heterogeneous than what has been reported before; (ii) residual heterogeneity remains high among firm-level estimates even after controlling for moderating factors; (iii) firm-level rates of return and within-industry social returns to R&D are small and do not differ significantly despite theoretical predictions of higher social returns; and (iv) the informational content of both elasticity and rate-of-return estimates needs to be interpreted cautiously. We conclude by highlighting the implications of these findings for future research and evidence-based policy

New Data on Reproductive System and Spermatozoa Confirm Macrodasys as a Model in Comparative Reproductive Analysis in Macrodasyida (Gastrotricha)

Gastrotricha Macrodasyida, aquatic worms, are primarily hermaphrodites with internal cross-fertilization and indirect sperm transfer. Insightful information on this matter dates to 1978 and derives from an illuminating work focused on two Macrodasys species. The role as a “model” of this taxon clashes, however, with the relative paucity of data concerning the ultrastructure of the accessory organs involved in the sperm transfer. Therefore, we have undertaken a new study on three additional species of Macrodasys focusing on the frontal and caudal organs and also on the spermatozoa. Our observations confirmed the structural plan of the reproductive system reported for the genus, but found some differences concerning the accessory reproductive organs. Most importantly, we found spermatozoa inside the caudal organ of several single specimens, suggestive of a more plausible hypothesis about sperm transfer modality in Macrodasys. In the spermatozoa, the position of the mitochondrion outside rather than inside the nucleus has been confirmed as a major difference between the spermatozoa of Macrodasys species and those of the other Macrodasyida. We suggest that the peculiar structure of the mature spermatozoon of Macrodasys could derive from an incomplete process of spermatogenesis and hence it would be useful to infer phylogenetic alliances

Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort.

BACKGROUND: High interindividual variability in plasma concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone, may lead to suboptimal drug concentration. OBJECTIVE: Using a population pharmacokinetic approach, we aimed to characterize the genetic and non-genetic sources of variability affecting risperidone and 9-hydroxyrisperidone pharmacokinetics, and relate them to common side effects. METHODS: Overall, 150 psychiatric patients (178 observations) treated with risperidone were genotyped for common polymorphisms in NR1/2, POR, PPARα, ABCB1, CYP2D6 and CYP3A genes. Plasma risperidone and 9-hydroxyrisperidone were measured, and clinical data and common clinical chemistry parameters were collected. Drug and metabolite concentrations were analyzed using non-linear mixed effect modeling (NONMEM(®)). Correlations between trough concentrations of the active moiety (risperidone plus 9-hydroxyrisperidone) and common side effects were assessed using logistic regression and linear mixed modeling. RESULTS: The cytochrome P450 (CYP) 2D6 phenotype explained 52% of interindividual variability in risperidone pharmacokinetics. The area under the concentration-time curve (AUC) of the active moiety was found to be 28% higher in CYP2D6 poor metabolizers compared with intermediate, extensive and ultrarapid metabolizers. No other genetic markers were found to significantly affect risperidone concentrations. 9-hydroxyrisperidone elimination was decreased by 26% with doubling of age. A correlation between trough predicted concentration of the active moiety and neurologic symptoms was found (p = 0.03), suggesting that a concentration >40 ng/mL should be targeted only in cases of insufficient, or absence of, response. CONCLUSIONS: Genetic polymorphisms of CYP2D6 play an important role in risperidone, 9-hydroxyrisperidone and active moiety plasma concentration variability, which were associated with common side effects. These results highlight the importance of a personalized dosage adjustment during risperidone treatment

Risks and critical issues related to the discovery on the market of unauthorized live alien species on the Italian territory: Chinese crab (Eriocheir sinensis)

Eriocheir sinensis, Chinese Crab or Chinese Mitten Crab is a catadromous species belonging to the Varunidae family, native to river and estuarine areas of North and South East China and Korea. At European level, E. sinensis is widespread in the main water basins of Central and Northern Europe and, since 2016, it has been included in the list of invasive species important for the European Union and subjected to confinement and eradication measures which include the prohibition of collection, transit and placing on the market of live specimens (Regulation (EC) N° 1143/2014). The Chinese Crab can represent a significant danger for the local ecosystem and for the native biota as well as contributing to the appearance of hydrogeological instability phenomena resulting from the intense excavation and erosion of the riverbanks. The first finding of 5 kg of live specimens of Eriocheir sinensis was recorded in the official control by the UFS (Functional Simple Unit) veterinary public health and food safety of the ASL Toscana Centro at an ethnic catering establishment. The specimens were subjected to seizure, photographed, identified morphologically, and subjected to euthanasia and destruction in accordance with the European requirements for welfare and management of animal by-products. From the sanitary point of view, the dangers associated with the consumption of this crab are mainly biological and chemical therefore, risk communication is fundamental, not only at the level of the competent authorities in the sector, but also for the food business operators

Beam Focusing for Near-Field Multiuser MIMO Communications

Large antenna arrays and high-frequency bands are two key features of future wireless communication systems. The combination of large-scale antennas with high transmission frequencies often results in the communicating devices operating in the near-field (Fresnel) region. In this paper, we study the potential of beam focusing, feasible in near-field operation, in facilitating high-rate multi-user downlink multiple-input multiple-output (MIMO) systems. As the ability to achieve beam focusing is dictated by the transmit antenna, we study near-field signalling considering different antenna structures, including fully-digital architectures, hybrid phase shifter-based precoders, and the emerging dynamic metasurface antenna (DMA) architecture for massive MIMO arrays. We first provide a mathematical model to characterize near-field wireless channels as well as the transmission pattern for the considered antenna architectures. Then, we formulate the beam focusing problem for the goal of maximizing the achievable sum-rate in multi-user networks. We propose efficient solutions based on the sum-rate maximization task for fully-digital, (phase shifters based-) hybrid and DMA architectures. Simulation results show the feasibility of the proposed beam focusing scheme for both single- and multi-user scenarios. In particular, the designed focused beams provide a new degree of freedom to mitigate interference in both angle and distance domains, which is not achievable using conventional far-field beam steering, allowing reliable communications for uses even residing at the same angular direction